Total: 1720

B-cell immunity and vaccine induced antibody protection reveal the inefficacy of current vaccination schedule in infants with perinatal HIV-infection in Mozambique, Africa

EBioMedicine; 93 (104666), 2023
Despite antiretroviral treatment (ART), immune dysfunction persists in children with perinatal HIV infection (HEI). Here we investigated the impact of HIV status on maternal antibody (Ab) passage, long-term vaccine induced immunity and B-cell maturation. Methods: 46 HIV Exposed Uninfected (HEU), 43 HEI,...

Inquérito Nacional sobre o Impacto do HIV e SIDA em Moçambique (INSIDA 2021)
National Survey on the Impact of HIV and AIDS in Mozambique (INSIDA 2021

O Inquérito sobre o Impacto do HIV e SIDA em Moçambique (INSIDA 2021) foi um inquérito nacional baseado nos agregados familiares, conduzido entre Abril de 2021 e Fevereiro de 2022, visando medir o impacto da resposta nacional ao HIV. O INSIDA 2021 ofereceu aconselhamento e testagem de HIV com entrega ...

Atitude dos homens usuários dos serviços de saúde, no centro de saúde do chamanculo, em relação ao planeamento familiar
Attitude of male users of health services at the chamanculo health center towards family planning family planning

Introdução: As políticas em relação ao planeamento familiar, vem desde muito tempo se dedicando principalmente às mulheres, mesmo sabendo-se que os homens têm um papel importante a desempenhar neste sentido, podendo suas atitudes interferir, positiva ou negativamente, na decisão das suas companhe...

How point-of-care testing could drive innovation in global health

N. Engl. j. med; 368 (24), 2023
The investment in health services in low- and middle-income countries has increased substantially in recent years.1 Such investment has been led by unprecedented efforts to combat major diseases, enabled by the availability of lower-cost and effective drug regimens for treatment and prophylaxis, along wi...

Increased peripartum mortality associated with maternal subclinical malaria in Mozambique

Malar. j. (Online); 22 (182), 2023
Background: Plasmodium falciparum infection in pregnant women in sub-Saharan Africa is often asymptomatic. As these forms of malaria are often submicroscopic and difficult to diagnose by conventional methods (microscopy and/or rapid diagnostic test), diagnosis requires the use of molecular techniques suc...

Associations of WHO/UNICEF Joint Monitoring Program (JMP) Water, Sanitation and Hygiene (WASH) Service Ladder service levels and sociodemographic factors with diarrhoeal disease among children under 5 years in Bishoftu town, Ethiopia: a cross-sectional study

BMJ Open; 13 (1296), 2023
Diarrhoea among children under 5years is a central public health issue worldwide.5 It causes more than 1.7billion cases and kills 525 000 children under 5years old each year, making it the world’s second leading cause of mortality among children under 5years. 6 Globally, diarrhoeal disease accounts for...

Targeted and whole-genome sequencing reveal a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique

Commun. biolog; 6 (1), 2023
Mozambique is one of the four African countries which account for over half of all malaria deaths worldwide, yet little is known about the parasite genetic structure in that country. We performed P. falciparum amplicon and whole genome sequencing on 2251 malaria-infected blood samples collected in 2015 a...

Measuring the burden of SARS-CoV-2 infection among persons living with HIV and healthcare workers and its impact on service delivery in Mozambique: protocol of a prospective cohort study

BMJ Open; 13 (6), 2023
Introduction: As COVID-19 continues to spread globally and within Mozambique, its impact among immunosuppressed persons, specifically persons living with HIV (PLHIV), and on the health system is unknown in the country. The 'COVid and hIV' (COVIV) study aims to investigate: (1) the seroprevalence and sero...

Long-term impacts of an urban sanitation intervention on enteric pathogens in children in Maputo city, Mozambique: study protocol for a cross-sectional follow-up to the Maputo Sanitation (MapSan) trial 5 years postintervention

BMJ Open; 13 (6), 2023
Introduction We previously assessed the effect of an onsite sanitation intervention in informal neighbourhoods of urban Maputo, Mozambique on enteric pathogen detection in children after 2 years of follow-up (Maputo Sanitation (MapSan) trial, ClinicalTrials.gov: NCT02362932). We found significant reducti...

Positive attitudes toward adoption of a multi-component intervention strategy aimed at improving HIV outcomes among adolescents and young people in Nampula, Mozambique: perspectives of HIV care providers

Background: Service providers' attitudes toward interventions are essential for adopting and implementing novel interventions into healthcare settings, but evidence of evaluations in the HIV context is still limited. This study is part of the CombinADO cluster randomized trial (ClinicalTrials.gov NCT0493...