Results: 176

Diferentes concentrações de sódio nos fluidos têm impacto variável no dano cerebral, pulmonar e renal no acidente vascular encefálico isquêmico experimental
Different sodium concentrations in fluids have variable impact on brain, lung and kidney damage in experimental ischemic stroke

Introdução: A administração de fluidos é muitas vezes realizada no Acidente Vascular Encefálico isquêmico (AVEi) agudo. Permanecem controvérsias em relação ao efeito de diferentes concentrações de sódio em fluidos administrados após AVEi, bem como seu impacto em órgãos a distância. Nosso...

Adult human neural cells in culture following traumatic brain injury

Rev. Ciênc. Saúde; 13 (3), 2023
Objective: The present study aims to evaluate the viability of adult human neural cells in culture obtained from traumatized brain tissues collected in emergency surgery procedures. Methods: Exploratory, descriptive, quantitative and cross-sectional study evaluating samples obtained from patients who und...

Multidimensional Frailty and Traumatic Brain Injury among Older Adults: A Literature Review

Invest. educ. enferm; 41 (2), 2023
Background. Numerous health conditions in the older adult population can be attributed to falls, including traumatic brain injury (TBI), which can lead to devastating short and long-term sequelae. Older adults are also more likely to experience frailty, which encompasses physical, p...

Astragaloside IV alleviates stroke-triggered early brain injury by modulating neuroinflammation and ferroptosis via the Nrf2/HO-1 signaling pathway

Acta cir. bras; 38 (), 2023
Purpose: Stroke is an acute cerebrovascular disease. Astragaloside IV (AS-IV) is an active ingredient extracted from Astragalus membranaceus with an established therapeutic effect on central nervous system diseases. This study examined the neuroprotective properties and possible mechanisms of AS-IV in st...

Alterações de linguagem em pacientes pós lesão encefálica adquirida na fase aguda
Language changes in patients after brain injury acquired in the acute phase

Caracterizar as alterações de linguagem encontradas em pacientes com lesão encefálica adquirida em fase aguda Métodos: Trata-se de uma pesquisa observacional, descritiva do tipo transversal. A avaliação foi realizada nas enfermarias de um hospital de urgências, com pacientes de idade superior a 1...

Fasudil mediates neuroprotection in ischemia/reperfusion by modulating the ROCK-PPARα-NOX axis

Acta cir. bras; 38 (), 2023
Purpose: Cerebral ischemia-reperfusion (I/R) is a neurovascular disorder that leads to brain injury. In mice, Fasudil improves nerve injury induced by I/R. However, it is unclear if this is mediated by increased peroxisome proliferator-activated receptor-α (PPARα) expression and reduced oxidative damag...

Hiperactividad simpática paroxística en el paciente neurocrítico. Un reto diagnóstico y terapéutico

Rev. chil. anest; 52 (1), 2023
Paroxysmal sympathetic hyperactivity is one of the main causes of neural damage after brain injury. This condition has been mainly described after traumatic brain injury, with poor results in the clinical outcomes. The unifying name “paroxismal sympathetic hyperactivity” and the diagnostic criteria w...

Ulinastatin alleviates early brain injury after traumatic brain injury by inhibiting oxidative stress and apoptosis

Acta cir. bras; 37 (1), 2022
Purpose: Traumatic brain injury (TBI) remains a major public health problem and cause of death. Ulinastatin (UTI), a serine protease inhibitor, has been reported to have an anti-inflammatory effect and play a role in immunoregulation and organ protection by reducing reactive oxygen species (ROS) producti...

Ulinastatin alleviates early brain injury after intracerebral hemorrhage by inhibiting oxidative stress and neuroinflammation via ROS/MAPK/Nrf2 signaling pathway

Acta cir. bras; 37 (6), 2022
Purpose: Spontaneous intracerebral hemorrhage (ICH) is still a major public health problem, with high mortality and disability. Ulinastatin (UTI) was purified from human urine and has been reported to be anti-inflammatory, organ protective, and antioxidative stress. However, the neuroprotection of UTI in...