Background: The optimum age for measles vaccination varies from country to country and thus
a standardized vaccination schedule is controversial. While the increase in measles vaccination
coverage has produced significant changes in the epidemiology of infection, vaccination schedules
have not been adjus...
In late 2002, the health authorities of Mozambique implemented sulphadoxine-pyrimethamine (SP)/amodiaquine (AQ) as first-line treatment against uncomplicated falciparum malaria. In 2004, this has been altered to SP/artesunate in line with WHO recommendations of using Artemisinin Combination Therapies (AC...
Pyrimethamine/pharmacology,
Protozoan Proteins/genetics,
Malaria, Falciparum/epidemiology,
d0161330,
d0138120,
Mozambique/epidemiology,
Ligases,
Drug Combinations,
Drug Resistance/genetics,
Ezetimibe, Simvastatin Drug Combination/therapeutic use,
Pyrimethamine/supply & distribution,
Pharmaceutical Preparations,
Haplotypes/genetics,
Malaria, Falciparum/therapy,
Malaria, Falciparum/parasitology,
Plasmodium falciparum/radiation effects,
Plasmodium falciparum/isolation & purification,
Protozoan Proteins/standards,
Sulfadoxine/pharmacology
Mayor, Alfredo;
Serra-Casas, Elisa;
Sanz, Sergi;
Aponte, João J;
Machete, eusebio;
Mandomando, Inácio;
Puyol, Laura;
Berzosa, Pedro;
Dobanã, Carlota;
Aide, pedro;
Sacarlal, jahit;
Benito, Agustín;
Alonso, Pedro;
Menendéz, Clara.
Background. Intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP) is a po tential malaria control strategy. There is concern about the impact that increasing in vivo resistance to SP has on the efficacy of IPTi, as well as about the potential contribution of IPTi to incr...
Bassat, quique;
Guinovart, caterina;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel 2,;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Characterization of severe malaria cases on arrival to hospital may lead to early recognition and improved management. Minimum community based-incidence rates (MCBIRs) complement hospital data, describing the malaria burden in the community. Methods: A retrospective analysis of all admitted m...
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/mortality,
Malaria, Falciparum/physiopathology,
Malaria, Falciparum/therapy,
Multivariate Analysis,
Plasmodium falciparum/isolation & purification,
Mozambique/epidemiology,
Logistic Models,
Risk Factors,
Seasons,
Hospitalization
Guinovart, caterina;
Bassat, quique;
Sigaúque, betuel;
Aide, pedro;
Sacarlal, jahit;
Nhampossa, tacilta;
Bardají, azucena;
Nhacolo, ariel;
Macete, eusébio;
Mandomando, inácio;
Aponte, john J;
Menéndez, clara;
Alonso, pedro L.
Background: Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation.
Methods: Retrospective analysis of data collected through the Manhiça morbidit...
Malaria, Falciparum/diagnosis,
Plasmodium falciparum/isolation & purification,
Rural Health Services/statistics & numerical data,
Malaria, Falciparum/therapy,
Malaria, Falciparum/epidemiology,
Malaria, Falciparum/prevention & control,
Ambulatory Care Information Systems/statistics & numerical data,
Risk Factors,
Mozambique/epidemiology
Os traumas resultantes dos acidentes de viação são reconhecidos
mundialmente como um problema importante de saúde pública, atingindo milhares de
pessoas de vários estratos sócio-económicos sem distinção de género ou grupo etário. Em
Moçambique, como em muitos países em desenvolvimento, os t...
A malária é de longe a doença parasitária mais importante em Moçambique, constituindo um grave problema de saúde pública no País. Apesar de se considerar que um diagnóstico atempado e um tratamento correcto são os elementos básicos para um programa de controlo da malária bem sucedido, nas úl...
Malaria/epidemiology,
Plasmodium falciparum/parasitology,
d0006550,
Antimalarials/administration & dosage,
Malaria/prevention & control,
Malaria/diagnosis,
Amodiaquine/administration & dosage,
Chloroquine/administration & dosage,
Patients/statistics & numerical data,
Mozambique/epidemiology,
Sulfadoxine/supply & distribution,
Malaria/mortality
Sacarlal, Jahit;
Aponte, John J;
Aide, Pedro;
Mandomando, Inácio;
Bassat, Quique;
Guinovart, Caterina;
Leach, Amanda;
Milman, Jessica;
Macete, Eusebio;
Espasa, Mateu;
Ofori-Anyinam, Opokua;
Thonnard, Joelle;
Corachan, Sabine;
Dubois, Marie-Claude;
Lievens, Marc;
Dubovsky, Filip;
Ballou, W Ripley;
Cohen, Joe;
Alonso, Pedro L.
RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on the Plasmodium falciparum circumsporozoite surface antigen and is currently the most advanced malaria vaccine candidate in development. A proof of concept phase IIb trial of the RTS,S/AS02A in Mozambican children aged 1-4 years determined a vac...
Malaria Vaccines/adverse effects,
Malaria, Falciparum/prevention & control,
Mozambique/epidemiology,
Child, Preschool,
Double-Blind Method,
Malaria Vaccines/administration & dosage,
Malaria, Falciparum/immunology,
Malaria, Falciparum/epidemiology
Mandomando, inácio;
Espasa, mateu;
Vallès, xavier;
Sigaúque, betuel;
Sanz, sergi;
Sacarlal, jahit;
Macete, eusébio;
Abacassamo, fátima;
Ruiz, joaquim;
Gascon, joaquim;
Kotloff, karen L;
Levine, myron.
Rectal swabs were collected from 1354 children <5 years of age with diarrhea attending Manhiça District Hospital and from 227 healthy community controls. Shigellosis incidence was high among children aged 12-47 months (488.4/10(5) child-years at risk). Fever and dysentery were prominent clinical finding...
Diarrhea/epidemiology,
Diarrhea/microbiology,
Dysentery, Bacillary/epidemiology,
Dysentery, Bacillary/microbiology,
Dysentery, Bacillary/physiopathology,
Shigella/classification,
Shigella/isolation & purification,
Mozambique/epidemiology
Marijon, Eloi;
Ou, Phalla;
Celermajer, David S;
Ferreira, Beatriz;
Mocumbi, Ana Olga;
Jani, Dinesh;
Paquet, Christophe;
Jacob, Sophie;
Sidi, Daniel;
Jouven, Xavier.
Background: Epidemiologic studies of the prevalence of rheumatic heart disease have used clinical screening with echocardiographic confirmation of suspected cases. We hypothesized that echocardiographic screening of all surveyed children would show a significantly higher prevalence of rheumatic heart dis...
