Clinical Laboratory Techniques,
Primary Health Care,
Mozambique,
HIV,
Acquired Immunodeficiency Syndrome,
Rural Population,
Maternal Health Services,
Health Impact Assessment,
Tuberculosis,
Malaria,
32395,
Data Interpretation, Statistical,
Quality Assurance, Health Care,
Health Surveillance System,
Epidemiological Monitoring,
Pregnant Women,
Public Reporting of Healthcare Data
Bardají, azucena;
Sigauque, betuel;
Bruni, mlaia;
Romagosa, cleofé;
Sanz, sergi;
Mabunda, samuel;
Mandomando, inacio;
Aponte, john;
Sevene, esperança;
Alonso, pedro L;
Menéndez, clara.
Background: There is a widespread notion, based on limited information, that in areas of stable malaria transmission most pregnant women with Plasmodium falciparum infection are asymptomatic. This study aim to characterize the clinical presentation of malaria in African pregnant women and to evaluate the...
A malária é de longe a doença parasitária mais importante em Moçambique, constituindo um grave problema de saúde pública no País. Apesar de se considerar que um diagnóstico atempado e um tratamento correcto são os elementos básicos para um programa de controlo da malária bem sucedido, nas úl...
Malaria/epidemiology,
Plasmodium falciparum/parasitology,
d0006550,
Antimalarials/administration & dosage,
Malaria/prevention & control,
Malaria/diagnosis,
Amodiaquine/administration & dosage,
Chloroquine/administration & dosage,
Patients/statistics & numerical data,
Mozambique/epidemiology,
Sulfadoxine/supply & distribution,
Malaria/mortality
Aponte , john J;
Aide, pedro;
Renom, montse;
Mandomando, Inacio;
Bassat, quique;
Sacarlal, jahit;
Manaca, nelia;
Lafuente, sarah;
Barbosa, arnoldo;
Leach, amanda;
Vekemans , johan;
Lievens, marc;
Sigauque, betuel;
Dubois, marie-claude;
Demoitié, marie ange;
Sillman, marla;
McNeil, john G;
Savarese, barbara;
Macete, eusebio;
Cohen, joe;
Ballou, W ripley;
Alonso, pedro L.
Background: Malaria remains a leading global health problem that requires the improved use of existing interventions and the accelerated development of new control methods. We aimed to assess the safety, immunogenicity, and initial efficacy of the malaria vaccine RTS,S/AS02D in infants in Africa. Methods...
Menendez, clara;
Schellenberg, david;
Macete, eusebio;
Aide, pedro;
Kahigwa, elizeus;
Sanz, sergi;
Aponte, john J;
Sacarlal, jahit;
Mshinda, hassan;
Tanner, marcel;
Alonso, pedro L.
Background: Intermittent preventive treatment (IPTi) with sulphadoxine-pyrimethamine (SP) in infants resulted in different estimates of clinical malaria protection in two trials that used the same protocol in Ifakara, Tanzania, and Manhiça, Mozambique. Understanding the reasons for the discrepant result...
Macete, E;
Aponte, J. J;
Guinovart, C;
Sacarlal, J;
Ofori-Anyinam, O;
Mandomando, I;
Espasa, M;
Bevilacqua, C;
Leach, A;
Dubois, M C;
Heppner, D G;
Tello, L;
Milman, J;
Cohen, J;
Dubovsky, F;
Tornieporth, N;
Thompson, R;
Alonso, P. L.
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...
Romagosa, cleofe;
Ordi, jaume;
Saute, francisco;
Quinto, llorenc;
Machungo, fernanda;
Ismail, mamudo R;
Carrilho, carla;
Osman, nafissa;
Alonso, pedro L;
Menendez, clara.
Objective: To evaluate the impact of malaria on maternal death through the analysis of the seasonal variations of crude and malaria-specific maternal mortality rates. Methods: All maternal deaths and live births occurring at Maputo Central Hospital, located in an urban area, between January 2001 and Dece...
A malária ainda continua sendo um dos principais problemas de saúde pública em Moçambique. O
Ministério de Saúde através do Programa Nacional de Controlo da Malária delineou estratégias para a expansão
massiva de intervenções com o objectivo de acelerar a redução do peso da malária.
A aval...
Enosse, Sonia;
Dobaño, Carlota;
Quelhas, Diana;
Aponte, John J;
Lievens, Marc;
Leach, Amanda;
Sacarlal, Jahit;
Greenwood, Brian;
Milman, Jessica;
Dubovsky, Filip;
Cohen, Joe;
Thompson, Ricardo;
Ballou, W Ripley;
Alonso, Pedro L;
Conway, David J;
Sutherland, Colin J.
The candidate malaria vaccine RTS,S/AS02A is a recombinant protein containing part of the circumsporozoite protein (CSP) sequence of Plasmodium falciparum, linked to the hepatitis B surface antigen and formulated in the proprietary adjuvant system AS02A. In a recent trial conducted in children younger th...
Malaria,
T-Lymphocytes/immunology,
Parasites/parasitology,
Cells,
Malaria, Falciparum/diagnosis,
Malaria Vaccines/immunology,
Protozoan Infections/transmission,
Malaria, Falciparum/transmission,
Malaria, Falciparum/prevention & control,
Mozambique
