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Retrospective evaluation and prediction of clearance and toxicity of high dose methotrexate in childhood acute lymphoblastic leukemia patients

Shan, Yuxia; Gao, Hui; Li, Zhong; Li, Jinghua; Liu, Yang; Li, Lujuan; Zhang, Qi.
Braz. J. Pharm. Sci. (Online); 56 (), 2020
To find the predictors of High Dose Methotrexate toxicities in childhood Acute Lymphoblastic Leukemia Patients. This study included 198 Childhood Acute Lymphoblastic Leukemia patients (303 infusions) who were treated with High Dose Methotrexate. Methotrexate levels at different time point were measured b...
Predicción, Metotrexato/administración & dosificación, Metotrexato/análisis, Pacientes/clasificación, Leucemia-Linfoma Linfoblástico de Células Precursoras/patología, Técnica de Inmunoensayo de Enzimas Multiplicadas/instrumentación, Dosificación/efectos adversos, Curva ROC
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Protective effects of silymarin on methotrexate-induced damages in rat testes

Yaman, Turan; Uyar, Ahmet; Kaya, Mehmet Salih; Keles, Ömer Faruk; Uslu, Baris Atalay; Yener, Zabit.
Braz. J. Pharm. Sci. (Online); 54 (1), 2018
Abstract The present study aimed to investigate the protective effects of silymarin (SMN), an antioxidant, on methotrexate (MTX)-induced damage in rat testes. Thirty-two Wistar albino rats were divided into four groups (n = 8): control, MTX (20 mg/kg, i.p. on days 1 and 5), SMN (200 mg/kg, orally), and M...
Silimarina/efectos adversos, Metotrexato/análisis, Testículo/anomalías, Sustancias Protectoras/análisis
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Estudo comparativo do mecanismo de açäo e dos efeitos farmacológicos do Tenoxicam, Indometacina, Dexametasona e Metotrexato no processo inflamatório agudo e crônico

Schutz, Antônio Belträo.
Aprofundamos o estudo dos efeitos farmacológicos da dexametasona, indometacina e tenoxicam e de uma droga citostática (metotrexano), assim como a análise dos mecanismos envolvidos na estimulaçäo flogógena causada por agentes de intensidades fraca, média e forte. Para isso, empregamos o teste edemo...
Antiinflamatorios/análisis, Antiinflamatorios no Esteroideos/análisis, Dexametasona/análisis, Dexametasona/farmacología, Dexametasona/efectos adversos, Indometacina/análisis, Indometacina/efectos adversos, Indometacina/farmacología, Metotrexato/análisis, Metotrexato/efectos adversos, Metotrexato/farmacología, Patología Bucal