Results: 5

Strontium ranelate as a possible disease-modifying osteoarthritis drug: a systematic review

Braz. j. med. biol. res; 51 (8), 2018
Considering that osteoarthritis (OA) is the most prevalent joint disease worldwide, multiple pharmacological treatments have been proposed to alter the articular structure with potential benefit in the progression of the disease. The so-called disease-modifying OA drugs have been frequently investigated ...

Strontium ranelate inhibits wear particle-induced aseptic loosening in mice

Braz. j. med. biol. res; 51 (9), 2018
The imbalance between bone formation and osteolysis plays a key role in the pathogenesis of aseptic loosening. Strontium ranelate (SR) can promote bone formation and inhibit osteolysis. The aim of this study was to explore the role and mechanism of SR in aseptic loosening induced by wear particles. Twent...

Effects of strontium ranelate on alveolar ridge morphology augmentation

Int. j. morphol; 35 (4), 2017
SUMMARY: The objective of this study was to compare the Primary and Secondary stability of immediate implant placement with Alveolar Ridge Augmentation (ARA) and Strontium Ranelate (SR) as aids to enhance the stability using Resonance Frequency Analysis (RFA). Fifty eight subjects ideal for immediate imp...

Efectos in vivo del ranelato de estroncio sobre células progenitoras de médula ósea de ratas diabéticas
In vivo effects of strontium ranelate on bone marrow progenitor cells of diabetic rats

Actual. osteol; 12 (2), 2016
La diabetes mellitus (DM) crónica se asocia con reducción en el contenido mineral óseo (osteopenia y osteoporosis). El objetivo de este trabajo fue evaluar la acción del ranelato de estroncio (RaSr) administrado por vía oral a animales control y diabéticos, sobre el potencial osteogénico de célul...

Effect of strontium ranelate on bone remodeling

Acta odontol. latinoam; 25 (2), 2012
Osteoporosis is a disease in which the microarchitecture of bone tissue deteriorates, with consequent loss of bone mass. Strontium ranelate (SrR) is currently used for treatment of the condition. SrR may have a dual effect: anabolic (stimulating pre-osteoblast replication) and anti-catabolic (reducing os...