Chaccour, carlos;
Zulliger, rose;
Wagman, joe;
Casellas, aina;
Nacima, amilcar;
Elobolobo, eldo;
Savaio, binete;
Saifodine, abuchahama;
Fornadel, christen;
Richardson, jason;
Robertson, molly;
Saute, francisco.
Attaining the goal of reducing the global malaria burden is threatened by recent setbacks in maintaining the effectiveness of vector control interventions partly due to the emergence of pyrethroid resistant vectors. One potential strategy to address these setbacks could be combining indoor residual spray...
Nhama, abel;
Nhamússua, lídia;
Macete, eusébio;
Bassat, quique;
Salvador, crizolgo;
Enosse, sónia;
Candrinho, baltazar;
Carvalho, eva;
Nhacolo, arsénio;
Chidimatembue, arlindo;
Saifodine, abuchahama;
Zulliger, rose;
Lucchi, naomi;
Svigel, samaly s;
Moriarty, leah f;
Halsey, eric s;
Mayor, alfredo;
Aide, pedro.
Background: Artemisinin-based combination therapy (ACT) has been the recommended first-line treatment for uncomplicated malaria in Mozambique since 2006, with artemether–lumefantrine (AL) and amodiaquine–artesunate (AS–AQ) as the first choice. To assess efficacy of currently used ACT, an in vivo...
Moçambique/epidemiologia,
Artemeter/administração & dosagem,
Artesunato/administração & dosagem,
Algoritmos,
Malária Falciparum,
Malária/tratamento farmacológico,
Lumefantrina,
Infecções,
Eficácia/métodos,
34628,
Pacientes,
Parasitos,
Perda de Seguimento,
Reação em Cadeia da Polimerase,
Recidiva,
Segurança,
Terapêutica,
Técnicas de Diagnóstico Molecular
Galatas, Beatriz;
Mayor, Alfredo;
Gupta, Himanshu;
Balanza, Núria;
Jang, Ihn Kyung;
Nhamussua, Lidia;
Simone, Wilson;
Cistero, Pau;
Chidimatembue, Arlindo;
Munguambe, Humberto;
Saute, Francisco;
Aide, Pedro;
Bassat, Quique.
An ultrasensitive malaria rapid diagnostic test (RDT) was recently developed for the improved detection of low-density Plasmodium falciparum infections. This study aimed to compare the diagnostic performance of the PfHRP2-based Abbott Malaria Ag P. falciparum ultrasensitive RDT (uRDT) to that of the conv...
Antígenos de Protozoários/genética,
Parasitologia/métodos,
d0077700,
d0126800,
Moçambique,
Antígenos de Protozoários/sangue,
Estudos Transversais,
Teste em Amostras de Sangue Seco/métodos,
Teste em Amostras de Sangue Seco/estatística & dados numéricos,
Malária Falciparum/diagnóstico,
Parasitologia/estatística & dados numéricos,
Plasmodium falciparum/genética
Galatas, beatriz;
MontañàI, julia;
HamidoI, camilo;
Munguambe, humberto;
Wilson, Emily;
NhamussuaI, lidia;
GuinovartI, caterina;
SolerI, helena martı;
Saute, francisco;
Muguande, olinda3;
Maartens, francois4;
Luis, fabião;
Paaijmans, krijn;
Menéndez, clara;
Bassat, quique;
Mayor, alfredo;
Macete, eusebio;
Rabinovich, regina;
Alonso, pedro L;
Candrinho, baltazar;
Aide, pedro.
Background: Malaria eradication remains the long-term vision of the World Health Organization (WHO). However, whether malaria elimination is feasible in areas of stable transmission in sub-Saharan Africa with currently available tools remains a subject of debate. This study aimed to evaluate a multiphase...
Huijben, silvie;
Macete, eusebio;
Ngoma, ghyslain mombo;
Ramharter, michael;
Kariuki, Simon;
Desai, meghna;
Shi, ya ping;
Uberegui, estefania;
Mwangoka, grace;
Massougbodji, achille;
Cot, michel;
Ndam, nicaise tuikue;
Gupta, himanshu;
Cisteró, pau;
Aponte, john, j;
González, raquel;
Menéndez, clara;
Mayor, alfredo.
Background: Innovative approaches are needed to limit antimalarial resistance evolution. Understanding the role of intermittent preventive treatment in pregnancy (IPTp) on the selection for resistance and the impact such selection has on pregnancy outcomes can guide future interventions.
Methods: Plasmod...
Em Moçambique a malária é responsável por 60% de todas as admissões pediátricas, por 40% do total de consultas e ainda por 30% de todas as mortes registadas nos hospitais (2).Com vista a reverter esse cenário, o governo moçambicano, por intermédio do Programa Nacional de Combate à Malária (PCN...
Malária/epidemiologia,
Malária Aviária,
Moçambique/epidemiologia,
Artemeter/uso terapêutico,
Artemeter/provisão & distribuição,
Lumefantrina/uso terapêutico,
Lumefantrina/provisão & distribuição,
Cuidados Médicos/métodos,
Malária Falciparum/diagnóstico,
Malária Falciparum/tratamento farmacológico,
Malária Falciparum/prevenção & controle,
Malária Falciparum/transmissão,
Anopheles/virologia
Gupta, himanshu;
Galatas, beatriz;
Matambisso, gloria;
Nhamussua, lidia;
Cisteró, pau;
Bassat, quique;
Casellas, aina;
Macete, eusebio;
Aponte, john, j;
Sacoor, charfudin;
Alonso, pedro;
Saúte, francisco;
Guinovart, caterina;
Aide, pedro;
Mayor, alfredo.
Background: Poor knowledge on the afebrile Plasmodium falciparum biology limits elimination approaches to target asymptomatic malaria. Therefore, the association of parasite factors involved in cytoadhesion, parasite multiplication and gametocyte maturation with afebrile malaria was assessed.
Methods: Pl...
Dobaño, Carlota;
Quintó, Llorenç;
Barbosa, Arnoldo;
Rodríguez, Mauricio H;
Jiménez, Alfons;
Groves, Penny L;
Santano, Rebeca;
Bassat, Quique 124;
Aponte, John J;
Guinovart, Caterina;
Doolan, Denise L;
Alonso, Pedro L 123.
The effect of timing of exposure to first Plasmodium falciparum infections during early childhood on the induction of innate and adaptive cytokine responses and their contribution to the development of clinical malaria immunity is not well established. As part of a double-blind, randomized, placebo-contr...
Sevene, esperança;
Banda, clifford G;
Mukaka, mavuto;
Maculuve, sonia;
Vala, anifa;
Macuacua, salésio;
Piqueras, mireia;
Phiri, linda kalilani;
Mallewa, jane;
Terlouw, dianne J;
Khoo, saye H;
Lalloo, david G;
Mwapasa, victor.
Background: HIV-infected individuals on antiretroviral therapy (ART) require treatment with artemisinin-based combination therapy (ACT) when infected with malaria. Dihydroartemisinin–piperaquine (DPQ) is recommended for treatment of Plasmodium falciparum malaria, but its efcacy and safety has not been ...
Gupta, himanshu;
Galatas, beatriz;
Matambisso, gloria;
Nhamussua, lidia;
Cisteró, pau;
Bassat, quique;
Casellas, aina;
Macete, eusébio;
Aponte, john J;
Sacoor, charfudin;
Alonso, pedro;
Saúte, francisco;
Guinovart, caterina;
Aide, pedro;
Mayor, alfredo.
Background: Poor knowledge on the afebrile Plasmodium falciparum biology limits elimination approaches to target asymptomatic malaria. Therefore, the association of parasite factors involved in cytoadhesion, parasite multiplication and gametocyte maturation with afebrile malaria was assessed.
Methods: Pl...
