Nhama , Abel;
Nhamússua, Lídia;
Macete, Eusébio;
Bassat, Quique;
Salvador, Crizolgo;
Enosse, Sónia;
Candrinho, Baltazar;
Carvalho, Eva;
Nhacolo, Arsénio;
Chidimatembue, Arlindo;
Saifodine , Abuchahama;
Zulliger, Rose;
Lucchi, Naomi;
Svigel, Samaly S;
Moriarty , Leah F;
Halsey, Eric S;
Mayor, Alfredo;
Aide , Pedro.
Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether-lumefantrine (AL) and amodiaquine-artesunate (AS-AQ) as the first choice. To assess efficacy of currently used ACT, an in vivo therapeutic efficacy...
Amodiaquina,
Antimaláricos/uso terapêutico,
Combinação de Medicamentos,
Antimaláricos/normas,
Parasitemia,
Resultado do Tratamento,
d0082880,
Combinação Arteméter e Lumefantrina/farmacologia,
Combinação Arteméter e Lumefantrina/uso terapêutico,
Malária Falciparum/terapia,
Parasitemia/tratamento farmacológico,
Moçambique/epidemiologia
Galatas, beatriz;
Soler, helena martí;
Nhamussua, lidia;
Cisteró, pau;
Assessor, pedro;
Menéndez, clara;
Saute, francisco;
Rabinovich, regina;
Alonso, pedro L;
Prefeito, alfredo;
Bassat, quique.
Background. Afebrile Plasmodium falciparum infections usually remain undetected and untreated in the community and could potentially contribute to sustaining local malaria transmission in areas aiming for malaria elimination. Methods. Thirty-two men with afebrile P. falciparum infections detected with ra...
A primary concern for the RTS,S malaria vaccine candidate is duration of protection. The ongoing Phase III trial reported evidence of waning efficacy within the first year following vaccination. Multiple Phase IIb trials demonstrated early waning of efficacy. The longest duration of protection for RTS,S ...
Background: Co-infection with falciparum malaria and HIV-1 increases the severity and mortality of both infections in unstable malaria-transmission areas. In contrast, in stable transmission areas, HIV co-infection increases the severity of both infections but has not been found to influence malaria mort...
Plasmodium falciparum/isolamento & purificação,
Coinfecção/complicações,
Coinfecção/epidemiologia,
Coinfecção/mortalidade,
Infecções por HIV/complicações,
Infecções por HIV/epidemiologia,
Infecções por HIV/mortalidade,
HIV-1/isolamento & purificação,
Malária Falciparum/complicações,
Malária Falciparum/epidemiologia,
Malária Falciparum/mortalidade,
Parasitemia/complicações,
Parasitemia/epidemiologia,
Parasitemia/mortalidade,
Fatores de Risco,
Estudos Prospectivos,
Moçambique/epidemiologia
Background: Asymptomatic Plasmodium falciparum parasitemia (APFP) has been reported to be highly prevalent in Sub-Saharan Africa, a region heavily burdened by malaria, yet, the impact of APFP on the immunological reference values have not yet been established. This study was aimed at i) determine the pre...
Background: Plasmodium falciparum and HIV-1 infection cause substantial morbidity and mortality in sub-Saharan Africa. Increasing evidence suggests these two pathogens interact negatively when infecting the same individual.
Methods: A cross-sectional study among HIV-1 infected and uninfected populations...
Mayor, alfredo;
Casas, elisa serra;
Bardají, azucena;
Sanz, sergi;
Puyol, laura;
Cisteró, pau;
Sigauque, betuel;
Mandomando, inacio;
Aponte, john J;
Alonso, pedro L;
Menéndez, clara.
Background: Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal.
Methods: The presence of Plasmodium falciparum was assessed by real-...
Malária Falciparum/epidemiologia,
Proteína 1 de Superfície de Merozoito,
Plasmodium falciparum,
Proteínas de Protozoários,
Pirimetamina,
Malária Falciparum/terapia,
Malária Falciparum/parasitologia,
Parasitemia/terapia,
Parasitemia/epidemiologia,
Plasmodium falciparum/efeitos dos fármacos,
Plasmodium falciparum/genética,
Plasmodium falciparum/isolamento & purificação,
Reação em Cadeia da Polimerase,
Complicações Parasitárias na Gravidez/terapia,
Complicações Parasitárias na Gravidez/epidemiologia,
Complicações Parasitárias na Gravidez/parasitologia
Bardají, azucena;
Sigauque, betuel;
Bruni, mlaia;
Romagosa, cleofé;
Sanz, sergi;
Mabunda, samuel;
Mandomando, inacio;
Aponte, john;
Sevene, esperança;
Alonso, pedro L;
Menéndez, clara.
Background: There is a widespread notion, based on limited information, that in areas of stable malaria transmission most pregnant women with Plasmodium falciparum infection are asymptomatic. This study aim to characterize the clinical presentation of malaria in African pregnant women and to evaluate the...
Malaria infection during pregnancy (MiP) is heterogeneously distributed even in malaria-endemic countries. Program planners require data to facilitate identification of highest-priority populations for MiP control. Using data from two cross-sectional studies of 5,528 pregnant women in 8 neighboring sites...
Para caracterizar as alterações histológicas nas placentas da malária e sua relação com a paridade e parasitemias maternas e medulares, realizamos um estudo histológico em 1.179 placentas de Ifakara, na Tanzânia, uma área com transmissão intensa e perene da malária. Estudos imuno-histoquímico...
