Total: 1827

Evolution of primary HIV drug resistance in a subtype C dominated epidemic in Mozambique

PLos ONE; 7 (9), 2012
Objective: InMozambique, highly active antiretroviral treatment (HAART) was introduced in 2004 followed by decentralizationandexpansion, resulting inamorethan20-fold increase incoverageby2009. ImplementationofHIV drugresistancethresholdsurveys (HIVDR-TS) iscrucial inorder tomonitor theemergenceof transmi...

Mycobacterium tuberculosis Beijing genotype is associated with HIV infection in Mozambique

PLos ONE; 7 (9), 2012
The Beijing genotype is a lineage of Mycobacterium tuberculosis that is distributed worldwide and responsible for large epidemics, associated with multidrug-resistance. However, its distribution in Africa is less understood due to the lack of data. Our aim was to investigate the prevalence and possible t...

MLVA based classification of Mycobacterium tuberculosis complex lineages for a robust phylogeographic snapshot of its worldwide molecular diversity

PLos ONE; 7 (9), 2012
Multiple-locus variable-number tandem repeat analysis (MLVA) is useful to establish transmission routes and sources of infections for various microorganisms including Mycobacterium tuberculosis complex (MTC). The recently released SITVITWEB database contains 12-loci Mycobacterial Interspersed Repetitive ...

Protocol for a drugs exposure pregnancy registry for implementation in resource-limited settings

BMC pregnancy childbirth; 12 (89), 2012
Background: The absence of robust evidence of safety of medicines in pregnancy, particularly those for major diseases provided by public health programmes in developing countries, has resulted in cautious recommendations on their use. We describe a protocol for a Pregnancy Registry adapted to resource-li...

Representações Sociais de Doença Mental: Um Estudo Exploratório com Leigos, Profissionais de Saúde e Curandeiros em Maputo

What is now referred to by western societies as mental illness, was - and in some way still is – understood along the centuries using different interpretations. Associated with each of these interpretations are specifically, an historic moment, and cultural meanings vast and complex. The concentrati...

Performance of the PointCare NOW system for CD4 counting in HIV patients based on five independent evaluations

PLos ONE; 7 (8), 2012
Introduction: Point-of-care (POC) CD4 testing can improve access to treatment by enabling decentralization and reducing patient loss-to-follow-up. As new POC CD4 technologies become available, their performance should be assessed before widespread deployment. This study reports the findings of five indep...

A cross-sectional study of sub-clinical Plasmodium falciparum infection in HIV-1 infected and uninfected populations in Mozambique, South-Eastern Africa

Malar. j. (Online); 11 (252), 2012
Background: Plasmodium falciparum and HIV-1 infection cause substantial morbidity and mortality in sub-Saharan Africa. Increasing evidence suggests these two pathogens interact negatively when infecting the same individual. Methods: A cross-sectional study among HIV-1 infected and uninfected populations...