Human immunodeficiency virus (HIV)-1 infection has an important impact on malaria. Plasmodium falciparum
and HIV-1 co-infected patients (Pf/HIV) present with a high degree of anaemia, enhanced parasitaemia and decreased
CD4+ T cell counts, which increase the risk of developing severe malaria. In addition...
Background: Plasmodium falciparum and HIV-1 infection cause substantial morbidity and mortality in sub-Saharan Africa. Increasing evidence suggests these two pathogens interact negatively when infecting the same individual.
Methods: A cross-sectional study among HIV-1 infected and uninfected populations...
Quelhas, Diana;
Puyol, Laura;
Quinto, Llorenç;
Nhsmpossa, Tacilta;
Casas, Elisa Serra;
Macete, Eusébio;
Aide, Pedro;
Sanz, Sergi;
Aponte, John J;
Doolan, Denise L;
Menendez, Clara;
Dobano, Carlota.
Cytokines and chemokines are key mediators of anti-malarial immunity. We evaluated whether Intermittent Preventive Treatment in infants with Sulfadoxine-Pyrimethamine (IPTi-SP) had an effect on the acquisition of these cellular immune responses in Mozambican children. Multiple cytokines and chemokines we...
Quelhas, diana;
Puyol, Laura;
Quintó, llorenç;
Nhampassa, tacilta;
Cases, elisa serra;
Macete, eusébio;
Sanz, sergi;
Aponte, johs j;
Alonso, pedro;
Menéndez, clara;
Dobaño, carlota;
Doohan, denise.
Cytokines and chemokines are key mediators of anti-malarial immunity. We evaluated whether Intermittent Preventive Treatment in infants with Sulfadoxine-Pyrimethamine (IPTi-SP) had an effect on the acquisition of these cellular immune responses in Mozambican children. Multiple cytokines and chemokines we...
d0162070,
d0117390,
d0109490,
d0109630,
d0189250,
d0134130,
d0138120,
Antimaláricos/uso terapêutico,
Antimaláricos/farmacologia,
Malária Falciparum/epidemiologia,
Malária Falciparum/prevenção & controle
Campos, josé j;
Dobaño, carlota;
Sacarlal, jahit;
Prefeito, alfredo;
Angov, evelina;
Dutta, shutij;
Chitnis, chetan;
Machete, eusébio;
Aponte, Joao j;
Alonso, pedro l.
Partial protective efficacy lasting up to 43 months after vaccination with the RTS,S malaria vaccine has been reported in one cohort (C1) of a Phase IIb trial in Mozambique, but waning efficacy was observed in a smaller contemporaneous cohort (C2). We hypothesized that low dose exposure to asexual stage ...
Malaria is among the factors thought to be involved in the pathogenesis of endomyocardial fibrosis (EMF), a restrictive cardiomyopathy of unclear etiology, with no specific therapy, which affects predominantly children and adolescents. In Africa, regions endemic with EMF are also areas with high prevalen...
Quelhas, Diana;
Jimenez, Alfons;
Quito, Llorenç;
Casas, Elisa Serra;
Mayor, Alfredo a d;
Cistero, Pau;
Puyol, Laura;
Wilson, Danny W. e;
Richards, Jack S;
Nhampossa, Tacilta;
Macete, Eusebioa;
Aide, Pedro;
Sanz, Sergi;
Aponte, John J;
Alonso, Pedro L;
Beeson, James G;
Menendez, Clara;
Dobano, Carlota.
This study aimed to evaluate whether intermittent preventive treatment in infants with sulfadoxine-pyrimethamine (IPTi-SP) had an effect on the acquisition of IgG against Plasmodium falciparum variant surface antigens (VSA) and growth-inhibitory antibodies in Manhiça, Mozambique. In addition, we assesse...
Anticorpos Antiprotozoários,
d0109630,
Anticorpos Antiprotozoários/sangue,
Formação de Anticorpos/efeitos da radiação,
Antígenos de Protozoários/imunologia,
Antígenos de Superfície/imunologia,
Protocolos de Quimioterapia Combinada Antineoplásica/química,
Imunoglobulina G/sangue,
Malária Falciparum/sangue,
Malária Falciparum/imunologia,
Malária Falciparum/epidemiologia,
Malária Falciparum/prevenção & controle,
Proteínas de Membrana/imunologia,
Plasmodium falciparum/imunologia,
Plasmodium falciparum/patogenicidade,
Proteínas de Protozoários/imunologia,
Moçambique
Gillet, philippe;
Annelies, Scheirlinck;
Stokx, jocelijn;
Weggheleire, anja de;
Chaúque, hélder s;
Canhanga, oreana D J V;
Tadeu, benvindo t;
Mosse, carla d d;
Tiago, armindo;
Mabunda, Samuel;
Bruggeman, cathrien;
Bottieau, emmanuel;
Jacobs, jan.
Background: Prozone means false-negative or false-low results in antigen-antibody reactions, due to an excess of either antigen or antibody. The present study prospectively assessed its frequency for malaria rapid diagnostic tests (RDTs) and Plasmodium falciparum samples in an endemic field setting.
Met...
Serra-Casa, Elisa;
Menéndez, Clara;
Dobaño, Carlota;
Bardají, Azucena1 2;
Quintó, Llorençc;
Ordi, Jaume;
Sigauque, Betuel;
Cisteró, Pau;
Mandomando, Inácio;
Alonso, Pedro L;
Mayor, Alfredo.
Pregnant women are susceptible to Plasmodium falciparum parasites that sequester in the placenta. The massive accumulation of infected erythrocytes in the placenta has been suggested to trigger the deleterious effects of malaria in pregnant women and their offspring. The risk of malaria is also high duri...
To determine the prevalence of acute HIV infection (AHI) within the HIV-seronegative adult population presenting with reported fever in a district hospital in southern Mozambique and evaluate clinical, immunological and virological parameters of AHI.
Design:
This is a prospective observational study.
...
