Resultados: 65

Severe malaria and concomitant bacteraemia in children admitted to a rural Mozambican hospital

Trop. med. int. health; 14 (9), 2009
Objectives: To describe the prevalence, aetiology and prognostic implications of coexisting invasive bacterial disease in children admitted with severe malaria in a rural Mozambican Hospital. Methods: Retrospective study of data systematically collected from June 2003 to May 2007 in a rural Mozambican ho...

Cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) in Mozambique and the United Republic of Tanzania

Bull. W.H.O. (Online); 87 (2), 2009
Objective: To estimate the cost-effectiveness of malaria intermittent preventive treatment in infants (IPTi) using sulfadoxine-pyrimethamine (SP). Methods: In two previous IPTi trials in Ifakara (United Republic of Tanzania) and Manhiça (Mozambique), SP was administered three times to infants before 9 m...

A country-wide malaria survey in Mozambique. II. Malaria attributable proportion of fever and establishment of malaria case definition in children across different epidemiological settings

Malar. j. (Online); 8 (74), 2009
Background: Protection against clinical malaria episodes is acquired slowly after frequent exposure to malaria parasites. This is reflected by a decrease with increasing age in both parasite density and incidence of clinical episodes. In many settings of stable malaria transmission, the presence...

Spatio-seasonal modeling of the incidence rate of malaria in Mozambique

Malar. j. (Online); 7 (228), 2008
Background: The objective was to study the seasonal effect on the spatial distribution of the incidence of malaria in children under 10 years old living in the Manhiça district, Mozambique. Methods: The data of the clinical malaria incidence were obtained from a study of two cohorts of children followed...

Molecular Markers of Resistance to Sulfadoxine-Pyrimethamine during Intermittent Preventive Treatment for Malaria in Mozambican Infants

J. infect. dis; 197 (12), 2008
Background. Intermittent preventive treatment in infants (IPTi) with sulfadoxine-pyrimethamine (SP) is a po tential malaria control strategy. There is concern about the impact that increasing in vivo resistance to SP has on the efficacy of IPTi, as well as about the potential contribution of IPTi to incr...

Contribuição para o estudo de resistência aos antimaláricos e análise de marcadores moleculares de Plasmodium falciparum e do hospedeiro humano, em Maputo, Moçambique
Contribution to the study of antimalarial resistance and analysis of molecular markers of Plasmodium falciparum and the human host, in Maputo, Mozambique

A malária é de longe a doença parasitária mais importante em Moçambique, constituindo um grave problema de saúde pública no País. Apesar de se considerar que um diagnóstico atempado e um tratamento correcto são os elementos básicos para um programa de controlo da malária bem sucedido, nas úl...

Evaluation of two formulations of adjuvanted RTS, S malaria vaccine in children aged 3 to 5 years living in a malaria-endemic region of Mozambique: a Phase I/IIb randomized double-blind bridging trial

Trials; 8 (11), 2007
Results: Both vaccines were safe and had similar reactogenicity profiles. All subjects with paired pre and post-vaccination samples showed a vaccine response with respect to anti-circumsporozoite (CS) antibodies irrespective of initial anti-CS serostatus. Geometric mean titers (GMTs) were 191 EU/ml (95...

Safety and immunogenicity of the RTS, S/AS02A candidate malaria vaccine in children aged 1–4 in Mozambique

Trop. med. int. health; 29 (1), 2007
The development of a malaria vaccine remains a public health priority for sub-Saharan Africa. RTS,S/AS02A candidate malaria vaccine has been shown to be safe and immunogenic in previous studies in adults and staggered dose-escalation studies in children in The Gambia. However, genetic features and the in...

Community incidences of respiratory infections in an actively followed cohort of children <1 year of age in Manhiça, a rural area of southern Mozambique

Trop. med. int. health; 11 (3), 2006
Objective: To estimate the community incidence-rates of respiratory infections among infants in Manhiça, southern Mozambique, and to determine risk factors associated with these infections. Methods: A cohort of children <1 year of age were visited at home every week until they turned one. During the vis...

The epidemiology and the burden of Malaria in Mozambique

Malaria occurs mostly in the tropical regions of the world. Sub-Saharan Africa is the area most affected. The occurrence of a very efficient mosquito vectors Anopheles gambiae complex and Anopheles funestus group sustain high transmission of the Plasmodium falciparum, the most predominant and deadly mala...