Results: 6

Interplay of TGFβ signaling and microRNA in thyroid cell loss of differentiation and cancer progression

Fuziwara, Cesar Seigi; Saito, Kelly Cristina; Kimura, Edna Teruko.

Arch. endocrinol. metab. (Online); 63 (5), 2019

ABSTRACT Thyroid cancer has been rapidly increasing in prevalence among humans in last 2 decades and is the most prevalent endocrine malignancy. Overall, thyroid-cancer patients have good rates of long-term survival, but a small percentage present poor outcome. Thyroid cancer aggressiveness is essentiall...

Transformación Celular Neoplásica, Progresión de la Enfermedad, MicroARNs/metabolismo, Invasividad Neoplásica, Metástasis de la Neoplasia, Transducción de Señal, Glándula Tiroides/patología, Neoplasias de la Tiroides/metabolismo, Neoplasias de la Tiroides/patología, Factor de Crecimiento Transformador beta/metabolismo

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Diagnostic utility of DREAM gene mRNA levels in thyroid tumours

Batista, Fernando A; Marcello, Marjory A; Martins, Mariana B; Peres, Karina C; Cardoso, Ulieme O; Silva, Aline C D N; Bufalo, Natassia E; Soares, Fernando A; Silva, Márcio J da; Assumpção, Lígia V; Ward, Laura S.

Arch. endocrinol. metab. (Online); 62 (2), 2018

ABSTRACT Objective The transcriptional repressor DREAM is involved in thyroid-specific gene expression, thyroid enlargement and nodular development, but its clinical utility is still uncertain. In this study we aimed to investigate whether DREAM mRNA levels differ in different thyroid tumors and how thi...

Biomarcadores de Tumor/genética, Biomarcadores de Tumor/metabolismo, Proteínas de Interacción con los Canales Kv/genética, Proteínas de Interacción con los Canales Kv/metabolismo, Estadificación de Neoplasias, Pronóstico, ARN Mensajero/genética, ARN Mensajero/metabolismo, Reacción en Cadena en Tiempo Real de la Polimerasa, Elementos Reguladores de la Transcripción/genética, Proteínas Represoras/genética, Proteínas Represoras/metabolismo, Sensibilidad y Especificidad, Neoplasias de la Tiroides/diagnóstico, Neoplasias de la Tiroides/genética, Neoplasias de la Tiroides/metabolismo

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NMR-based metabolomics to select a surgical method for treating papillary thyroid carcinoma

Wang, Bo; Zhang, Li-Yong; Wang, Si-Si; Yang, Ying-Hong; Zhao, Wen-Xin.

Clinics; 73 (), 2018

OBJECTIVE: This study aims to investigate differences in the metabolomic profiles of patients who received different surgeries for papillary thyroid carcinoma (PTC). METHODS: Two surgical methods, i.e., unilateral and total thyroidectomy, were employed according to different disease conditions. Sera fro...

Espectroscopía de Resonancia Magnética, Metabolómica/métodos, Análisis de Componente Principal, Cáncer Papilar Tiroideo/diagnóstico por imagen, Cáncer Papilar Tiroideo/metabolismo, Cáncer Papilar Tiroideo/cirugía, Neoplasias de la Tiroides/diagnóstico por imagen, Neoplasias de la Tiroides/metabolismo, Neoplasias de la Tiroides/cirugía, Tiroidectomía/métodos

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Medullary thyroid carcinoma - Adverse events during systemic treatment: risk-benefit ratio

Maciel, Léa Maria Zanini; Magalhães, Patrícia Künzle Ribeiro.

Arch. endocrinol. metab. (Online); 61 (4), 2017

ABSTRACT Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor originating from parafollicular C cells of the thyroid and associated with mutations in the proto-oncogene REarranged during Transfection (RET). The prognosis of MTC depends on clinical stage, with a 95.6% 10-year survival rate amo...

Anilidas/efectos adversos, Anilidas/uso terapéutico, Carcinoma Neuroendocrino/tratamiento farmacológico, Carcinoma Neuroendocrino/metabolismo, Piperidinas/efectos adversos, Piperidinas/uso terapéutico, Inhibidores de Proteínas Quinasas/efectos adversos, Inhibidores de Proteínas Quinasas/uso terapéutico, Piridinas/efectos adversos, Piridinas/uso terapéutico, Quinazolinas/efectos adversos, Quinazolinas/uso terapéutico, Medición de Riesgo, Neoplasias de la Tiroides/tratamiento farmacológico, Neoplasias de la Tiroides/metabolismo

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Iodine-131 treatment of thyroid cancer cells leads to suppression of cell proliferation followed by induction of cell apoptosis and cell cycle arrest by regulation of B-cell translocation gene 2-mediated JNK/NF-kappaB pathways

Zhao, L M; Pang, A X.

Braz. j. med. biol. res; 50 (1), 2017

Iodine-131 (131I) is widely used for the treatment of thyroid-related diseases. This study aimed to investigate the expression of p53 and BTG2 genes following 131I therapy in thyroid cancer cell line SW579 and the possible underlying mechanism. SW579 human thyroid squamous carcinoma cells were cultured a...

Apoptosis/efectos de los fármacos, Línea Celular Tumoral, Proliferación Celular/efectos de los fármacos, Radioisótopos de Yodo/farmacología, Radioisótopos de Yodo/uso terapéutico, Sistema de Señalización de MAP Quinasas, Proteínas de Neoplasias/genética, Proteínas de Neoplasias/metabolismo, Reacción en Cadena de la Polimerasa, Neoplasias de la Tiroides/tratamiento farmacológico, Neoplasias de la Tiroides/metabolismo, Neoplasias de la Tiroides/patología

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Açöes do 17B-estradiol sobre a secreçäo de calcitonina "in vitro"

Action of 17B-estradiol on calcitonin secretion \"in vitro\"

Castro, Marise lazaretti; Raue, Friedhelm; Vieira, José Gilberto H; Grauer, Andreas; Ziegler, Reinhard.

Arq. bras. endocrinol. metab; 38 (1), 1994

Em doses farmacológicas a Calcitonina (CT) é tida como um hormônio poupador de cálcio (Ca) e protetor da massa óssea. Devido a isto, tem sido utilizada como alternativa terapêutica das osteoporose pós-menopáusica, doença de grande prevalência entre as mulheres. O papel da CT no desenvolvimento ...

Calcitonina/22063, Estradiol/farmacología, Carcinoma Medular/metabolismo, Neoplasias de la Tiroides/metabolismo, Células Tumorales Cultivadas, Albúmina Sérica Bovina