SUMMARY: Cadmium (Cd) is a toxic element that accumulates in kidney and liver. L-carnitine(LC) is a natural compound that has been shown to exhibit antioxidant activity. Aim of this study was to investigate the effect of L-carnitine against cadmium-induced changes in liver and kidney tissues in prepubert...
SUMMARY: As the economy develops and living standards improve, overweight and obesity are increasingly prevalent. Currently, weight-loss medications are primarily administered orally or intravenously, which can result in poor targeting, low bioavailability, frequent administration, and high toxicity and ...
Natación,
Frío,
Pioglitazona/administración & dosificación,
Proteínas Desacopladoras Mitocondriales/genética,
Nitrógeno de la Urea Sanguínea,
Ratas Wistar,
Músculo Esquelético,
Complejo IV de Transporte de Electrones,
Electroforesis,
Reacción en Cadena en Tiempo Real de la Polimerasa,
d0123330
SUMMARY: Etoposide is an effective antimitotic and antineoplastic agent used to treat various human malignancies. In the present study, Etoposide was injected intraperitoneally into the rats at 1 mg/kg/day for 52 days (52 doses). The control animals received physiological saline (0.5 ml) intraperitoneall...
Etopósido/administración & dosificación,
Etopósido/farmacología,
Peso Corporal/efectos de los fármacos,
Tamaño de los Órganos/efectos de los fármacos,
Peroxidación de Lípido,
Antioxidantes/administración & dosificación,
Antioxidantes/farmacología,
Hígado/efectos de los fármacos,
Hígado/ultraestructura,
Riñón/efectos de los fármacos,
Riñón/ultraestructura,
Corazón/efectos de los fármacos,
Miocardio/ultraestructura,
Sistema Enzimático del Citocromo P-450/análisis,
Citocromos b5/análisis,
Ratas Wistar,
Microscopía,
Antineoplásicos Fitogénicos
SUMMARY: Stroke is the leading cause of acquired physical disability in adults and second leading cause of mortality throughout the world. Treatment strategies to curb the effects of stroke would be of great benefit. Pongamia pinnata is a recent attraction in medicine, owing to its abundant medicinal ben...
Millettia/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/farmacología,
Accidente Cerebrovascular/tratamiento farmacológico,
Ratas Wistar,
Modelos Animales de Enfermedad,
Corteza Cerebral/efectos de los fármacos,
Isquemia Encefálica/tratamiento farmacológico,
Factor Neurotrófico Derivado del Encéfalo/genética,
Factor Neurotrófico Derivado de la Línea Celular Glial/genética,
Factor 1 Inducible por Hipoxia/genética,
FN-kappa B,
Administración Oral,
Reacción en Cadena en Tiempo Real de la Polimerasa,
Factores de Crecimiento Nervioso/administración & dosificación
SUMMARY: Obesity-related pathophysiologies such as insulin resistance and the metabolic syndrome show a markedly increased risk for type 2 diabetes and atherosclerotic cardiovascular disease. This risk appears to be linked to alterations in adipose tissue function, leading to chronic inflammation and the...
Brassica rapa/química,
Extractos Vegetales/administración & dosificación,
Extractos Vegetales/uso terapéutico,
Resistencia a la Insulina,
Tejido Adiposo/efectos de los fármacos,
Grasa Intraabdominal,
Inflamación,
Ratas Wistar,
Obesidad/tratamiento farmacológico,
Diabetes Mellitus Tipo 2/tratamiento farmacológico,
Glucosa/toxicidad,
Lípidos/toxicidad
In tradition
al Mexican medicine, plants from the
Montanoa
genus, family Asteraceae
(
Montanoa tomentosa
,
Montanoa grandiflora
, and
Montanoa frutescens
) have been used to induce labor
owing to their uterotonic properties like those produced by oxytocin (OXT). However, w
hether infusions ...
Abstract This study was carried out to evaluate the effect of Glutamine, as a dipeptide or a free amino acid form, on the progression of burn injuries in rats. Thirty male Wistar rats were burned with a comb metal plate heated in boiling water (98 °C) for three minutes, creating four rectangular full-th...
Abstract This study evaluated the effect of the volatile oil of Alpinia zerumbet (VOAz) on caveolin-1 gene expression and muscular fibrosis. The rats were immobilized to induce fibrosis of the gastrocnemius muscle, and they were treated with VOAz. Collagen quality was assessed by histology and the expres...
Alpinia/química,
Brasil,
Caveolina 1/metabolismo,
Colágeno/metabolismo,
Modelos Animales de Enfermedad,
Fibrosis,
Músculos/efectos de los fármacos,
Músculos/patología,
Aceites Volátiles/farmacología,
Aceites de Plantas/farmacología,
Ratas Wistar
Anti-tuberculosis drugs are reported to cause hepatotoxicity, which varies from asymptomatic rise of the hepatic enzymes. Hepatoprotective plants plays important role to protect liver. This study investigated the hepatoprotective potential of the Solanum lycopersicum in rats intoxicated with Isoniazid an...
Lemos, Rafael Silva;
Bentes, Livia Guerreiro de Barros;
Vasconcelos, Maria Eduarda dos Santos Lopes;
Tramontin, Daniela Ferreira;
Costa, Luís Vinícius Pires da;
Pimentel, Antonio Leonardo Jatahi Cavalcanti;
Araújo, Nayara Pontes de;
Andrade, Mariseth Carvalho de;
Somensi, Danusa Neves;
Barros, Rui Sérgio Monteiro de.
Purpose: To evaluate the effects on peripheral neural regeneration of the end-to-side embracing repair technique compared to the autograft repair technique in Wistar rats. Methods: Fifteen male Wistar rats were divided into three groups with five animals each: denervated group (GD), autograft group (GA)...
