Resultados: 284

Prevalência da coinfecção HIV e Sífilis em mulheres grávidas em Moçambique

Em 2013, havia no mundo 3,2 milhões de crianças vivendo com HIV, com 91% de infecções ocorrendo em crianças na África subsaariana, através da transmissão de mãe para filho (Transmissão vertical -TV). E sem nenhuma intervenção, o risco de TV varia de 15% a 25% nos países desenvolvidos e de 25...

Reducing mortality in HIV-infected infants and achieving the 90-90-90 target through innovative diagnosis approaches

J. int. aids soc; 18 (6), 2015
Introduction: Despite significant gains in access to early infant diagnosis (EID) over the past decade, most HIV-exposed infants still do not get tested for HIV in the first two months of life. For those who are tested, the long turnaround time between when the sample is drawn and when the results are re...

Sustainable HIV Treatment in Africa through Viral Load-Informed Differentiated Care

Nature (Lond.); 528 (7580), 2015
There are inefficiencies in current approaches to monitoring patients on antiretroviral therapy (ART) in sub-Saharan Africa. Patients typically attend clinics every 1–3 months for clinical assessment, with clinic costs being comparable with costs of drugs themselves, CD4 counts are measured every 6 mon...

Impact and Cost of the HIV/AIDS National Strategic Plan for Mozambique, 2015-2019--Projections with the Spectrum/Goals Model

PLos ONE; 10 (11), 2015
Mozambique continues to face a severe HIV epidemic and high cost for its control, largely born by international donors. We assessed feasible targets, likely impact and costs for the 2015-2019 national strategic HIV/AIDS plan (NSP). Methods: The HIV epidemic and response was modelled in the Spectrum/Goal...

Post-ART Symptoms Were Not the Problem: A Qualitative Study on Adherence to ART in HIV-Infected Patients in a Mozambican Rural Hospital

PLos ONE; 10 (9), 2015
Objective: The objective of this qualitative study was to explore how clinical symptoms may affect adherence to antiretroviral therapy (ART) in HIV patients, and to explore factors, perceptions and attitudes related to adherence to therapy. Design: A qualitative study was carried out in the context of th...

CD4(+)CD25(High) Treg cells in HIV/HTLV co-infected patients with neuropathy: high expression of Alpha4 integrin and lower expression of Foxp3 transcription factor

BMC immunol. (Online); 52 (16), 2015
Regulatory CD4 T cells (Tregs) are critical in maintaining the homeostasis of the immune system. Quantitative or phenotypic alterations and functional impairment of Tregs have been associated with the development of pathologies including those of the central nervous system. Individuals with HIV-1/HTLV-1 ...

Implementation and Operational Research: Expedited Results Delivery Systems Using GPRS Technology Significantly Reduce Early Infant Diagnosis Test Turnaround Times

The objective of this study was to quantify the impact of a new technology to communicate the results of an infant HIV diagnostic test on test turnaround time and to quantify the association between late delivery of test results and patient loss to follow-up. We used data collected during a pilot impleme...

Determinants of virological failure and antiretroviral drug resistance in Mozambique

J. antimicrob. chemother; 70 (9), 2015
Objectives: The objective of this study was to inform public health actions to limit first-line ART failure and HIV drug resistance in Mozambique. Methods: This was a cross-sectional study. HIV-1-infected adults on first-line ART for at least 1 year attending routine visits in the Manhiça District Hospi...

Implementation of Point-of-Care Diagnostics Leads to Variable Uptake of Syphilis, Anemia and CD4+ T-Cell Count Testing in Rural Maternal and Child Health Clinics

PLos ONE; 10 (8), 2015
Introduction: Anemia, syphilis and HIV are high burden diseases among pregnant women in sub-Saharan Africa. A quasi-experimental study was conducted in four health facilities in Southern Mozambique to evaluate the effect of point-of-care technologies for hemoglobin quantification, syphilis testing and CD...

Implementation of Point-of-Care Diagnostics Leads to Variable Uptake of Syphilis, Anemia and CD4+ T-Cell Count Testing in Rural Maternal and Child Health Clinics
Implementation of Point-of-Care Diagnostics Leads to Variable Uptake of Syphilis, Anemia and CD4+ T-Cell Count Testing in Rural Maternal and Child Health Clinics

PLos ONE; 10 (8), 2015
A anemia, a sífilis e o VIH são doenças de grande impacto entre as mulheres grávidas na África Subsariana. Foi realizado um estudo quase experimental em quatro unidades de saúde no sul de Moçambique para avaliar o efeito das tecnologias no local de atendimento para quantificação de hemoglobina, ...