We developed poly-ε-caprolactone (PCL)-based nanoparticles containing D-α-tocopherol polyethylene glycol-1000 succinate (TPGS) or Poloxamer 407 as stabilizers to efficiently encapsulate genistein (GN). Two formulations, referred to as PNTPGS and PNPol, were prepared using nanoprecipitation. They were c...
Abstract Solid dispersions (SDs) of ursolic acid (UA) were developed using polyvinylpyrrolidone K30 (PVP K30) in combination with non-ionic surfactants, such as D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) or poloxamer 407 (P407) with the aim of enhancing solubility and in vitro release ...
Abstract In this study, orodispersible films formed from hydroxypropyl methylcellulose (HPMC) E6 (2, 2.5, and 3%) and plasticizers ((glycerin (Gly), propylene glycol (PP), or polyethylene glycol (PEG)), containing doxazosin mesylate, were prepared by the solvent casting method and characterized. Design ...
Abstract Natural products are considered an important source of the therapeutic arsenal currently available. Among these alternatives are the seeds of Ambrosia peruviana (altamisa), whose extract has shown an anti-inflammatory effect. The main objective of this work was to perform a preformulation study ...
A introdução da liga NiTi na endodontia proporcionou a fabricação de instrumentos
com excelentes propriedades mecânicas, e uma das principais características é a
possibilidade de alteração das temperaturas de transformação da liga, o qual pode
possibilitar a presença de martensita em temperat...
A engenharia de tecidos ósseos é um ramo importante da medicina regenerativa e
envolve o desenvolvimento de arcabouços com composição e arquitetura favoráveis
à integração celular, além do estudo de fatores capazes de promover a adesão e
proliferação celular, incluindo estímulos químicos e...
O objetivo deste trabalho foi preparar e caracterizar nanocarreadores via auto-organização a partir da pectina de citros e lisozima para o encapsulamento da β-lactose. Foram estudadas três condições de interação entre os biopolímeros variando a razão molar pectina/lisozima (3:1, 2:1, 1:1, 1:2 e...
Abstract To investigate structure-property relationship of polymer-based curcumin solid dispersion (SD), three acrylic polymers were used to formulate curcumin SD by solvent evaporation method. Curcumin Eudragit EPO SD (cur@EPO), curcumin Eudragit RS PO SD (cur@RSPO) and curcumin Eudragit RL PO SD (cur@R...
Curcumina/análisis,
Citrus sinensis/clasificación,
Concentración de Iones de Hidrógeno,
Color,
Difracción de Rayos X/instrumentación,
Espectroscopía Infrarroja por Transformada de Fourier,
Evaporación/clasificación,
Métodos,
Polímeros,
Solventes/administración & dosificación,
Técnicas In Vitro/métodos,
Rastreo Diferencial de Calorimetría/métodos
Abstract Design of experiment (DoE) is a useful time and cost-effective tool for analyzing the effect of independent variables on the formulation characteristics. The aim of this study is to evaluate the effect of the process variables on the characteristics involved in the preparation of Diclofenac Sodi...
Nanopartículas/análisis,
Optimización de Procesos,
Análisis de Fourier,
Costos y Análisis de Costo/métodos,
Diclofenaco/análisis,
Espectroscopía Infrarroja por Transformada de Fourier,
Metodología como un Tema,
Microscopía Electrónica de Rastreo/métodos,
Preparaciones Farmacéuticas,
Técnicas In Vitro/instrumentación,
Rastreo Diferencial de Calorimetría/instrumentación
Ribeiro, Priscilla Tobias;
Pedrosa, Tatiana do Nascimento;
Chaves, Francisco Celio Maia;
José Quintans-Júnior, Lucindo;
Araújo, Adriano Antunes de Souza;
Vasconcellos, Marne Carvalho de;
Maria-Engler, Silvya Stuchi;
Silva, Cláudia Cândida;
Silva, Felipe Moura Araújo da;
Koolen, Héctor Henrique Ferreira;
Lima, Emerson Silva;
Lima, Ádley Antonini Neves de.
Abstract Passiflora nitida Kunth, an Amazonian Passiflora species, is little studied, although the specie’s high biological potential. Herein the plant’s pharmacognostic characterization, extract production, antioxidant potential evaluation, and application of this extract in cosmetic products is rep...
Passiflora/clasificación,
Extractos Vegetales/análisis,
Hojas de la Planta/efectos adversos,
Monofenol Monooxigenasa/antagonistas & inhibidores,
Cosméticos/clasificación,
Antioxidantes/efectos adversos,
Compuestos Fenólicos,
Melaninas,
Rayos X/efectos adversos,
Termogravimetría/métodos,
Rastreo Diferencial de Calorimetría/métodos
