Resultados: 28

Evaluation of the Ogawa-Kudoh method for tuberculosis isolation in two health units in Mozambique

Background: Mozambique is among the highest tuberculosis, tuberculosis–HIV and multidrug-resistant-tuberculosis burden countries. Although molecular technologies are available in-country, mycobacterial isolation through culture remains an important tool for tuberculosis diagnostics and drug susceptibil...

Tuberculosis bacillary load, an early marker of disease severity: the utility of tuberculosis Molecular Bacterial Load Assay

Thorax; 75 (7), 2020
In this comparative biomarker study, we analysed 1768 serial sputum samples from 178 patients at 4 sites in Southeast Africa. We show that tuberculosis Molecular Bacterial Load Assay (TB-MBLA) reduces time-to-TB-bacillary-load-result from days/weeks by culture to hours and detects early patient treatment...

HIV prevalence and TB in migrant miners communities of origin in Gaza Province, Mozambique: the need for increasing awareness and knowledge

PLos ONE; 15 (4), 2020
As part of ongoing efforts to generate evidence needed on HIV and tuberculosis (TB) to inform policies and programs aimed to improve the health outcomes of migrants and communities affected by migration and mining, a preliminary investigation was conducted through a biological and behavioral (BBS) approa...

Directriz nacional para tratamento da tuberculose latente
National Guideline for the Treatment of Latent Tuberculosis

A Tuberculose Latente (TBL) é definida como um estado de resposta imunológica persistente à estimulação pelo antígeno do Mycobacterium tuberculosis sem evidência de manifestação clínica da doença activa. A probabilidade de progressão da infecção para doença activa depende de vários factor...

Clonal expansion across the seas as seen through CPLP-TB database: A joint effort in cataloguing Mycobacterium tuberculosis genetic diversity in Portuguese-speaking countries

Infect. gent. evol; 72 (), 2019
Tuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tube...

Manual para o manejo da tuberculose na criança, no adolescente e na mulher grávida

Estima-se que um terço da população mundial esteja infectada pelo Mycobacterium tuberculosis. Segundo a Organização Mundial de Saúde (OMS) em 2017, 10 milhões de pessoas de todas idades contraíram a Tuberculose (TB) no mundo, sendo que 1 milhão de casos afectaram crianças dos 0-14 anos e destes...

Mapeamento e distribuição dos isolados do complexo mycobacterium tuberculosis provenientes de casos de tuberculose bovino em Moçambique
Mapping and distribution of mycobacterium tuberculosis complex isolates from bovine tuberculosis cases in Mozambique

A tuberculose bovina (bTB) é um problema sanitário importante em Moçambique e ainda a espera de uma ação organizada por parte dos Serviços Veterinários Oficiais. O presente estudo teve por objetivo investigar e mapear os genótipos de Mycobacterium bovis circulantes no país e paralelamente maximi...

Tuberculosis Case Finding With Combined Rapid Point-of-Care Assays (Xpert MTB/RIF and Determine TB LAM) in HIV-Positive Individuals Starting Antiretroviral Therapy in Mozambique

Clin. infect. dis; 65 (11), 2017
Tuberculosis is a major health concern in several countries, and effective diagnostic algorithms for use in human immunodeficiency virus (HIV)–positive patients are urgently needed. Methods. At prescription of antiretroviral therapy, all patients in 3 Mozambican health centers were screened for tubercu...

Drug-resistant tuberculosis in Central Mozambique: the role of a rapid genotypic susceptibility testing

BMC infect. dis; 16 (423), 2016
Background: Genotypic molecular testing may be very helpful for tuberculosis (TB) drug-resistance surveillance and for treatment guidance in low resource settings. Methods: Descriptive analysis of M. tuberculosis isolates from Beira Central Hospital, Mozambique, during 2014-2015. Genotype MTBDRplus and ...

Perfil de sensibilidade dos isolados de Mycobacterium tuberculosis de pacientes com tuberculose e coinfectados TB/HIV na cidade da Beira, Sofala, Moçambique

A tuberculose (TB) é uma doença infecciosa que ameaça a humanidade há séculos. Recentemente grandes avanços foram conseguidos no combate à tuberculose, entretanto a resistência bacilar e a coinfecção pelo Vírus de Imunodeficiência Humana (HIV) persistem como os principais desafios dos program...