Results: 57

Mecanismos de resistencia a la colistina, la nitrofurantoína y la fosfomicina en Enterobacterales

Acta méd. costarric; 65 (2), 2023
Resumen Las enterobacterias son un grupo amplio y heterogéneo de bacilos Gram negativos que se aíslan de forma rutinaria en el laboratorio clínico y se asocian a una gran cantidad de cuadros clínicos. Aquellas resistentes a antibióticos de última línea, como a los carbapenémicos, representan un ...

Resistencia enzimática en Pseudomonas aeruginosa, aspectos clínicos y de laboratorio

Rev. chil. infectol; 38 (1), 2021
Resumen Pseudomonas aeruginosa es uno de los principales patógenos que causa infecciones asociadas a la atención en salud (IAAS). Su capacidad de adaptación, diseminación, resistencia intrínseca a los antimicrobianos y de adquirir nuevos mecanismos a través de elementos genéticos móviles, hacen q...

Respostas imunes induzidas por vacinas de DNA contra Zika e neuroadaptação de um isolado viral em camundongos para futuros testes de vacinas

Em geral, a doença causada pelo vírus Zika (ZIKV) é clinicamente semelhante às de outros arbovírus. No entanto, ocasionalmente ela é associada a síndromes neurológicas como a síndrome de Guillain-Barré. Além disso, durante a gravidez a infecção pode causar a síndrome congênita do zika, com...

First report of the aac(6)-Ib-cr gene in Providencia stuartii isolates in Brazil

Abstract INTRODUCTION: The aac(6')-Ib-cr and bla KPC genes are spreading among Enterobacteriaceae species, including Providencia stuartii, in some countries of world. METHODS: These genes were investigated in 28 P. stuartii isolates from a public hospital in Recife, Pernambuco, Brazil, by PCR and seq...

Full characterization of an IncR plasmid harboring qnrSI recovered from a VIM-11-producing Pseudomonas aeruginosa

Rev. argent. microbiol; 52 (4), 2020
Abstract Metallo-p-lactamases (MBL) producing Pseudomonas aeruginosa isolates have been well characterized. Quinolones are commonly used in the treatment of carbapenem-resistant P. aeruginosa infections; however, data about PMQR in this species are scarce. The objective of this study was to report the si...

Producción de plásmidos recombinantes para su uso como controles de la técnica RT-PCR para el diagnósticode los virus Chikungunya y Zika

El diagnóstico molecular de arbovirus es indispensable para identificar agentes etiológicos, particularmente en zonas endémicas para al menos uno de ellos. Estas deben ser validadas con controles positivos, los cuales están clásicamente representados por virus vivos, cuya obtención puede ser riesgo...

Mobile genetic elements associated with carbapenemase genes in South American Enterobacterales

Braz. j. infect. dis; 24 (3), 2020
ABSTRACT Introduction: Carbapenem resistance in members of order Enterobacterales is a growing public health problem causing high mortality in developing and industrialized countries. Its emergence and rapid propagation worldwide was due to both intercontinental spread of pandemic strains and horizontal...

Caracterização fenotípica e genotípica de cepas de Salmonella spp. e subtipagem molecular de plasmídeos carreando genes de beta-lactamases de espectro estendido e AmpC

Salmonella spp. são reconhecidas como um dos mais importantes patógenos que ocasionam doença entérica, sendo a terceira causa de morte entre as doenças transmitidas por alimentos (DTAs). A maior preocupação atual deve-se ao aumento da resistência aos beta-lactâmicos, e a produção de beta-lacta...

High plasmid variability, and the presence of IncFIB, IncQ, IncA/C, IncHI1B, and IncL/M in clinical isolates of Klebsiella pneumoniae with bla KPC and bla NDM from patients at a public hospital in Brazil

Abstract INTRODUCTION Antibiotic resistance in carbapenemase-producing Klebsiella pneumoniae is acquired and disseminated mainly by plasmids. Therefore, we aimed to investigate the occurrence of carbapenemase genes, analyze the genetic diversity by ERIC-PCR, and examine the most common plasmid incompat...

Identification of plasmid IncQ1 and NTEKPC-IId harboring bla KPC-2 in isolates from Klebsiella pneumoniae infections in patients from Recife-PE, Brazil

Abstract INTRODUCTION: This study investigated the genetic environment of bla KPC-2 in Klebsiella pnemoniae multi-drug resistant clinical isolates. METHODS: Four carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using...