Results: 5

The Localization of R-Spondin1 and R-Spondin 3 Peptides in Rat Hypothalamus: An Immunohistochemical Study

Int. j. morphol; 41 (6), 2023
SUMMARY: The R-spondin protein family is a group of proteins that enhance Wnt/b-catenin signaling and have pleiotropic functions in stem cell growth and development. In the literature reviews, there is no histomorphological study showing the localization and distribution of R-spondins in different hypoth...

A rare case of PLA2R- and THSD7A-positive idiopathic membranous nephropathy

J. bras. nefrol; 42 (2), 2020
ABSTRACT Idiopathic membranous nephropathy (IMN) is a frequent cause of nephrotic syndrome in adults. In terms of etiology, the condition may be categorized as primary/idiopathic or secondary. Literature on the pathophysiology of IMN has indicated the presence of autoantibodies (PLA2R and THSD7A) directe...

Avaliação da resposta imune humoral contra a proteína Trap (proteína adesiva relacionada à trombospondina) de Plasmodium vivax em populações de área endêmica brasileira

A TRAP (Proteína Adesiva Relacionada à Trombospondina) do Plasmodium spp. é essencial para a motilidade dos esporozoítos e para a invasão da glândula salivar do mosquito e do hepatócito do vertebrado. Devido ao seu importante papel biológico, a TRAP é considerada um alvo promissor para o desenvo...

MiR-106a aggravates sepsis-induced acute kidney injury by targeting THBS2 in mice model

Acta cir. bras; 34 (6), 2019
Abstract Purpose To investigate the role and related mechanisms of miR-106a in sepsis-induced AKI. Methods Serum from sepsis and healthy patients was collected, sepsis mouse model was established by cecal ligation and puncture (CLP). TCMK-1 cells were treated with lipopolysaccharide (LPS) and transfe...