In tradition
al Mexican medicine, plants from the
Montanoa
genus, family Asteraceae
(
Montanoa tomentosa
,
Montanoa grandiflora
, and
Montanoa frutescens
) have been used to induce labor
owing to their uterotonic properties like those produced by oxytocin (OXT). However, w
hether infusions ...
Todas las drogas de abuso tienen en común la activación del sistema cerebral del placer. Los análisis imagenológicos han arrojado resultados de cambios estructurales en el cerebro de adictos a la cocaína e imágenes cerebrales en sujetos adictos muestran una disminución de la producción de dopamin...
Abstract Background and objectives The mechanisms by which local anesthetics cause neurotoxicity are very complicated. Apoptosis and autophagy are highly coordinated mechanisms that maintain cellular homeostasis against stress. Studies have shown that autophagy activation serves as a protective mechanis...
Anestésicos Locales/toxicidad,
Apoptosis/efectos de los fármacos,
Autofagia/efectos de los fármacos,
Autofagia/fisiología,
Beclina-1/metabolismo,
Bupivacaína/administración & dosificación,
Bupivacaína/toxicidad,
Caspasa 3/metabolismo,
Etiquetado Corte-Fin in Situ,
Proteínas Asociadas a Microtúbulos/metabolismo,
Neuronas/efectos de los fármacos,
Neuronas/patología,
Síndromes de Neurotoxicidad/prevención & control,
Distribución Aleatoria,
Ratas Sprague-Dawley,
Sirolimus/administración & dosificación,
Médula Espinal/efectos de los fármacos
BACKGROUND: Neuronal apoptosis plays a critical event in the pathogenesis of early brain injury after subarachnoid hemorrhage (SAH). This study investigated the roles of Tauroursodeoxycholic acid (TUDCA) in attenuate neuronal apoptosis and underlying mechanisms after SAH. METHODS: Sprague-Dawley rats wer...
ABSTRACT The neuropeptide orexin-A and its receptors are widely distributed in both hippocampal circuitry and pain transmission pathways. Objective: Involvement of the CA1 orexin 1 receptor (OX1R) on the modulation of orofacial pain and pain-induced changes in hippocampal expression of cyclooxygenase-2 ...
Benzoxazoles/farmacología,
Factor Neurotrófico Derivado del Encéfalo/metabolismo,
Capsaicina,
Ciclooxigenasa 2/metabolismo,
Modelos Animales de Enfermedad,
Dolor Facial/metabolismo,
Hipocampo/efectos de los fármacos,
Hipocampo/metabolismo,
Naftiridinas,
Neuronas/efectos de los fármacos,
Neuronas/metabolismo,
Receptores de Orexina/metabolismo,
Orexinas/farmacología,
Ratas Wistar,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Urea/análogos & derivados,
Urea/farmacología
Pereira Alves, Angela Maria;
de Paula, Anderson Luiz;
Moreira, Cassio Rafael;
Ferrari, Fernanda;
Coelho Leal, Jean Paulo;
Hatoum, Ualid Saleh;
Vieira Silva, Helaine Maruska;
Belato Alves, Eder Paulo;
de Miranda Neto, Marcilio Hubner;
Galvanini, Paulo Alexandre.
The effects of quercetin supplementation in NADH-diaphorase positive (NADH-d) neurons of streptozotocin-induced diabetic rats was carried in this study. Fifteen male rats were divided into three groups: normoglycemic (N), diabetic (D) and diabetic supplemented with quercetin (DQ). Whole mount preparation...
Nicotine is the most important alkaloid compound in tobacco. One of the major effects of nicotine is stimulation of mesocorticolimbic system. Prefrontal cortex plays a pivotal role in personality and mental state. It is considered the main cause of addiction as it is located in mesocorticolimbic dopamine...
In Man, artemether is given at 160mg/kg/bodyweight for three days in the treatment of malarial. This study investigated the effects of corresponding 1.23/mg/kg/bodyweight of artemether for a period of seven days on the trapezoid nuclei and the behavioural functions on day 7 after drug administration in r...
Las investigaciones en el campo del dolor y de la analgesia se están enfocando hacia los eventos celulares y moleculares subyacentes a los mecanismos de dolor crónico. En particular, mucha atención está recibiendo el óxido nítrico (ON), un nuevo tipo de neurotransmisor. El ON es un radical libre ga...
