Abstract Glucose exposure induces toxic effects on the function of the pancreatic islets. Moreover, myricitrin as a flavonoid glycoside may have favorable effects on insulin secretion of Langerhans islets. The present study aimed to investigate the effect of Myricitrin and its solid lipid nanoparticles (...
SUMMARY: This study aimed to investigate the effect of exogenous ghrelin on pancreatic growth and development in African ostrich chicks. Sixteen 40-day-old African ostrich chicks (male or female) were randomly divided into four groups and injected intravenously metatarsal vein with saline (control) or gh...
SUMMARY: Acute pancreatitis is a frequent life-threatening inflammatory disease of the pancreas characterized by severe abdominal pain that lasts for days to weeks. We sought to determine whether the antidiabetic and anti-inflammatory drug, metformin can substantially protect against acute pancreatitis i...
Pancreatitis Aguda Necrotizante/tratamiento farmacológico,
Pancreatitis Aguda Necrotizante/inducido químicamente,
Arginina/toxicidad,
Metformina/administración & dosificación,
Peroxidasa/antagonistas & inhibidores,
Interleucina-10/metabolismo,
Modelos Animales de Enfermedad,
Interleucina-10,
Ratas Wistar,
Páncreas/efectos de los fármacos,
Sustancias Protectoras,
L-Lactato Deshidrogenasa/antagonistas & inhibidores,
Factor de Necrosis Tumoral alfa/antagonistas & inhibidores
Background: The harmful effects of type 2 diabetes mellitus and its complications have become a major global public health problem. In this study, the effects of Momordica charantia saponins (MCS) on lipid metabolism, oxidative stress, and insulin signaling pathway in type 2 diabetic rats were investigat...
Diabetes Mellitus Experimental/tratamiento farmacológico,
Momordica charantia/química,
Saponinas/uso terapéutico,
Saponinas/farmacología,
Ratas Wistar,
Hipoglucemiantes/farmacología,
Hipoglucemiantes/uso terapéutico,
Estrés Oxidativo/efectos de los fármacos,
Resistencia a la Insulina,
Lípidos,
Glucemia/efectos de los fármacos,
Peso Corporal,
Hígado/efectos de los fármacos,
Páncreas/efectos de los fármacos
Antipsychotic Drugs (APDs) are being widely prescribed to treat various disorders, including schizophrenia and bipolar disorder; however, abnormal glucose metabolism and weight gain have been reported with Atypical Anti-Psychotic drugs (AAPDs) that can lead to insulin-resistance and type 2 diabetes melli...
This study was aimed to search the effect of wheatgrass on the Total Antioxidan (TAS)-Oxidan Status (TOS) and DNA damage in rat with diabetes. The rats used in the study were randomly divided into 4 groups that each of has 10 rats: Control group; 1 ml single dose phosphate-citrate buffer injected i.p (pH...
Triticum/química,
Extractos Vegetales/administración & dosificación,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Antioxidantes/análisis,
Estrés Oxidativo/efectos de los fármacos,
Páncreas/efectos de los fármacos,
Ratas Wistar,
Daño del ADN/efectos de los fármacos,
Oxidantes/sangre,
Células Secretoras de Insulina/efectos de los fármacos,
Extractos Vegetales/farmacología,
Glucemia/efectos de los fármacos
Ulomoides dermestoides is a beetle traditionally consumed to treat diabetes. In this study, we performed a composition analysis of U. dermestoides to obtain the principal fractions, which were used to assess the effect on glycemia, liver and pancreatic architecture, and PPARγ and GLUT4 expression. N...
Escarabajos/química,
Diabetes Mellitus Experimental/tratamiento farmacológico,
Diabetes Mellitus Experimental/metabolismo,
Diabetes Mellitus Experimental/patología,
Cuerpo Adiposo/química,
Cromatografía de Gases y Espectrometría de Masas,
Regulación de la Expresión Génica,
Transportador de Glucosa de Tipo 4/efectos de los fármacos,
Transportador de Glucosa de Tipo 4/metabolismo,
Hipoglucemiantes/aislamiento & purificación,
Hipoglucemiantes/uso terapéutico,
Hígado/efectos de los fármacos,
Hígado/metabolismo,
Hígado/patología,
PPAR gamma/efectos de los fármacos,
PPAR gamma/metabolismo,
Páncreas/efectos de los fármacos,
Páncreas/metabolismo,
Páncreas/patología,
ARN Mensajero/efectos de los fármacos,
ARN Mensajero/metabolismo,
Extractos de Tejidos/aislamiento & purificación,
Extractos de Tejidos/uso terapéutico
SUMMARY: Diabetes mellitus is a common metabolic disease. There are many natural agents available to control and treat diabetes. Crab shell extract has antioxidant properties. The aim of present study was to investigate the effect of crab shell hydroalcoholic extract on blood glucose, liver enzymes, nitr...
Prolonged alcohol consumption has consequences on the liver, producing necrotic precipitates and fibrosis, on the pancreas, causing the pancreatic acini to atrophy and destroying insulin-producing cells, and on the central nervous system (CNS), causing the gray and white matter in the frontal lobes of th...
Etanol/toxicidad,
Intoxicación Alcohólica/tratamiento farmacológico,
Sistema Nervioso Central/efectos de los fármacos,
Antioxidantes/uso terapéutico,
Hígado/efectos de los fármacos,
Páncreas/efectos de los fármacos,
Estrés Oxidativo,
Etanol/metabolismo,
Sistema Nervioso Central/patología,
Hígado/patología,
Páncreas/patología
Galunisertib (LY2157299), a selective ATP-mimetic inhibitor of TGF-β receptor I (TGF-βRI), is the only known TGF-β pathway inhibitor. In the present study, we investigated the effect of galunisertib on taurocholate (TAC)-induced acute pancreatitis (AP) in rats, and the role of TGF-β a...
Enfermedad Aguda,
Amilasas/sangre,
Apoptosis,
Western Blotting,
Ensayo de Cambio de Movilidad Electroforética,
Ensayo de Inmunoadsorción Enzimática,
Etiquetado Corte-Fin in Situ,
Interleucina-1beta/sangre,
Interleucina-6/sangre,
Lipasa/sangre,
Páncreas/efectos de los fármacos,
Páncreas/patología,
Pancreatitis/tratamiento farmacológico,
Pancreatitis/patología,
Peroxidasa/análisis,
Inhibidores de Proteínas Quinasas/uso terapéutico,
Proteínas Serina-Treonina Quinasas/antagonistas & inhibidores,
Pirazoles/uso terapéutico,
Quinolinas/uso terapéutico,
Resultado del Tratamiento
