Fontana, Camilla Maria;
Terrin, Francesca;
Facchinello, Nicola;
Meneghetti, Giacomo;
Dinarello, Alberto;
Gambarotto, Lisa;
Zuccarotto, Annalisa;
Caichiolo, Micol;
Brocca, Ginevra;
Verin, Ranieri;
Nazio, Francesca;
Carnevali, Oliana;
Cecconi, Francesco;
Bonaldo, Paolo;
Valle, Luisa Dalla.
BACKGROUND: AMBRA1 is an intrinsically disordered protein, working as a scaffold molecule to coordinate, by protein-protein interaction, many cellular processes, including autophagy, mitophagy, apoptosis and cell cycle progression. The zebrafish genome contains two ambra1 paralogous genes (a and b), both...
Diferenciación Sexual,
Pez Cebra/genética,
Pez Cebra/metabolismo,
Proteínas Adaptadoras Transductoras de Señales/metabolismo,
Células Germinativas/metabolismo,
Mamíferos/genética,
Mamíferos/metabolismo,
ARN Mensajero/metabolismo,
Reproducción,
Proteínas de Pez Cebra/genética,
Proteínas de Pez Cebra/metabolismo
Circular RNAs (circRNAs) have been extensively elucidated with regard to their significant implications in oral squamous cell carcinoma (OSCC). This study performed the functional investigation of circRNA dehydrogenase E1 and transketolase domain containing 1 (circDHTKD1) in OSCC. RNA expression levels o...
ABSTRACT A 65-year-old female patient was referred to our hospital for evaluation for cataract surgery. Her past medical history included corrective jaw surgeries for facial deformities that developed during infancy and persisted through early adulthood. A complete ophthalmological examination revealed b...
Abstract Although periodontitis is one of the commonest infectious inflammatory diseases in humans, the mechanisms involved with its immunopathology remain ill understood. Numerous molecules may induce inflammation and lead to bone resorption, secondary to activation of monocytes into osteoclasts. TACE (...
ABSTRACT Background: Previous studies have shown an association between polymorphisms of the BAT1-NF-κB inhibitor-like-1 (NFKBIL1)-LTA genomic region and susceptibility to myocardial infarction and acute coronary syndrome (ACS). Objective: The objective of the study was to study the role of three ...
Síndrome Coronario Agudo/genética,
Proteínas Adaptadoras Transductoras de Señales/genética,
Estudios de Casos y Controles,
ARN Helicasas DEAD-box/genética,
Frecuencia de los Genes,
Predisposición Genética a la Enfermedad,
Genotipo,
Linfotoxina-alfa/genética,
México,
Infarto del Miocardio/genética,
Polimorfismo de Nucleótido Simple
SUMMARY OBJECTIVE Sclerostin is a glycoprotein that plays a catabolic role in bone and is involved in the regulation of bone metabolism by increasing the osteoclastic bone resorption. In this study, serum sclerostin levels were measured in chronic otitis media (COM) with and without cholesteatoma, assu...
Zhu, Qing;
Li, Jingchao;
Wu, Qi;
Cheng, Yongxia;
Zheng, Huizhe;
Zhan, Tao;
Wang, Hongwei;
Yang, Yue;
Wang, Hongyan;
Liu, Ye;
Guo, Sufen.
BACKGROUND: LincRNAs have been revealed to be tightly associated with various tumorigeneses and cancer development, but the roles of specific lincRNA on tumor-related angiogenesis was hardly studied. Here, we aimed to investigate whether linc-OIP5 in breast cancer cells affects the angiogenesis of HUVECs...
Proteínas Adaptadoras Transductoras de Señales/metabolismo,
Neoplasias de la Mama/patología,
Células Endoteliales de la Vena Umbilical Humana/citología,
Neuropilina-1/metabolismo,
Receptores Notch/metabolismo,
Factores de Transcripción/metabolismo,
Microambiente Tumoral,
Neoplasias de la Mama/metabolismo,
Western Blotting,
Línea Celular Tumoral,
Inmunohistoquímica,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Reacción en Cadena de la Polimerasa de Transcriptasa Inversa,
Transducción de Señal
Hou, Jian;
Yue, Yuan;
Hu, Bo;
Xu, Guangtao;
Su, Ruibing;
Lv, Linhua;
Huang, Jiaxing;
Yao, Jianping;
Guan, Yuanjun;
Wang, Keke;
Wu, Zhongkai.
Abstract Objective: To determine the role of the dishevelled binding antagonist of beta catenin 1 (DACT1) in the cytoskeletal arrangement of cardiomyocytes in atrial fibrillation (AF). Methods: The DACT1 expression and its associations with the degree of fibrosis and β-catenin in valvular disease ...
Proteínas Adaptadoras Transductoras de Señales/genética,
Proteínas Adaptadoras Transductoras de Señales/metabolismo,
Fibrilación Atrial/genética,
Fibrilación Atrial/metabolismo,
Fibrilación Atrial/fisiopatología,
Movimiento Celular,
Conexina 43/genética,
Conexina 43/metabolismo,
Citoesqueleto/metabolismo,
Inmunohistoquímica,
Miocitos Cardíacos/citología,
Proteínas Nucleares/genética,
Proteínas Nucleares/metabolismo
Yes-associated protein (YAP) is an important regulator of cellular proliferation and transdifferentiation. However, little is known about the mechanisms underlying myofibroblast transdifferentiation in dilated cardiomyopathy (DCM). We investigated the role of YAP in the pathological process of cardiac ma...
Proteínas Adaptadoras Transductoras de Señales/antagonistas & inhibidores,
Proteínas Adaptadoras Transductoras de Señales/efectos de los fármacos,
Proteínas Adaptadoras Transductoras de Señales/fisiología,
Angiotensina II/farmacología,
Western Blotting,
Cardiomiopatía Dilatada/patología,
Cardiomiopatía Dilatada/fisiopatología,
Proteínas de Ciclo Celular,
Diferenciación Celular,
Transdiferenciación Celular/efectos de los fármacos,
Modelos Animales de Enfermedad,
Ecocardiografía,
Ratones Endogámicos BALB C,
Microscopía Fluorescente,
Miofibroblastos/efectos de los fármacos,
Miofibroblastos/fisiología,
Fosfoproteínas/antagonistas & inhibidores,
Fosfoproteínas/fisiología,
Ratas Sprague-Dawley,
Porcinos
Abstract Cementum is the mineralized tissue covering the tooth root that functions in tooth attachment and post-eruptive adjustment of tooth position. It has been reported to be highly similar to bone in several respects but remains poorly understood in terms of development and regeneration. Here, we inv...
Proteínas Adaptadoras Transductoras de Señales,
Análisis de Varianza,
Proteínas Morfogenéticas Óseas/análisis,
Proteínas Morfogenéticas Óseas/genética,
Técnicas de Cultivo de Célula/métodos,
Línea Celular,
Cemento Dental/metabolismo,
Proteínas de la Matriz Extracelular/análisis,
Proteínas de la Matriz Extracelular/genética,
Técnica del Anticuerpo Fluorescente,
Expresión Génica,
Marcadores Genéticos/genética,
Glicoproteínas de Membrana/análisis,
Glicoproteínas de Membrana/genética,
Diente Molar/citología,
Fosfatos/farmacología,
Fosfoproteínas/análisis,
Fosfoproteínas/genética,
Sialoglicoproteínas/análisis,
Sialoglicoproteínas/genética,
Factores de Tiempo,
Cemento Dental/citología
