Alonso, Selena;
Vudal, Marta;
Olalla, Gemma Ruiz;
Gonzelez, Raquel;
Manaca, M Nelia;
Jairoce, Chenjerai;
Balcells, Reyes;
Vala, Anifa;
Ruperez, María;
Soro, Laura Fuente;
Cova, Marta;
Angov, Evelina;
Nhacolo, Arsenio;
Sevene, Esperança;
Aponte, John J;
Macete, Eusebio;
Dobano, Carlota;
Moncunil, Gemma.
Transplacental transfer of antibodies is essential for conferring protection in newborns against infectious diseases. We assessed the impact of different factors, including gestational age and maternal infections such as HIV and malaria, on the efficiency of cord blood levels and placental transfer of Ig...
Antibodies/immunology,
Antigens/immunology,
Antiretroviral Therapy, Highly Active,
Fetal Blood/immunology,
HIV Infections/therapy,
HIV Infections/epidemiology,
HIV Infections/immunology,
HIV Infections/virology,
Immunity, Maternally-Acquired,
Immunoglobulin G/immunology,
Maternal-Fetal Exchange/immunology,
Placenta/metabolism,
Pregnancy,
Carrier Proteins,
Sex Factors,
Vaccines/immunology
Results from two recently established population-based registries in Mozambique are reported: Beira in the central region (2014-2017) and Maputo, the capital city, in the South (2015-2017). The results are compared to those from Maputo (Lourenço Marques at the time) in 1956-1960 (appearing Cancer Incide...
Chissumbam, raquel, matavele;
Namalango, eduardo;
Maphossa, vânia;
Macicame, ivalda;
Bhatt, nilesh;
Polyak, christina;
Michael, nelson;
Jani, ilesh, v;
Kestens, luc.
Background: The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation. Regulatory T cells (Tregs) have the potential to control systemic immune activation but also to suppress antigen specific T and B cell res...
CD4-Positive T-Lymphocytes/cytology,
Flow Cytometry,
Forkhead Transcription Factors/immunology,
HIV Infections/immunology,
HIV-1/immunology,
Virus Replication,
Viral Load,
CD4-Positive T-Lymphocytes/virology,
CD4-Positive T-Lymphocytes/immunology,
HIV Infections/virology,
Ikaros Transcription Factor/genetics,
Minor Lymphocyte Stimulatory Antigens,
T-Lymphocytes, Regulatory/immunology,
T-Lymphocytes, Regulatory/virology,
Viral Replication Compartments/immunology,
Mozambique
Voronin, yegor;
Jani, ilesh;
Graham, barney, s;
Cunningham, coleen, k;
Mofenson, lynne, m;
Musoke, philippa, m;
Permar, sallie, r;
Scarlatti, gabriella.
Globally, 150,000 new paediatric human immunodeficiency virus type 1 (HIV-1) infections occurred in 2015. There remain complex challenges to the global elimination of paediatric HIV-1 infection. Thus, for the global community to achieve elimination of new paediatric HIV-1 infections, innovative approache...
HIV-1,
HIV-1/immunology,
AIDS Vaccines/administration & dosage,
HIV Antibodies,
AIDS Vaccines/immunology,
HIV Infections,
Antibodies, Neutralizing/immunology,
HIV Antibodies/immunology,
HIV Infections/immunology,
HIV Infections/prevention & control,
Infections/virology,
Infectious Disease Transmission, Vertical/prevention & control
Meggi, Bindiya;
Bollinger, Timothy;
Mabunda, Nédio;
Vubil, Adolfo;
Tobaiwa, Ocean;
Quevedo, Jorge I;
Loquiha, Osvaldo;
Vojnov, Lara;
Peter, Trevor F;
Jani, Ilesh V.
The long delay in returning test results during early infant diagnosis of HIV (EID) often
causes loss-to-follow-up prior to antiretroviral treatment (ART) initiation in resource-limited
settings. A point-of-care (POC) test may help overcome these challenges. We evaluated
the performance of the LYNX p24 A...
Anti-HIV Agents/therapeutic use,
Early Diagnosis,
HIV Infections/diagnosis,
HIV Infections/therapy,
HIV Infections/epidemiology,
HIV Infections/immunology,
Point-of-Care Testing/standards,
Reproducibility of Results,
Mozambique/epidemiology,
Sensitivity and Specificity,
HIV-1/immunology
Background In resource-limited countries, CD4 T-cell (CD4) testing continues to be used for determining antiretroviral therapy (ART) initiation eligibility and opportunistic infection monitoring. To support expanded access to CD4 testing, simple and robust technologies are necessary. We conducted this st...
Sensitivity and Specificity,
Reproducibility of Results,
Mozambique,
Middle Aged,
Men,
Humans,
HIV Seropositivity,
Allergy and Immunology,
Child, Preschool,
CD4 Lymphocyte Count/instrumentation,
HIV Infections/immunology
Moro, Laura;
Bardaji, Azucena;
Nhampossa, Tacilta;
Mandomando, Inácio;
Serra-Casas, Elisa;
Sigauque, Betuel;
Cistero, Pau;
Chauhan, Virander S;
Chitnis, Chetan E;
Ordi, Jaume;
Dobaño, Carlota;
Alonso, Pedro L;
Menendez, Clara;
Mayor, Alfredo.
Background. Malaria and human immunodeficiency virus (HIV) during pregnancy affect the transplacental transfer of antibodies against several pathogens from mother to fetus, although their effect over antimalarial antibodies remains unclear.
Methods. Total immunoglobulin G (IgG), IgM and IgG subtypes aga...
Malaria, Falciparum/immunology,
Pregnancy Complications, Parasitic/virology,
Pregnancy Complications, Parasitic/immunology,
Antibodies, Protozoan/blood,
Pregnancy Complications, Parasitic/microbiology,
Maternal-Fetal Exchange,
Infant, Newborn,
HIV Infections/immunology,
Mozambique/epidemiology,
Fetal Blood/immunology,
Coinfection/immunology,
Coinfection/virology,
Coinfection/parasitology
As células T CD4 reguladoras (Tregs) são críticas na manutenção da homeostase do sistema imunológico. Alterações quantitativas ou fenotípicas e comprometimento funcional de Tregs têm sido associados ao desenvolvimento de patologias incluindo as do sistema nervoso central. Indivíduos com coinfe...
CD4 Antigens/metabolism,
HIV Infections/immunology,
Coinfection/immunology,
Coinfection/virology,
Forkhead Transcription Factors/metabolism,
HIV Infections/virology,
HIV-1/immunology,
HLA-DR Antigens/immunology,
HTLV-I Infections/immunology,
HTLV-I Infections/virology,
Interleukin-2 Receptor alpha Subunit/metabolism,
Nervous System Diseases/immunology,
Nervous System Diseases/pathology,
T-Lymphocytes, Regulatory/immunology,
Mozambique/epidemiology,
HLA-A Antigens/genetics,
HLA-B Antigens/genetics,
HLA-DR Antigens
Elul, batya;
Lahuerta, maria;
Abacassamo, Fatima;
Lamb, matthew, r;
Ahoua, laurence;
McNairy, margaret, l;
Tomo, Maria;
Horowitz, deborah;
Sutton, roberta;
Mussa, antonio;
Gurr, danielle;
Jani, ilesh, v.
Background: Despite the extraordinary scale up of HIV prevention, care and treatment services in sub-Saharan Africa (SSA) over the past decade, the overall effectiveness of HIV programs has been significantly hindered by high levels of attrition across the HIV care continuum. Data from “real-life” se...
Anti-HIV Agents/therapeutic use,
HIV Infections/diagnosis,
CD4 Lymphocyte Count,
Mozambique,
Clinical Protocols,
Anti-HIV Agents,
HIV Infections/therapy,
HIV Infections/immunology,
Patient Compliance,
Catchment Area, Health
Bergeron, michèle;
Daneau, géraldine;
Ding, tao;
Sitoe, Nádia;
Westerman, larry, e;
Stokx, jocelijn;
Jani, ilesh, v;
Coetzee, lindi, m;
Scott, lesley;
Weggheleire, anja de;
Boel, Luc;
Stevens, wendy, s;
Glencross, deborah;
Peter, trevor, f.
Introduction: Point-of-care (POC) CD4 testing can improve access to treatment by enabling decentralization and reducing patient loss-to-follow-up. As new POC CD4 technologies become available, their performance should be assessed before widespread deployment. This study reports the findings of five indep...
