Abstract Current trends in science education recommend the complementary use of virtual and hands-on methods of teaching. In neurobiology, for instance, there is a plethora of virtual laboratories and simulators that can be readily combined with traditional physical labs. Unfortunately, physical laborato...
Resumo A Ranolazina (RANO), conhecida na clínica como Ranexa, é um fármaco que previne a arritmia cardíaca através da inibição da corrente de sódio tardia (INaT). Um gradiente de voltagem transmural do canal Nav1.5 encontra-se na parede ventricular esquerda do coração. Assim, investigamos os ef...
ABSTRACT Quantitative electromyography is an important tool to evaluate myopathies, and some difficult-to-treat asthmatic patients may have a subclinical corticosteroid myopathic process, using only inhaled corticosteroid, according to some studies. In this report, diaphragm quantitative electromyography...
Potenciales de Acción/fisiología,
Corticoesteroides/uso terapéutico,
Asma/tratamiento farmacológico,
Asma/fisiopatología,
Estudios de Casos y Controles,
Diafragma/fisiopatología,
Electromiografía/métodos,
Valores de Referencia,
Estadísticas no Paramétricas,
Factores de Tiempo,
Resultado del Tratamiento
Abstract Purpose: To evaluate if the type of electrode (needle vs. surface) affects the electromyoneurography parameters in rats. Methods: Twenty male rats were anesthetized, then compound muscle action potential were recorded using a Neuropack S1 MEB- 9400©. All animals were submitted to two electro...
ABSTRACT Objective The aim of this study was to obtain data on phrenic neuroconduction and electromyography of the diaphragm muscle in difficult-to-treat asthmatic patients and compare the results to those obtained in controls. Methods The study consisted of 20 difficult-to-treat asthmatic patients com...
Potenciales de Acción/fisiología,
Factores de Edad,
Asma/diagnóstico por imagen,
Asma/fisiopatología,
Estudios de Casos y Controles,
Diafragma/fisiopatología,
Electromiografía/métodos,
Conducción Nerviosa/fisiología,
Nervio Frénico/diagnóstico por imagen,
Nervio Frénico/fisiopatología,
Enfermedad Pulmonar Obstructiva Crónica/fisiopatología,
Radiografía Torácica,
Valores de Referencia,
Pruebas de Función Respiratoria/métodos,
Estadísticas no Paramétricas
Testosterone synthesis within Leydig cells is a calcium-dependent process. Intracellular calcium levels are regulated by different processes including ATP-activated P2X purinergic receptors, T-type Ca2+ channels modulated by the luteinizing hormone, and intracellular calcium storages recruited by a calci...
Potenciales de Acción,
Adenosina Trifosfato/fisiología,
Arginina/administración & dosificación,
Arginina/metabolismo,
Células Cultivadas,
GMP Cíclico/administración & dosificación,
GMP Cíclico/análogos & derivados,
GMP Cíclico/metabolismo,
Células Intersticiales del Testículo/fisiología,
NG-Nitroarginina Metil Éster/administración & dosificación,
NG-Nitroarginina Metil Éster/metabolismo,
Óxido Nítrico/biosíntesis,
Óxido Nítrico/fisiología,
Técnicas de Placa-Clamp,
Receptores Purinérgicos/metabolismo,
Tionucleótidos/administración & dosificación,
Tionucleótidos/metabolismo
ABSTRACT Objective: The aim of the present study was to define normative data of phrenic nerve conduction parameters of a healthy population. Methods: Phrenic nerve conduction studies were performed in 27 healthy volunteers. Results: The normative limits for expiratory phrenic nerve compound muscle ac...
BACKGROUND: The antiepileptic drugs carbamazepine and gabapentin are effective in treating neuropathic pain and trigeminal neuralgia. In the present study, to analyze the effects of carbamazepine and gabapentin on neuronal excitation in the spinal trigeminal subnucleus caudalis (Sp5c) in the medulla oblo...
Aminas/farmacología,
Anticonvulsivantes/farmacología,
Carbamazepina/farmacología,
Ácidos Ciclohexanocarboxílicos/farmacología,
Neuralgia del Trigémino/tratamiento farmacológico,
Núcleo Espinal del Trigémino/efectos de los fármacos,
Imagen de Colorante Sensible al Voltaje,
Ácido gamma-Aminobutírico/farmacología,
Potenciales de Acción/efectos de los fármacos,
Potenciales de Acción/fisiología,
Vías Aferentes/efectos de los fármacos,
Vías Aferentes/fisiología,
Neuralgia del Trigémino/fisiopatología,
Núcleo Espinal del Trigémino/fisiopatología,
Animales Recién Nacidos,
Gabapentina,
Ratas Wistar
Objetivo—Analisar o comportamento dos potenciais tardios (Pr) em pacientes submetidos com sucesso a trombólise coronária. Casuística e Métodos—Trinta e cinco pacientes com infarto do miocárdio, 32 (91,4%) do sexo masculino com idades entre 33 e 68 (média de 52,6) anos. Trombólise coronária fo...
