Results: 186

VAR2CSA Serology to Detect Plasmodium falciparum Transmission Patterns in Pregnancy

Emerg. infect. dis; 25 (10), 2019
Pregnant women constitute a promising sentinel group for continuous monitoring of malaria transmission. To identify antibody signatures of recent Plasmodium falciparum exposure during pregnancy, we dissected IgG responses against VAR2CSA, the parasite antigen that mediates placental sequestration. We use...

Differential expression of var subgroups and PfSir2a genes in afebrile Plasmodium falciparum malaria: a matched case-control study

Malar. j. (Online); 18 (1), 2019
Background: Poor knowledge on the afebrile Plasmodium falciparum biology limits elimination approaches to target asymptomatic malaria. Therefore, the association of parasite factors involved in cytoadhesion, parasite multiplication and gametocyte maturation with afebrile malaria was assessed. Methods: Pl...

A Balanced Proinflammatory and Regulatory Cytokine Signature in Young African Children Is Associated With Lower Risk of Clinical Malaria

Clin. infect. dis; 69 (Sep.2019), 2019
The effect of timing of exposure to first Plasmodium falciparum infections during early childhood on the induction of innate and adaptive cytokine responses and their contribution to the development of clinical malaria immunity is not well established. As part of a double-blind, randomized, placebo-contr...

Examining community perceptions of malaria to inform elimination efforts in Southern Mozambique: a qualitative study

Malar. j. (Online); 18 (232), 2019
Background: In a background of renewed calls for malaria eradication, several endemic countries in sub-Saharan Africa are contemplating malaria elimination nationally or sub-nationally. In Mozambique, a strategy to eliminate malaria in the south is underway in the context of low endemicity levels and cro...

Differential patterns of disease and injury in Mozambique: New perspectives from a pragmatic, multicenter, surveillance study of 7809 emergency presentations

PLOS ONE; 14 (7), 2019
There is a paucity of primary data to understand the overall pattern of disease and injuries as well as related health-service utilization in resource-poor countries in Africa. To generate reliable and robust data describing the pattern of emergency presentations attributable to communicable disease (CD)...

Setting the scene and generating evidence for malaria elimination in Southern Mozambique

Malar. j. (Online); 18 (190), 2019
Mozambique has historically been one of the countries with the highest malaria burden in the world. Starting in the 1960s, malaria control efforts were intensified in the southern region of the country, especially in Maputo city and Maputo province, to aid regional initiatives aimed to eliminate malaria ...

Inquerito nacional sobre indicadores de malaria (IIM) 2018

Instituto Nacional de Saúde (INS) em colaboração com o Programa Nacional de Controlo da Malária (PNCM) e o Instituto Nacional de Estatística (INE), realizou o Inquérito Nacional de Indicadores de Malária (IIM 2018). O IIM 2018 foi um inquérito de base populacional concebido para obter estimativas...

Escalation of Pyrethroid Resistance in the Malaria Vector Anopheles funestus Induces a Loss of Efficacy of Piperonyl Butoxide–Based Insecticide-Treated Nets in Mozambique

Insecticide resistance poses a serious threat to insecticide-based interventions in Africa. There is a fear that resistance escalation could jeopardize malaria control efforts. Monitoring of cases of aggravation of resistance intensity and its impact on the efficacy of control tools is crucial to predict...

Malaria case management commodity supply and use by community health workers in Mozambique, 2017

Malar. j. (Online); 18 (47), 2019
Community health workers (CHWs) provide preventive care and integrated community case management (iCCM) to people with low healthcare access worldwide. CHW programmes have helped reduce mortality in myriad countries, but little data on malaria supply chain management has been shared. This project evaluat...

Incidência da malária na região centro de moçambique: determinantes naturais e condicionantes sociais – uma perspectiva geográfica

A malária é uma doença infecciosa causada pelo protozoário unicelular do gênero Plasmodium. É uma patologia que continua a causar significante morbimortalidade nas áreas onde é prevalente, sobretudo em Moçambique, com ênfase para a Região Centro. Geralmente, a doença tem afetado de forma desp...