Results: 9

Efectos adversos inmunomediados por inhibidores de PD-1
PD-1 inhibitors immune-mediated side effects

Los anticuerpos monoclonales que inhiben los puntos de control PD-1 y CTLA-4 se usan actualmente en el tratamiento del melanoma y cáncer metastásico de pulmón de células no pequeñas, entre otros. Se refiere el caso de una paciente con cáncer de pulmón en tratamiento con pembrolizumab. La paciente ...

Fulvestrant-induced toxic epidermal necrolysis

An. bras. dermatol; 94 (2), 2019
Abstract Toxic epidermal necrolysis is a condition with massive keratinocyte apoptosis, and it is associated with high mortality rates. Fulvestrant, an estrogen receptor antagonist, is indicated in the treatment of estrogen receptor-positive metastatic breast cancer in postmenopausal women. To our knowle...

Primary infratentorial diffuse large b-cell lymphoma: a challenging diagnosis in an immunocompetent patient

SUMMARY We describe the case of a female patient, 52 years old, with dizziness and left motor incoordination for 2 weeks. Brain MRI magnetic resonance imaging) revealed a hyperintense lesion on T2-weighted images, without restricted diffusion, in the left middle cerebellar peduncle. Spectroscopy demonstr...

Actualización del manejo de metástasis encefálicas
Metastasis management update encephalic

Brain metastases represent a critical stage of oncological disease and its frequency is increasing over the recent years. The treatment of brain metastases has moved from a conservative approach to an active management that should be individualized for each patient: in case of single brain metastasis, su...

Bevacizumab and gefitinib enhanced whole-brain radiation therapy for brain metastases due to non-small-cell lung cancer

Braz. j. med. biol. res; 51 (1), 2018
Non-small-cell lung cancer (NSCLC) patients who experience brain metastases are usually associated with poor prognostic outcomes. This retrospective study proposed to assess whether bevacizumab or gefitinib can be used to improve the effectiveness of whole brain radiotherapy (WBRT) in managing patients w...

Tumores da fossa posterior na infância

O autor relata 44 casos de tumores da fossa posterior na infância que säo analisados retrospectivamente com um período médio de seguimento de 4 anos onde procuram abordar os principais síndromes clínicos, a evoluçäo dos meios diagnósticos, principalmente após a intoduçäo da tomografia axial c...