Gray, Glenda E;
Mngadi, Kathryn;
Lavreys, Ludo;
Nijs, Steven;
Gilbert, Peter B;
Hural, John;
Hyrien, Ollivier;
Juraska, Michal;
Luedtke, Alex;
Mann, Philipp;
McElrath, M Juliana;
Odhiambo, Jackline A;
Stieh, Daniel J;
Duijn, Janine van;
Takalani, Azwidihwi N;
Willems, Wouter;
Tapley, Asa;
Tomaras, Georgia D;
Hoof, Johan Van;
Schuitemaker, Hanneke;
Swann, Edith;
Barouch, Dan H;
Kublin, James G;
Corey, Lawrence;
Pau, Maria G;
Buchbinder, Susan;
Tomaka, Frank.
Background: HIV type 1 (HIV-1) remains a global health concern, with the greatest burden in sub-Saharan Africa. Despite 40 years of research, no vaccine candidate has shown durable and protective efficacy against HIV-1 acquisition. Although pre-exposure prophylaxis in groups with high vulnerability can b...
Augusto, Ângelo do Rosário;
Nnaemeka, Nnaemeka C;
Kohatsu, Luciana;
Sousa, Leonardo de;
Maueia, Cremildo;
Hara, Cristina;
Mula, Flora;
Cuamba, Gércio;
Chelene, Imelda;
Langa, Zainabo;
Lohman, Nathaniel;
Faife, Flávio;
Giles, Denise;
Sabonete, Acácio José;
Gudo, Eduardo Samo;
Jani, Ilesh;
Parekh, Bharat S.
Effective implementation of the national Human Immunodeficiency Virus (HIV) programs require monitoring the HIV epidemic trends to identify programmatic successes, challenges, and needed improvements. HIV prevalence estimates, defined as the percentage of a population affected by HIV, are calculated by t...
Chissumba, Raquel Matavele;
Luciano, Abílio;
Namalango, Eduardo;
Bauer, Asli;
Bhatt, Nilesh;
Wharen, Britta;
Nilsson, Charlotta;
Geldmacher, Christof;
Scarlatti, Gabriella;
Jani, Ilesh;
Kastens, Luc.
Little is known about regulatory CD4 T cells (Tregs) in the context of HIV vaccines. Tregs can be differentiated into resting (FoxP3+CD45RA+ - rTregs), activated (FoxP3HighCD45RA- - aTregs) and memory (FoxP3LowCD45RA- - mTregs). Tregs, as CD4 T cells, are also frequent targets for HIV infection. We studi...
AIDS Vaccines/immunology,
Antibodies, Neutralizing/immunology,
CD4 Lymphocyte Count,
Cytokines/biosynthesis,
HIV Antibodies/immunology,
HIV Infections/prevention & control,
HIV Infections/virology,
HIV-1/immunology,
HIV-1/genetics,
Mozambique,
CD8-Positive T-Lymphocytes/immunology,
T-Lymphocytes, Regulatory/metabolism,
Vaccines, DNA/immunology,
Vaccines, DNA/genetics
Chissumbam, raquel, matavele;
Namalango, eduardo;
Maphossa, vânia;
Macicame, ivalda;
Bhatt, nilesh;
Polyak, christina;
Michael, nelson;
Jani, ilesh, v;
Kestens, luc.
Background: The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation. Regulatory T cells (Tregs) have the potential to control systemic immune activation but also to suppress antigen specific T and B cell res...
CD4-Positive T-Lymphocytes/cytology,
Flow Cytometry,
Forkhead Transcription Factors/immunology,
HIV Infections/immunology,
HIV-1/immunology,
Virus Replication,
Viral Load,
CD4-Positive T-Lymphocytes/virology,
CD4-Positive T-Lymphocytes/immunology,
HIV Infections/virology,
Ikaros Transcription Factor/genetics,
Minor Lymphocyte Stimulatory Antigens,
T-Lymphocytes, Regulatory/immunology,
T-Lymphocytes, Regulatory/virology,
Viral Replication Compartments/immunology,
Mozambique
Voronin, yegor;
Jani, ilesh;
Graham, barney, s;
Cunningham, coleen, k;
Mofenson, lynne, m;
Musoke, philippa, m;
Permar, sallie, r;
Scarlatti, gabriella.
Globally, 150,000 new paediatric human immunodeficiency virus type 1 (HIV-1) infections occurred in 2015. There remain complex challenges to the global elimination of paediatric HIV-1 infection. Thus, for the global community to achieve elimination of new paediatric HIV-1 infections, innovative approache...
HIV-1,
HIV-1/immunology,
AIDS Vaccines/administration & dosage,
HIV Antibodies,
AIDS Vaccines/immunology,
HIV Infections,
Antibodies, Neutralizing/immunology,
HIV Antibodies/immunology,
HIV Infections/immunology,
HIV Infections/prevention & control,
Infections/virology,
Infectious Disease Transmission, Vertical/prevention & control
Chang, joy;
Sousa, amina de;
Sabatier, jennifer;
Assane, mariamo;
Zhang, guoqing;
Bila, dulce;
Vaz, paula;
Alfredo, charity;
Cossa, Loide;
Bhatt, Nilesh;
Koumans, emilia, h;
Yang, chunfu;
Rivadeneira, emilia;
Jani, ilesh;
Houston, james, c.
Quantitative plasma viral load (VL) at 1000 copies /mL was recommended as the threshold to confirm antiretroviral therapy (ART) failure by the World Health Organization (WHO). Because of ongoing challenges of using plasma for VL testing in resource-limited settings (RLS), especially for children, this st...
Meggi, Bindiya;
Bollinger, Timothy;
Mabunda, Nédio;
Vubil, Adolfo;
Tobaiwa, Ocean;
Quevedo, Jorge I;
Loquiha, Osvaldo;
Vojnov, Lara;
Peter, Trevor F;
Jani, Ilesh V.
The long delay in returning test results during early infant diagnosis of HIV (EID) often
causes loss-to-follow-up prior to antiretroviral treatment (ART) initiation in resource-limited
settings. A point-of-care (POC) test may help overcome these challenges. We evaluated
the performance of the LYNX p24 A...
Anti-HIV Agents/therapeutic use,
Early Diagnosis,
HIV Infections/diagnosis,
HIV Infections/therapy,
HIV Infections/epidemiology,
HIV Infections/immunology,
Point-of-Care Testing/standards,
Reproducibility of Results,
Mozambique/epidemiology,
Sensitivity and Specificity,
HIV-1/immunology
As células T CD4 reguladoras (Tregs) são críticas na manutenção da homeostase do sistema imunológico. Alterações quantitativas ou fenotípicas e comprometimento funcional de Tregs têm sido associados ao desenvolvimento de patologias incluindo as do sistema nervoso central. Indivíduos com coinfe...
CD4 Antigens/metabolism,
HIV Infections/immunology,
Coinfection/immunology,
Coinfection/virology,
Forkhead Transcription Factors/metabolism,
HIV Infections/virology,
HIV-1/immunology,
HLA-DR Antigens/immunology,
HTLV-I Infections/immunology,
HTLV-I Infections/virology,
Interleukin-2 Receptor alpha Subunit/metabolism,
Nervous System Diseases/immunology,
Nervous System Diseases/pathology,
T-Lymphocytes, Regulatory/immunology,
Mozambique/epidemiology,
HLA-A Antigens/genetics,
HLA-B Antigens/genetics,
HLA-DR Antigens
To determine the prevalence of acute HIV infection (AHI) within the HIV-seronegative adult population presenting with reported fever in a district hospital in southern Mozambique and evaluate clinical, immunological and virological parameters of AHI.
Design:
This is a prospective observational study.
...
HIV Infections/epidemiology,
Mozambique,
Outpatients,
HIV Infections/diagnosis,
d0084030,
HIV Seronegativity,
HIV-1/immunology,
Malaria, Falciparum/diagnosis,
Malaria, Falciparum/epidemiology,
Plasmodium falciparum/isolation & purification
