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Helios + Regulatory T cell frequencies are correlated with control of viral replication and recovery of absolute CD4 T cells counts in early HIV-1 infection

Chissumbam, raquel, matavele; Namalango, eduardo; Maphossa, vânia; Macicame, ivalda; Bhatt, nilesh; Polyak, christina; Michael, nelson; Jani, ilesh, v; Kestens, luc.
BMC immunol. (Online); 18 (1), 2017
Background: The acute phase of HIV infection is characterized by massive depletion of CD4 T cells, high viral plasma levels and pronounced systemic immune activation. Regulatory T cells (Tregs) have the potential to control systemic immune activation but also to suppress antigen specific T and B cell res...
CD4-Positive T-Lymphocytes/cytology, Flow Cytometry, Forkhead Transcription Factors/immunology, HIV Infections/immunology, HIV-1/immunology, Virus Replication, Viral Load, CD4-Positive T-Lymphocytes/virology, CD4-Positive T-Lymphocytes/immunology, HIV Infections/virology, Ikaros Transcription Factor/genetics, Minor Lymphocyte Stimulatory Antigens, T-Lymphocytes, Regulatory/immunology, T-Lymphocytes, Regulatory/virology, Viral Replication Compartments/immunology, Mozambique
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CD4+CD25High Treg cells in HIV/HTLV Co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor
CD4(+)CD25(High) Treg cells in HIV/HTLV co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor

Chissumba, Raquel; Silva-Barbosa, Suse Dayse; Augusto, Ângelo; Mauéia, Cremildo; Mabunda, Nédio; Gudo, Eduardo Samo; Bhatt, Nilesh; Jani, Ilesh; Savimo, Wilson.
BMC immunol. (Online); 16 (52), 2015
As células T CD4 reguladoras (Tregs) são críticas na manutenção da homeostase do sistema imunológico. Alterações quantitativas ou fenotípicas e comprometimento funcional de Tregs têm sido associados ao desenvolvimento de patologias incluindo as do sistema nervoso central. Indivíduos com coinfe...
CD4 Antigens/metabolism, HIV Infections/immunology, Coinfection/immunology, Coinfection/virology, Forkhead Transcription Factors/metabolism, HIV Infections/virology, HIV-1/immunology, HLA-DR Antigens/immunology, HTLV-I Infections/immunology, HTLV-I Infections/virology, Interleukin-2 Receptor alpha Subunit/metabolism, Nervous System Diseases/immunology, Nervous System Diseases/pathology, T-Lymphocytes, Regulatory/immunology, Mozambique/epidemiology, HLA-A Antigens/genetics, HLA-B Antigens/genetics, HLA-DR Antigens
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