Abstract Nucleotide excision repair (NER) acts repairing damages in DNA, such as lesions caused by cisplatin. Xeroderma Pigmentosum complementation group C (XPC) protein is involved in recognition of global genome DNA damages during NER (GG-NER) and it has been studied in different organisms due to its i...
Borges, Daniela de Paula;
Santos, Rinna Maria Arruda Rodrigues dos;
Velloso, Elvira Rodrigues Pereira;
Ribeiro Junior, Howard Lopes;
Larripa, Irene Beatriz;
Camacho, Maria Fernanda;
González, Jacqueline;
Pratx, Leandro Daniel Burgos;
Magalhães, Sílvia Maria Meira;
Belli, Carolina Bárbara;
Pinheiro, Ronald Feitosa.
Abstract Nucleotide excision repair pathway (NER) is an essential mechanism for single-strand breaks (SSB) repair while xeroderma pigmentosum family (XPA to XPG) is the most important system to NER. Myelodysplastic syndrome (MDS) is a heterogeneous hematological cancer characterized by cytopenias and ris...
Abstract The purpose of the current work was to assess a possible role of cytochrome P450 1A2 (CYP1A2) and N-acetyltransferase 2 (NAT2) in the metabolic activation of 2,6-dimethylaniline (2,6-DMA) and also clarify the function of DNA repair in affecting the ultimate mutagenic potency. Two cell lines, nu...
Introdução: O carcinoma endometrial (CE) foi classificado pelo sistema de Bokhman em tipos I e II com base em observações clínicas e epidemiológicas. O tipo I corresponde aos tumores de baixo grau e o tipo II aos tumores de alto grau. Adicionalmente, estudos recentes propuseram que a classificaçã...
ABSTRACT Purpose: Testicular germ cells tumor (TGCT) are associated with a high cure rate and are treated with platinum-based chemotherapy. However, a group of testicular cancer patients may have a very unfavorable evolution and insensitivity to the main therapeutic agent chemotherapy (CT) cisplatin. Th...
Protocolos de Quimioterapia Combinada Antineoplásica,
Cisplatino,
Reparación del ADN,
Proteínas de Unión al ADN,
Resistencia a Antineoplásicos/fisiología,
Endonucleasas,
Proteínas de Unión al GTP/metabolismo,
Neoplasias Pulmonares,
FN-kappa B/metabolismo,
Pronóstico,
Estudios Retrospectivos,
Neoplasias Testiculares,
Transglutaminasas/metabolismo
A síndrome do Xeroderma Pigmentoso (XP) ocorre frente à herança monogênica e bialélica de variantes germinativas patogênicas de perda ou redução de função em genes das vias de reparo por excisão de nucleotídeos ou síntese translesão. Consequentemente, é estabelecida deficiência na correç...
Abstract The DNA repair system involves genes and proteins that are essential for the maintenance of genome integrity and the consequent control of various cellular processes. Alterations in these genes and proteins play a role in tumor development and progression and might be associated with prognosis. ...
BACKGROUND NME23/NDPKs are well conserved proteins found in all living organisms. In addition to being nucleoside diphosphate kinases (NDPK), they are multifunctional enzymes involved in different processes such as DNA stability, gene regulation and DNA repair among others. TcNDPK1 is the canonical NDPK...
As lesões odontogênicas epiteliais benignas apresentam comportamento biológico heterogêneo e patogênese ainda não totalmente esclarecida. As vias de reparo do ácido desoxirribonucleico (DNA) atuam em tipos específicos de danos ao material genético, realizando o reparo e regulando diversos proces...
Objective To describe the frequency of mutations in DNA-repair genes in a southwestern Colombian population.
Methods We have designed an observational study, including 162 people from all ages from southwest Colombia. We have extracted and collected their DNA in filters. We have immersed the DNA in a...
Colombia,
ADN,
Articulación Temporomandibular,
Ataxia Telangiectasia,
Molécula de Adhesión Celular Epitelial,
Genes,
Neoplasias,
Polimorfismo de Nucleótido Simple,
Programas Informáticos,
Proteínas MutS,
Proteínas de Homeodominio,
Quinasa de Punto de Control 2,
Reparación de la Incompatibilidad de ADN,
Reparación del ADN
