SUMMARY: Spinal cord injury (SCI) usually arises from compression due to traffic accidents and falls, resulting in varying degrees of movement, sensory loss, and possible paralysis. Glabridin (Gla) is a natural compound derived from licorice. It significantly affects drug development and medicine because...
SUMMARY: Both the academic and popular worlds have paid close attention to the link between exercise and cognitive performance. It is increasingly important to understand the numerous mechanisms by which exercise might influence cognitive abilities in view of the continuous societal issues caused by agin...
Hipocampo/anatomía & histología,
Hipocampo/fisiología,
Ejercicio Físico,
Neuronas/fisiología,
Aprendizaje Espacial,
Cognición,
Plasticidad Neuronal,
Ratones Endogámicos C57BL,
Prueba del Laberinto Acuático de Morris,
Prueba de Campo Abierto,
Corteza Prefrontal
SUMMARY: Senile osteoporosis is mainly caused by reduced osteoblast differentiation and has become the leading cause of fractures in the elderly worldwide. Natural organics are emerging as a potential option for the prevention and treatment of osteoporosis. This study was designed to study the effect of ...
Resveratrol/administración & dosificación,
Resveratrol/farmacología,
Osteoporosis/tratamiento farmacológico,
Diferenciación Celular/efectos de los fármacos,
Células Madre Mesenquimatosas/efectos de los fármacos,
Células Madre Mesenquimatosas/citología,
Sirtuina 1,
Modelos Animales de Enfermedad,
Western Blotting,
Ratones Endogámicos C57BL,
Osteogénesis/efectos de los fármacos
SUMMARY: The objective of this study was to investigate the therapeutic wound healing potential and molecular mechanisms of shikonin as small molecules in vitro. A mouse burn model was used to explore the potential therapeutic effect of shikonin; we traced proliferating cells in vivo to locate the active...
Cicatrización de Heridas/efectos de los fármacos,
Quemaduras/tratamiento farmacológico,
Piel,
Modelos Animales de Enfermedad,
Técnicas In Vitro,
Fibroblastos,
Fosfatidilinositol 3-Quinasas,
Proteínas Proto-Oncogénicas c-akt,
Naftoquinonas/administración & dosificación,
Ratones Endogámicos C57BL,
Naftoquinonas/farmacología,
Proliferación Celular/efectos de los fármacos
Neuregulins (NRGs) are a family of signaling proteins that bind to receptor tyrosine kinases of the ErbB family (ErbB2 to ErbB4), which can homo- or heterodimerize depending on their structural features and cell type. Many studies have proposed that decreased NRG levels are a common characteristic of obe...
Obesidad/metabolismo,
Dieta Alta en Grasa,
Ratones Endogámicos C57BL,
Peso Corporal,
Receptores ErbB/metabolismo,
Hepatocitos,
Adipocitos,
Resistencia a la Insulina,
Neurregulinas/metabolismo,
Modelos Animales de Enfermedad,
Inmunohistoquímica,
Western Blotting
As Lesões do Nervo Periférico (LNP) representam uma significativa fonte global
de incapacidade, manifestando-se através de comprometimento sensório-motor que
resulta em impactos negativos na funcionalidade e, frequentemente, leva ao
afastamento das atividades laborais. Essas lesões podem ter origem ...
Lesões traumáticas em nervos periféricos resultam em perda parcial ou total das funções motora e sensitiva, causando consequências biopsicossociais e laborais. Após a lesão, uma série de eventos complexos iniciam-se tanto no coto proximal quanto no coto distal, a fim de possibilitar que os axôn...
La enfermedad de hígado graso no alcohólico (EHGNA) abarca desde
una acumulación simple de lípidos neutros, triacilglicéridos (TAG) y colesterol en más
del 5% de los hepatocitos, hasta una forma más avanzada llamada esteatohepatitis
no alcohólica (EHNA), la que incluye inflamación lobular, balon...
Antecedentes: La ECA2 ha mostrado ser un regulador esencial de la funcionalidad cardíaca. En un modelo experimental de insuficiencia cardíaca (IC) con Fier, modelo de coartación de aorta (COA), se encontró activación de la vía Rho-kinasa. La inhibición de esta vía con fasudil no mejoró el remode...
SUMMARY: Obesity is commonly associated with chronic tissue inflammation and skeletal muscle dysfunction. The study aimed to investigate the effects of High-Intensity Interval training (HIIT) on myokines and endoplasmic reticulum (ER) stress of diet- induced obese (DIO) mice. Three-month-old C57BL/6 male...
