Results: 13

Network pharmacology strategy to investigate the pharmacological effects of Suanzaoren Decoction on insomnia

Abstract Suanzaoren Decoction (SZRD) is an ancient prescription used in the treatment of insomnia. This study aimed to investigate the components and targets of SZRD in treating insomnia. First, the compounds of five herbs in SZRD were collected from the Traditional Chinese Medicine Systems Pharmacology ...

Phytohormone abscisic acid boosts pentobarbital-induced sleep through activation of GABA-A, PPARβ and PPARγ receptor signaling

Arq. neuropsiquiatr; 79 (3), 2021
ABSTRACT Background: Sleep disorders induce anxiety and forgetfulness and change habits. The chemical hypnotic drugs currently used have serious side effects and, therefore, people are drawn towards using natural compounds such as plant-based healing agents. Abscisic acid (ABA) is produced in a variety...

Antinociceptive activity of Thyme (Thymus vulgaris L. ) and interactions with neurotropics and analgesics

The plant world represents an important source of potential therapeutic agents, but concomitant administration of herbal and conventional medications may result in interactions with subsequent beneficial or adverse effects. This study was designed to examine the analgesic effect of thyme tincture and thy...

Mecanismos celulares y moleculares subyacentes de las arritmias cardíacas inducidas por drogas y asociadas con la prolongación del intervalo QT

Drug-induced QT prolongation is sometimes associated with life-threatening torsade de pointes (TdP) arrhythmias that develop as a consequence of the amplification of electrical heterogeneities intrinsic to the ventricular myocardium. These heterogeneities exist because of differences in the time course o...

Evaluation of the effects of photooxidized Echis carinatus venom on learning, memory and stress

Snake venoms are a mixture of complex proteins, which have many physical and pharmacological properties. Photochemical detoxification has been suggested to generate photooxidized Echis carinatus venom product (POECVP). Antigenically-active photooxidized species of Echis carinatus venom could be obtained ...

Efeito agudo da estimulação ventricular multisítio no bloqueio atrioventricular experimental em suínos
An experimental model studied the effect of artificial pacemakers on heart physiological phenomena and its correlation with clinical practice

Os modelos experimentais permitem o estudo da atuação do marcapasso artificial em fenômenos fisiológicos do coração e sua correlação com a prática clínica. Os objetivos deste trabalho foram padronizar a técnica de obtençao de Bloqueio atrioventricular Total (BAVT)experimental, o estudo do Dé...

Utilizaçäo da máscara laríngea no cäo: aspectos hemodinâmicos, respiratórios e de microscopia óptica e eletrônica

Introduçäo e Objetivos: A utilizaçäo da cânula de intubaçäo endotraqueal em pacientes sob anestesia é eficaz na manutençäo da permeabilidade das vias áreas, mas näo é isenta de morbidade. Recentemente, foi introduzida, no homem, a máscara laríngea (ML), para manutençäo da permeabilidade ...

El epidurograma: un método de verificación del espacio epidural en un modelo animal
The epidurogram: a method of validation of epidural space an animal model

Rev. mex. anestesiol; 20 (3), 1997
El cada vez más frecuente abordaje del espacio epidural o intratecal con fines diagnósticos, pronósticos y/o terapéuticos, que permitan la invasión de éstos en forma aguda o crónica obligan a identificar la ubicación de los catéteres instalados y la posible distribución de los agentes depositad...

Effect of high-dose fentanyl on renal function in dogs

Säo Paulo med. j; 115 (3), 1997
Our objective was to determine the effects of high-dose fentanyl on canine renal function (RF). We anesthetized with sodium pentobarbital (SP) 16 dogs, randomly divided into 2 groups:in G1, SP was given alone, and in G2, combined with 0.05 mg.kg(-1) fentanyl. All animals were ventilated artificially and ...

Efeitos do alopurinol em rins isquêmicos de cäes anestesiados com pentobarbital sódico

Em 16 cäes, anestesiados previamente com pentobarbital sódico (30 mg.kg(-1) de peso corporal) para preparaçäo cirúrgica com nefrectomia direita, cateterismos e instalaçäo dos aparelhos de registro, submetidos à expansäo do volume extracelular (1 ml.kg(-1).min(-1)) e à respiraçäo com pressäo ...