In late 2002, the health authorities of Mozambique implemented sulphadoxine-pyrimethamine (SP)/amodiaquine (AQ) as first-line treatment against uncomplicated falciparum malaria. In 2004, this has been altered to SP/artesunate in line with WHO recommendations of using Artemisinin Combination Therapies (AC...
Pyrimethamine/pharmacology,
Protozoan Proteins/genetics,
Malaria, Falciparum/epidemiology,
d0161330,
d0138120,
Mozambique/epidemiology,
Ligases,
Drug Combinations,
Drug Resistance/genetics,
Ezetimibe, Simvastatin Drug Combination/therapeutic use,
Pyrimethamine/supply & distribution,
Pharmaceutical Preparations,
Haplotypes/genetics,
Malaria, Falciparum/therapy,
Malaria, Falciparum/parasitology,
Plasmodium falciparum/radiation effects,
Plasmodium falciparum/isolation & purification,
Protozoan Proteins/standards,
Sulfadoxine/pharmacology
Bassat, quique;
Guinovart, caterina;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel 2,;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Characterization of severe malaria cases on arrival to hospital may lead to early recognition and improved management. Minimum community based-incidence rates (MCBIRs) complement hospital data, describing the malaria burden in the community. Methods: A retrospective analysis of all admitted m...
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/mortality,
Malaria, Falciparum/physiopathology,
Malaria, Falciparum/therapy,
Multivariate Analysis,
Plasmodium falciparum/isolation & purification,
Mozambique/epidemiology,
Logistic Models,
Risk Factors,
Seasons,
Hospitalization
Guinovart, caterina;
Bassat, quique;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Menéndez, clara;
Alonso, pedro L.
Background: Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation.
Methods: Retrospective analysis of data collected through the Manhiça morbidit...
Malaria, Falciparum/diagnosis,
Plasmodium falciparum/isolation & purification,
Rural Health Services/statistics & numerical data,
Malaria, Falciparum/therapy,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Ambulatory Care Information Systems/statistics & numerical data,
Risk Factors,
Mozambique/epidemiology
Os traumas resultantes dos acidentes de viação são reconhecidos
mundialmente como um problema importante de saúde pública, atingindo milhares de
pessoas de vários estratos sócio-económicos sem distinção de género ou grupo etário. Em
Moçambique, como em muitos países em desenvolvimento, os t...
A malária é de longe a doença parasitária mais importante em Moçambique, constituindo um grave problema de saúde pública no País. Apesar de se considerar que um diagnóstico atempado e um tratamento correcto são os elementos básicos para um programa de controlo da malária bem sucedido, nas úl...
Malaria/epidemiology,
Plasmodium falciparum/parasitology,
d0006550,
Antimalarials/administration & dosage,
Malaria/prevention & control,
Malaria/diagnosis,
Amodiaquine/administration & dosage,
Chloroquine/administration & dosage,
Patients/statistics & numerical data,
Mozambique/epidemiology,
Sulfadoxine/supply & distribution,
Malaria/mortality
Sacarlal, Jahit;
Aponte, John J;
Aide, Pedro;
Mandomando, Inácio;
Bassat, Quique;
Guinovart, Caterina;
Leach, Amanda;
Milman, Jessica;
Macete, Eusebio;
Espasa, Mateu;
Ofori-Anyinam, Opokua;
Thonnard, Joelle;
Corachan, Sabine;
Dubois, Marie-Claude;
Lievens, Marc;
Dubovsky, Filip;
Ballou, W Ripley;
Cohen, Joe;
Alonso, Pedro L.
RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on the Plasmodium falciparum circumsporozoite surface antigen and is currently the most advanced malaria vaccine candidate in development. A proof of concept phase IIb trial of the RTS,S/AS02A in Mozambican children aged 1-4 years determined a vac...
Malaria Vaccines/adverse effects,
Malaria, Falciparum/prevention & control,
Mozambique/epidemiology,
Child, Preschool,
Double-Blind Method,
Malaria Vaccines/administration & dosage,
Malaria, Falciparum/immunology,
Malaria, Falciparum/epidemiology
Mandomando, inácio;
Espasa, mateu;
Vallès, xavier;
Sigaúque, betuel;
Sanz, sergi;
Sacarlal, jahit;
Macete, eusébio;
Abacassamo, fátima;
Ruiz, joaquim;
Gascon, joaquim;
Kotloff, karen L;
Levine, myron.
Rectal swabs were collected from 1354 children <5 years of age with diarrhea attending Manhiça District Hospital and from 227 healthy community controls. Shigellosis incidence was high among children aged 12-47 months (488.4/10(5) child-years at risk). Fever and dysentery were prominent clinical finding...
Diarrhea/epidemiology,
Diarrhea/microbiology,
Dysentery, Bacillary/epidemiology,
Dysentery, Bacillary/microbiology,
Dysentery, Bacillary/physiopathology,
Shigella/classification,
Shigella/isolation & purification,
Mozambique/epidemiology
Macete, E;
Aponte, J. J;
Guinovart, C;
Sacarlal, J;
Ofori-Anyinam, O;
Mandomando, I;
Espasa, M;
Bevilacqua, C;
Leach, A;
Dubois, M C;
Heppner, D G;
Tello, L;
Milman, J;
Cohen, J;
Dubovsky, F;
Tornieporth, N;
Thompson, R;
Alonso, P. L.
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...
Sharp, brian l;
Kleinschmidt, immo;
Streat, elisabeth;
Maharaj, rajendra;
Barnes, karen i;
Durrheim, david n;
Ridl, frances c;
Morris, natasha;
Seocharan, ishen;
Kunene, simon;
Grange, jacobus j p la;
Mthembu, jotham d;
Maartens, francois;
Martin, carrin l;
Barreto, avertino.
International Cooperation,
Insect Vectors,
Eswatini/epidemiology,
Child, Preschool,
Antimalarials/therapeutic use,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Mosquito Control/methods,
Mozambique/epidemiology,
Plasmodium falciparum/isolation & purification,
Prevalence,
South Africa/epidemiology,
Time Factors
Em 1997, data do último censo, a população moçambicana era em número de 16.099.246 habitantes. Segundo as estimativas do Instituto Nacional de Estatística em Moçambique (INE) referente a 2005, a população moçambicana é de 19.420.036 habitantes. Moçambique situa-se na faixa sul-oriental do Con...
