SUMMARY: The response of the immune system to harmful stimuli leads to inflammation, and the adverse effects of the toxic hepatitis chemical, thioacetamide (TAA) on the human body are well documented. This article investigated the degree of protection provided by the combined pleotropic drug, metformin (...
Metformina/farmacología,
Resveratrol/farmacología,
Tioacetamida/toxicidad,
Cirrosis Hepática/inducido químicamente,
Serina-Treonina Quinasas TOR,
Inflamación,
Factor de Necrosis Tumoral alfa,
Citocinas/antagonistas & inhibidores,
Sirolimus,
Inmunohistoquímica,
Hígado/efectos de los fármacos,
Inhibidor Tisular de Metaloproteinasa-1,
Cirrosis Hepática/tratamiento farmacológico
El síndrome metabólico se define como un trastorno heterogéneo y multifactorial con riesgo cardiovascular elevado. Actualmente se encuentra en franco crecimiento debido al sedentarismo y la ingesta rica en grasas y azúcares. Su tratamiento incluye la indicación de cambios...
Abstract The present study aims to evaluate the effects of Ginkgo biloba (GKB) extract as “add- on” therapy with metformin on the lipid profile, inflammatory markers, leptin and the total antioxidant capacity (TAOC) of patients with type 2 diabetes mellitus (T2DM). It is a multi- center, randomized, ...
BACKGROUND Metformin (MET) is a hypoglycemic drug used for the treatment of diabetes, despite interference in host immunity against microorganisms. Cutaneous infection caused by pathogens such as Leishmania braziliensis (Lb), the agent responsible for cutaneous leishmaniasis (CL) in Brazil, represents a...
SUMMARY OBJECTIVE In view of the high incidence of polycystic ovary syndrome (PCOS) and the unsatisfactory therapeutic effects of dimethyldiguanide or clomifene citrate alone, our study aimed to investigate the therapeutic effects of dimethyldiguanide combined with clomifene citrate in the treatment of...
Moco del Cuello Uterino/efectos de los fármacos,
Clomifeno/farmacología,
Clomifeno/uso terapéutico,
Quimioterapia Combinada,
Endometrio/fisiopatología,
Fármacos para la Fertilidad Femenina/farmacología,
Fármacos para la Fertilidad Femenina/uso terapéutico,
Regulación de la Expresión Génica/efectos de los fármacos,
Hipoglucemiantes/farmacología,
Hipoglucemiantes/uso terapéutico,
Metformina/farmacología,
Metformina/uso terapéutico,
Folículo Ovárico/efectos de los fármacos,
Inducción de la Ovulación,
Síndrome del Ovario Poliquístico/tratamiento farmacológico,
Proteína 1 de Unión a los Elementos Reguladores de Esteroles/efectos adversos,
Proteína 1 de Unión a los Elementos Reguladores de Esteroles/genética
ABSTRACT Aim: The aim of the study is to evaluate the effect of linagliptin versus metformin on insulin secretion, insulin sensitivity and glucose control in patients with impaired glucose tolerance (IGT). Patients and methods: A randomized, double-blind, clinical trial with parallel groups was per-for...
AIMS: To evaluate oxidative stress parameters in patients with type 2 diabetes mellitus treated with metformin, relating these values to its side effects, plasma levels, glycemic control, diabetic complications, lipid profile, and the influence of pharmacotherapeutic follow-up.
METHODS: Patients with typ...
ABSTRACT PURPOSE: To investigate the protective effect of metformin on testicular ischemia/reperfusion (I/R) injury in rats. METHODS: Eighteen adult male Wistar rats were randomly divided into three experimental groups (n=6), as follows: Sham, I/R, and Metformin. 1-hour ischemia was induced by the left...
Metformina/farmacología,
Sustancias Protectoras/farmacología,
Daño por Reperfusión/prevención & control,
Testículo/irrigación sanguínea,
Malondialdehído/metabolismo,
Modelos Animales,
Estrés Oxidativo/efectos de los fármacos,
Peroxidasa/metabolismo,
Distribución Aleatoria,
Ratas Wistar,
Daño por Reperfusión/metabolismo,
Superóxido Dismutasa/metabolismo,
Testículo/metabolismo
Metformin, an oral biguanide approved for the treatment of type II diabetes is widely prescribed for other clinical conditions. Currently, metformin is being investigated as potential anti-tumor agent. However, there have been recent concerns about hepatotoxicity associated with the use of metformin. Thi...
