CD4+CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor
CD4(+)CD25(High) Treg cells in HIV/HTLV co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor
BMC immunol. (Online); 16 (52), 2015
As células T CD4 reguladoras (Tregs) são críticas na manutenção da homeostase do sistema imunológico. Alterações quantitativas ou fenotípicas e comprometimento funcional de Tregs têm sido associados ao desenvolvimento de patologias incluindo as do sistema nervoso central. Indivíduos com coinfe...
CD4 Antigens/metabolism, HIV Infections/immunology, Coinfection/immunology, Coinfection/virology, Forkhead Transcription Factors/metabolism, HIV Infections/virology, HIV-1/immunology, HLA-DR Antigens/immunology, HTLV-I Infections/immunology, HTLV-I Infections/virology, Interleukin-2 Receptor alpha Subunit/metabolism, Nervous System Diseases/immunology, Nervous System Diseases/pathology, T-Lymphocytes, Regulatory/immunology, Mozambique/epidemiology, HLA-A Antigens/genetics, HLA-B Antigens/genetics, HLA-DR Antigens