O carcinoma papilífero de tireoide (CPT) é a neoplasia maligna mais comum na glândula tireoide. Embora essas lesões geralmente tenham um excelente prognóstico, há casos que apresentam características clínico-patológicas agressivas, com alto índice de metástase linfonodal e recorrência. Diante...
Ahmad, M;
Hameed, Y;
Khan, M;
Usman, M;
Rehman, A;
Abid, U;
Asif, R;
Ahmed, H;
Hussain, M S;
Rehman, J U;
Asif, H M;
Arshad, R;
Atif, M;
Hadi, A;
Sarfraz, U;
Khurshid, U.
Abstract Cancer is a fatal malignancy and its increasing worldwide prevalence demands the discovery of more sensitive and reliable molecular biomarkers. To investigate the GINS1 expression level and its prognostic value in distinct human cancers using a series of multi-layered in silico approach may help...
Abstract Nucleotide excision repair (NER) acts repairing damages in DNA, such as lesions caused by cisplatin. Xeroderma Pigmentosum complementation group C (XPC) protein is involved in recognition of global genome DNA damages during NER (GG-NER) and it has been studied in different organisms due to its i...
Alsagaby, Suliman A;
Brewis, Ian A;
Vijayakumar, Rajendran;
Alhumaydhi, Fahad A;
Alwashmi, Ameen S;
Alharbi, Naif K;
Al Abdulmonem, Waleed;
Premanathan, Mariappan;
Pratti, Guy;
Fegan, Christopher;
Pepper, Christopher;
Brennan, Paul.
BACKGROUND: Chronic lymphocytic leukaemia (CLL) is a neoplasm of B-cells characterized by variable prognosis. Exploring the proteome of CLL cells may provide insights into the disease. Therefore, eleven proteomics experiments were conducted on eleven primary CLL samples. RESULTS: We reported a CLL proteo...
SUMMARY OBJECTIVE: Bladder cancer under the age of 40 is extremely rare. Bladder cancer development involves complex and multi-stage processes, one of which is the DNA damage repair mechanism. In this retrospective study, we aimed to evaluate the histopathological features of bladder urothelial carcinom...
Current understanding of the genetic factors contributing to the etiology of non-syndromic craniosynostosis (NSC) remains scarce. The present work investigated the presence of variants in ALX4, EFNA4, and TWIST1 genes in children with NSC to verify if variants within these genes may contribute to the occ...
Hoyos-Bachiloglu, Rodrigo;
Rojas, Jorge;
Borzutzky, Arturo;
Hernández, Pamela;
Vinet, Ana María;
Bustos, Paula;
Fernández, Fabiola;
Lagos, Macarena;
Strickler, Alexis;
Marinovic, María Angélica;
Casado, Cristina;
Poli, María Cecilia;
King, Alejandra.
INTRODUCCIÓN: La inmunodeficiencia combinada severa (IDCS) corresponde a una de las formas más graves de inmunodeficiencia primaria, existiendo escasos datos nacionales sobre ésta. OBJETIVO: describir la epidemiología, complicaciones, pronóstico y uso de la vacuna BCG en pacientes chilenos con IDCS....
Vacuna BCG/administración & dosificación,
Inmunodeficiencia Combinada Grave/epidemiología,
Vacunación/estadística & datos numéricos,
Vacuna BCG/efectos adversos,
Trasplante de Médula Ósea/estadística & datos numéricos,
Chile,
Proteínas de Unión al ADN/genética,
Diagnóstico Tardío,
Mutación,
Proteínas Nucleares/genética,
Pronóstico,
Estudios Retrospectivos,
Inmunodeficiencia Combinada Grave/inmunología,
Inmunodeficiencia Combinada Grave/terapia,
Linfocitos T/inmunología,
Factores de Tiempo,
Vacunación/efectos adversos
ABSTRACT Purpose: Testicular germ cells tumor (TGCT) are associated with a high cure rate and are treated with platinum-based chemotherapy. However, a group of testicular cancer patients may have a very unfavorable evolution and insensitivity to the main therapeutic agent chemotherapy (CT) cisplatin. Th...
Protocolos de Quimioterapia Combinada Antineoplásica,
Cisplatino,
Reparación del ADN,
Proteínas de Unión al ADN,
Resistencia a Antineoplásicos/fisiología,
Endonucleasas,
Proteínas de Unión al GTP/metabolismo,
Neoplasias Pulmonares,
FN-kappa B/metabolismo,
Pronóstico,
Estudios Retrospectivos,
Neoplasias Testiculares,
Transglutaminasas/metabolismo
Abstract Instruction: Noise-induced hearing loss is a leading occupational disease caused by gene-environment interaction. The Grainy Like 2, GRHL2, is a candidate gene. In this regard, many studies have evaluated the association between GRHL2 and noise-induced hearing loss, although the results are amb...
