“Gordolobo” (Gnaphalium sp) is a Mexican medicinal plant understudied for the treatment of diabetes; therefore, the aim was to evaluate the chloroformic extract of G sp. (CEG) in alloxan-induced diabetic rats. Sesquiterpene lactones, polyphenolic compounds, triterpenes and steroids, api...
Montanoa tomentosa is used in traditional Mexican medicine to treat reproductive and mood disorders. Preclinical studies support the idea that acute administration of M. tomentosa induces an antidepressant-like response that may be related to oxytocin activation in hypothalamic cells, however...
Orijin bitters, Hibiscus sabdariffa and Zingiber officinale roscoe have been reported to possess various medicinal properties. The aim of the study is to evaluate their effects on the kidney of adult wistar rats. Methodology: thirty rats were randomly divided into 6 groups...
Riñón/patología,
Fitoterapia/métodos,
Zingiber officinale/química,
Hibiscus/química,
Ratas Wistar,
Extractos Vegetales/química,
Fitoquímicos/química,
Antioxidantes/uso terapéutico,
Proyectos de Investigación,
Dosificación,
Técnicas Histológicas,
Fotomicrografía,
Ácido Peryódico/metabolismo
Objetivo: Avaliar a eficácia do filtro de proteção de luz azul na proteção de retinas de
ratos Wistar expostos a luz azul emitida por um aparelho fotopolimerizador LED de
alta potência. Material e métodos: Nove ratos Wistar foram utilizados na pesquisa e
suas estruturas oculares foram os objetos d...
SUMMARY: Cadmium (Cd) is a toxic element that accumulates in kidney and liver. L-carnitine(LC) is a natural compound that has been shown to exhibit antioxidant activity. Aim of this study was to investigate the effect of L-carnitine against cadmium-induced changes in liver and kidney tissues in prepubert...
SUMMARY: As the economy develops and living standards improve, overweight and obesity are increasingly prevalent. Currently, weight-loss medications are primarily administered orally or intravenously, which can result in poor targeting, low bioavailability, frequent administration, and high toxicity and ...
Natación,
Frío,
Pioglitazona/administración & dosificación,
Proteínas Desacopladoras Mitocondriales/genética,
Nitrógeno de la Urea Sanguínea,
Ratas Wistar,
Músculo Esquelético,
Complejo IV de Transporte de Electrones,
Electroforesis,
Reacción en Cadena en Tiempo Real de la Polimerasa,
d0123330
SUMMARY: Etoposide is an effective antimitotic and antineoplastic agent used to treat various human malignancies. In the present study, Etoposide was injected intraperitoneally into the rats at 1 mg/kg/day for 52 days (52 doses). The control animals received physiological saline (0.5 ml) intraperitoneall...
Etopósido/administración & dosificación,
Etopósido/farmacología,
Peso Corporal/efectos de los fármacos,
Tamaño de los Órganos/efectos de los fármacos,
Peroxidación de Lípido,
Antioxidantes/administración & dosificación,
Antioxidantes/farmacología,
Hígado/efectos de los fármacos,
Hígado/ultraestructura,
Riñón/efectos de los fármacos,
Riñón/ultraestructura,
Corazón/efectos de los fármacos,
Miocardio/ultraestructura,
Sistema Enzimático del Citocromo P-450/análisis,
Citocromos b5/análisis,
Ratas Wistar,
Microscopía,
Antineoplásicos Fitogénicos
SUMMARY: Stroke is the leading cause of acquired physical disability in adults and second leading cause of mortality throughout the world. Treatment strategies to curb the effects of stroke would be of great benefit. Pongamia pinnata is a recent attraction in medicine, owing to its abundant medicinal ben...
Millettia/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Accidente Cerebrovascular/tratamiento farmacológico,
Ratas Wistar,
Modelos Animales de Enfermedad,
Corteza Cerebral/efectos de los fármacos,
Isquemia Encefálica/tratamiento farmacológico,
Factor Neurotrófico Derivado del Encéfalo/genética,
Factor Neurotrófico Derivado de la Línea Celular Glial/genética,
Factor 1 Inducible por Hipoxia/genética,
FN-kappa B,
Administración Oral,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factores de Crecimiento Nervioso/administración & dosificación
Bisphenol A (BPA) have been reported to induced reprotoxicity in rats. This study was conducted to find out the ameliorative properties of aqueous extract of Cyperus esculentus (tigernut) on BPA induced testicular toxicity in Wistar rats.Methods: Twenty male rats were divided randomly into 4 groups (n=5)...
Enfermedades Testiculares/prevención & control,
Testículo/efectos de los fármacos,
Cyperus/química,
Extractos Vegetales/farmacología,
Extractos Vegetales/aislamiento & purificación,
Enfermedades Testiculares/inducido químicamente,
Enfermedades Testiculares/metabolismo,
Enfermedades Testiculares/patología,
Testículo/metabolismo,
Antiinflamatorios/aislamiento & purificación,
Antiinflamatorios/farmacología,
Antioxidantes/aislamiento & purificación,
Antioxidantes/farmacología,
Modelos Animales de Enfermedad,
Bisfenol A Glicidil Metacrilato/efectos adversos,
Ratas Wistar,
Espermatozoides/efectos de los fármacos,
Espermatozoides/metabolismo,
Espermatozoides/patología
SUMMARY: Obesity-related pathophysiologies such as insulin resistance and the metabolic syndrome show a markedly increased risk for type 2 diabetes and atherosclerotic cardiovascular disease. This risk appears to be linked to alterations in adipose tissue function, leading to chronic inflammation and the...
Brassica rapa/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/uso terapéutico,
Resistencia a la Insulina,
Tejido Adiposo/efectos de los fármacos,
Grasa Intraabdominal,
Inflamación,
Ratas Wistar,
Obesidad/tratamiento farmacológico,
Diabetes Mellitus Tipo 2/tratamiento farmacológico,
Glucosa/toxicidad,
Lípidos/toxicidad
