Background: The bioactive peptides derived from snake venoms of the Viperidae family species have been promising as therapeutic candidates for neuroprotection due to their ability to prevent neuronal cell loss, injury, and death. Therefore, this study aimed to evaluate the cytoprotective effects of a sy...
Opiorphin is a pentapeptide, which could be isolated from human fluids and has a decreasing effect on pain. Aim: Since lichen planus is a chronic mucocutaneous disease, which causes pain or burning feeling in the oral mucosa, this study aimed to compare salivary opiorphin levels of oral lichen planus (OL...
SUMMARY: This study is to investigate the role and mechanism of RGD peptide in laryngeal cancer stem cells (CSCs). Laryngeal cancer CD133+Hep-2 CSCs were sorted by flow cytometry. RGD peptide was co-cultured with sorted laryngeal CSCs. Cell proliferation was detected with CCK-8 assay. The mRNA levels of ...
Oligopéptidos/metabolismo,
Integrina alfaVbeta3/antagonistas & inhibidores,
Neoplasias Laríngeas,
Factor A de Crecimiento Endotelial Vascular/antagonistas & inhibidores,
Proliferación Celular,
Western Blotting,
Citometría de Flujo,
Inmunohistoquímica,
Factor A de Crecimiento Endotelial Vascular/genética,
ARN Mensajero/antagonistas & inhibidores,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Células Madre Neoplásicas,
Neovascularización Patológica,
Cartilla de ADN
Abstract: Cost-effectiveness analysis is essential in health decision making. Several countries use it as synthesis of evidence to incorporate health technologies. The protease inhibitors (PI) boceprevir (BOC) and telaprevir (TVR) are indicated for chronic hepatitis C treatment and were incorporated in g...
Antivirales/economía,
Antivirales/uso terapéutico,
Brasil,
Análisis Costo-Beneficio,
Quimioterapia Combinada,
Genotipo,
Hepacivirus,
Hepatitis C Crónica/tratamiento farmacológico,
Hepatitis C Crónica/economía,
Interferón alfa-2,
Interferón-alfa,
Oligopéptidos,
Polietilenglicoles,
Prolina/análogos & derivados,
Años de Vida Ajustados por Calidad de Vida,
Proteínas Recombinantes,
Ribavirina
ABSTRACT Purpose: 68Ga-PSMA PET/CT imaging is a promising modality for the staging of recurrent prostate cancer (PCa). Current evidence suggests limited diagnostic value of the 68Ga-PSMA PET/CT in PSA-levels ≤0.3ng/mL. Experimental data have demonstrated an increase in PSMA-expression in PCa metas...
Antagonistas de Andrógenos/uso terapéutico,
Glicoproteínas de Membrana,
Persona de Mediana Edad,
Clasificación del Tumor,
Metástasis de la Neoplasia/diagnóstico por imagen,
Recurrencia Local de Neoplasia/patología,
Oligopéptidos/uso terapéutico,
Compuestos Organometálicos,
Tomografía Computarizada por Tomografía de Emisión de Positrones/métodos,
Antígeno Prostático Específico/sangre,
Neoplasias de la Próstata/patología,
Radiofármacos,
Valores de Referencia,
Reproducibilidad de los Resultados,
Factores de Tiempo
Necroptosis is a regulated cell death mechanism. However, it is unknown whether necroptosis is involved in the death of tumor necrosis factor-α (TNF-α)-treated osteoblasts. Therefore, we conducted the study with TNF-α, Nec-1 (a specific inhibitor of necroptosis), and Z-IETD-FMK (a specific...
Caspasa 8/efectos de los fármacos,
Inhibidores de Caspasas/farmacología,
Supervivencia Celular/efectos de los fármacos,
Imidazoles/farmacología,
Indoles/farmacología,
L-Lactato Deshidrogenasa/farmacología,
Necrosis/patología,
Oligopéptidos/farmacología,
Osteoblastos/patología,
Osteoblastos/efectos de los fármacos,
Fosforilación,
Factor de Necrosis Tumoral alfa/farmacología
Turones, L C;
Cruz, K R da;
Camargo-Silva, G;
Reis-Silva, L L;
Graziani, D;
Ferreira, P M;
Galdino, P M;
Pedrino, G R;
Santos, R;
Costa, E A;
Ianzer, D;
Xavier, C H.
The heptapeptide Bj-PRO-7a, isolated and identified from Bothrops jararaca (Bj) venom, produces antihypertensive and other cardiovascular effects that are independent on angiotensin converting enzyme inhibition, possibly relying on cholinergic muscarinic receptors subtype 1 (M1R). However, whether Bj-PRO...
Ansiedad,
Conducta Animal/efectos de los fármacos,
Conducta Animal/fisiología,
Venenos de Crotálidos/química,
Depresión,
Conducta Exploratoria/efectos de los fármacos,
Oligopéptidos/aislamiento & purificación,
Oligopéptidos/farmacología,
Prolina/aislamiento & purificación,
Prolina/farmacología,
Ratas Wistar
Abstract INTRODUCTION: Chronic hepatitis C is a leading cause of liver disease. Infection triggers an immediate immune response in the host that is mediated by humoral/cellular mechanisms. T cells respond to infection via secretion of cytokines, which inhibit or stimulate one another, leading to cytoki...
Antivirales/administración & dosificación,
Citocinas/sangre,
Quimioterapia Combinada,
Citometría de Flujo,
Genotipo,
Hepatitis C Crónica/sangre,
Hepatitis C Crónica/tratamiento farmacológico,
Persona de Mediana Edad,
Oligopéptidos/administración & dosificación,
Prolina/administración & dosificación,
Prolina/análogos & derivados,
Estudios Prospectivos,
Resultado del Tratamiento,
Carga Viral
Mattiolli, Aline B;
Santos, Allan;
Vicente, Andreia;
Queiroz, Marcelo;
Bastos, Diogo;
Herchenhorn, Daniel;
Srougi, Miguel;
Peixoto, Fabio A;
Morikawa, Lisa;
Silva, João Luiz Fernandes da;
Etchebehere, Elba.
ABSTRACT Purpose: The purpose of our study was to evaluate the clinical impact of 68Ga-PSMA PET / CT in the setting of biochemical recurrence of prostate cancer. Materials and Methods: We retrospectively evaluated 125 prostate cancer patients submitted to the 68Ga-PSMA PET / CT due to biochemical recur...
Ácido Edético/análogos & derivados,
Estudios de Seguimiento,
Persona de Mediana Edad,
Clasificación del Tumor,
Recurrencia Local de Neoplasia/diagnóstico por imagen,
Recurrencia Local de Neoplasia/terapia,
Oligopéptidos,
Tomografía Computarizada por Tomografía de Emisión de Positrones/métodos,
Antígeno Prostático Específico/sangre,
Neoplasias de la Próstata/sangre,
Neoplasias de la Próstata/diagnóstico por imagen,
Neoplasias de la Próstata/terapia,
Estudios Retrospectivos,
Sensibilidad y Especificidad
