El síndrome de Robinow es una enfermedad rara, de origen genético causada por mutaciones en diversos genes de la vía de señalización Wnt, entre ellos: WNT5A, DVL1, DVL3, ROR2, NXN y FZ2. El síndrome se caracteriza por anomalías craneofaciales, malformaciones en extremidades y alteraciones genitour...
Purpose: Pre-eclampsia (PE) is a pregnancy-related complication. Eucommia is effective in the treatment of hypertensive disorders in pregnancy, but the specific effects and possible mechanisms of Eucommia granules (EG) in PE remain unknown. The aim of this study was to investigate the effects and possibl...
Purpose: Esophageal squamous cell carcinoma (ESCC) is characterized by early metastasis and late diagnosis. miR-29c-3p is confirmed to repress angiogenesis in multiple tumor types. Yet, the functions of miR-29c-3p in the mechanism of ESCC angiogenesis, which were not sufficiently explored previously, wer...
O desenvolvimento do dente depende de uma série de interações sinalizadoras
recíprocas entre o epitélio oral (EO) e o ectomesênquima derivado da crista
neural, a via WNT com o TGF-β e BMP4 tem sido implicada na tumorigênese. A
via de sinalização tipo Wingless (Wnt) / β-catenina é essencial pa...
SUMMARY: The Wnt pathway is essential for the initiation of lizard tail regeneration. The regenerated lizard tails exhibit obvious morphological differences compared to the original ones. The expression of Wnt1 and Wnt2b proteins in the regenerating tail of Scincella tsinlingensis was detected by immunoh...
Cervical cancer is a common and fatal malignancy of the female reproductive system. Human papillomavirus (HPV) is the primary causal agent for cervical cancer, but HPV infection alone is insufficient to cause the disease. Actually, most HPV infections are sub-clinical and cleared spontaneously by the hos...
Cao, Jia;
Liu, Dan;
Zhao, Shiyun;
Yuan, Liwei;
Huang, Yani;
Ma, Jingwen;
Yang, Zhijuan;
Shi, Bin;
Wang, Libin;
Wei, Jun.
Although estrogen has crucial functions for endometrium growth, the specific dose and underlying molecular mechanism in intrauterine adhesion (IUA) remain unclear. In this study, we aimed to investigate the effects of estrogen on epithelial-mesenchymal transition (EMT) in normal and fibrotic endometrium,...
Macrophages play pivotal roles in host defense and immune homeostasis, which have two major functional polarization states, the classically activated M1 and the alternatively activated M2. Interleukin (IL)-17A is an immune modulator able to shape macrophage phenotypes. Wnt/β-catenin is a development...
Pouco frequente, o câncer de ovário é hoje responsável por 4% dos tumores ginecológicos, já em avanço quando diagnosticado devido ausência de métodos de rastreio e diagnóstico efetivos. A via de sinalização WNT, que se encontra alterada em cânceres, possui papel importante no câncer de ová...
O hepatoblastoma, câncer de fígado mais comum na infância, é um tumor embrionário que se supõe surgir da interrupção da diferenciação hepática durante a embriogênese. O genoma deste tipo tumoral carrega poucas alterações somáticas, principalmente aneuploidias cromossômicas e mutações em...
