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Tumor suppressive function of Matrin 3 in the basal-like breast cancer

Yang, Jaehyuk; Lee, Seung Jun; Kwon, Yongseok; Ma, Li; Kim, Jongchan.
Biol. Res; 53 (), 2020
BACKGROUND: Basal-like breast cancer (BLBC) or triple-negative breast cancer (TNBC) is an aggressive and highly metastatic subtype of human breast cancer. The present study aimed to elucidate the potential tumor-suppressive function of MATR3, an abundant nuclear protein, in BLBC/TNBC, whose cancer-releva...
Proteínas Asociadas a Matriz Nuclear/genética, Proteínas de Unión al ARN/genética, Neoplasias de la Mama Triple Negativas/genética, Genes Supresores de Tumor, Apoptosis, Línea Celular Tumoral, Movimiento Celular, Proliferación Celular, Transición Epitelial-Mesenquimal, Regulación Neoplásica de la Expresión Génica
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Aspectos moleculares envolvidos no surgimento do Tumor Triplo-Negativo de Mama em pacientes portadoras ou não de mutação germinativa em BRCA1

Nakamura, Kivvi Duarte de Mello.
O Câncer de Mama Triplo-Negativo (CMTN), caracterizado pela perda de expressão dos receptores de estrógeno (RE), de progesterona (RP) e pela não super-expressão/amplificação do receptor do fator de crescimento epidermal humano do tipo 2 (HER-2), é considerado um subtipo bastante agressivo e heter...
Neoplasias de la Mama Triple Negativas/genética, Mutación de Línea Germinal, Genes BRCA1, Análisis de Secuencia de ARN, Neoplasias de la Mama, Secuenciación de Nucleótidos de Alto Rendimiento
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miR-29b-3p promotes progression of MDA-mB-231 triple-negative breast cancer cells through downregulating TRAF3

Zhang, Bao; Shetti, Dattatrya; Fan, Conghui; Wei, Kun.
Biol. Res; 52 (), 2019
BACKGROUND: Breast cancer is the second common malignant cancer among females worldwide. Accumulating studies have indicated that deregulation of miRNA expression in breast cancer will contribute to tumorigenesis and form different cancer subtypes. However, the reported studies on miR-29b-3p-regulated br...
Apoptosis/efectos de los fármacos, Regulación hacia Abajo/genética, MicroARNs/metabolismo, Factor 3 Asociado a Receptor de TNF/metabolismo, Neoplasias de la Mama Triple Negativas/genética, Luciferasas/metabolismo, Factor 3 Asociado a Receptor de TNF/genética, Neoplasias de la Mama Triple Negativas/patología, Western Blotting, Línea Celular Tumoral, Proliferación Celular
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