Results: 10

Actualización en fibrosis quística: uso de exacaftor/tezacaftor/ivacaftor/en pacientes con fibrosis quística port-trasplante pulmonar

El uso de moduladores de CFTR en pacientes con fibrosis quística post trasplante pulmonar es un tema todavía controversial. Varias publicaciones reportan los beneficios del modulador elexacaftor/tezacaftor/ivacaftor en los síntomas extrapulmonares de ...

Individualized treatment for allergic rhinitis based on key nasal clinical manifestations combined with histamine and leukotriene D4 levels

Abstract Introduction The types of allergic rhinitis are roughly classified based on the causative antigens, disease types, predilection time, and symptom severity. Objective To examine the clinical typing and individualized treatment approach for allergic rhinitis and to determine the optimal treatmen...

Efficacy of the 7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline derivative against infection caused by Leishmania amazonensis

Abstract INTRODUCTION: The drugs currently available for leishmaniasis treatment have major limitations. METHODS: In vitro and in vivo studies were performed to evaluate the effect of a quinoline derivative, Hydraqui (7-chloro-4-(3-hydroxy-benzilidenehydrazo)quinoline, against Leishmania amazonensis. I...

lncRNA PCGEM1 strengthens anti-inflammatory and lung protective effects of montelukast sodium in children with cough-variant asthma

Braz. j. med. biol. res; 53 (7), 2020
Montelukast sodium is an effective and well-tolerated anti-asthmatic drug. Long non-coding RNAs (lncRNAs) are involved in the treatment of asthma. Therefore, this study aimed to investigate the effect of montelukast sodium on children with cough-variant asthma (CVA) and the role of lncRNA prostate cancer...

Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients

Abstract INTRODUCTION: Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for mal...

Galunisertib (LY2157299), a transforming growth factor-β receptor I kinase inhibitor, attenuates acute pancreatitis in rats

Braz. j. med. biol. res; 49 (9), 2016
Galunisertib (LY2157299), a selective ATP-mimetic inhibitor of TGF-β receptor I (TGF-βRI), is the only known TGF-β pathway inhibitor. In the present study, we investigated the effect of galunisertib on taurocholate (TAC)-induced acute pancreatitis (AP) in rats, and the role of TGF-β a...

Eficácia clínica e microbiológica da norfloxacina tópica 0,3 no tratamento de infecçöes oculares externas
Clinical and microbiological effectiveness of topical norfloxacin 0,3

Arq. bras. oftalmol; 54 (5), 1991
Foi avaliada a eficácia clínica e microbiológica da norfloxacina a 0,3% contra 24 cepas de Staphylococcus aureus e 15 cepas de anaeróbios isolados de 27 pacientes portadores de infecçäo ocular superficial externa. Comparou-se a eficácia microbiológica da norfloxacina com as da gentamicina, tobram...

Estudo terapêutico comparativo entre a penicilina G-procaína mais probenicide e a rosoxacina e o tianfenicol no tratamento da gonococcia aguda em homens e mulheres
Comparative therapeutic study between G procaine penicillin and probenicid, rosoxacin and thianphenicol in the treatment of acute gonococcal infection in males and females

Ars méd; 13 (1/4), 1986
Num estudo do tipo controlado-aberto e randomizado, comparou-se o efeito terapêutico e a tolerância entre a Penicilina G - Procaína + Probenicide e a Rosoxacina e o Tianfenicol no tratamento da gonococcia aguda em dose única ("tratamento minuto"), tanto em homens quanto em mulheres. Discutem-se as ca...