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Study of the potential toxicity of adrenaline to neurons, using the SH-SY5Y human cellular model

Costa, Vera Marisa; Capela, João Paulo; Bastos, Maria Lourdes; Remião, Fernando; Varner, Kurt James; Duarte, José Alberto; Carvalho, Félix.
Braz. J. Pharm. Sci. (Online); 59 (), 2023
Abstract Prolonged overexposure to catecholamines causes toxicity, usually credited to continuous adrenoceptor stimulation, autoxidation, and the formation of reactive pro-oxidant species. Non-differentiated SH-SY5Y cells were used to study the possible contribution of oxidative stress in adrenaline (ADR...
Neuronas/clasificación, Toxicidad, Epinefrina/agonistas, Antioxidantes/farmacología, Bromuros/antagonistas & inhibidores, d0024770, Enfermedades del Sistema Nervioso Periférico/clasificación, Estrés Oxidativo/efectos de los fármacos, d0077700, Nervios Periféricos/anomalías, d0119410
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Tourette’s Syndrome cervical dystonia induced occipital neuralgia remedied by peripheral nerve stimulation: A case report

Joseph, Crystal; Parkash, Anishinder; Gallagher, John; Chitneni, Ahish; Kaveeshvar, Hirsh.
Rev. Headache Med. (Online); 14 (4), 2023
BACKGROUND: Dystonia is uncommon in Tourette’s syndrome, and occipital neuralgia secondary to Tourette's dystonia is more rare, affecting quality of life. Occipital peripheral nerve stimulation (PNS) is an excellent alternative by being adjustable and minimally invasive. Our case demonstrates occipital...
d0094070, Síndrome de Tourette/complicaciones, Pacientes/clasificación, Nervios Periféricos/anomalías, d0117880
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The Effect of Anakinra on Acrylamide-induced Peripheral Neuropathy and Neuropathic Pain in Rats

Ersoy, Alevtina; Tanoglu, Ceyda; Yazici, Gulce Naz; Coban, Taha Abdulkadir; Mammadov, Renad; Suleyman, Halis.
Braz. J. Pharm. Sci. (Online); 58 (), 2022
Abstract Acrylamide is a neurotoxic compound. Moreover, anakinra is an interleukin-1 (IL-1) receptor antagonist used in rheumatoid arthritis treatment. This study investigated the effect of anakinra on acrylamide-related neuropathy and neuropathic pain. Acrylamide exposure caused a significant decrease ...
Acrilamida/efectos adversos, Estrés Oxidativo/efectos de los fármacos, Inflamación/clasificación, Artritis Reumatoide/patología, Enfermedades del Sistema Nervioso Periférico/patología, Factor de Necrosis Tumoral alfa/farmacología, Umbral del Dolor/clasificación, d0125840, Nervios Periféricos/anomalías, Proteína Antagonista del Receptor de Interleucina 1/antagonistas & inhibidores
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