Efficacy and safety of pyronaridine-artesunate (PYRAMAX) for the treatment of P. falciparum uncomplicated malaria in African pregnant women (PYRAPREG): study protocol for a phase 3, non-inferiority, randomised open-label clinical trial
BMJ Open; 13 (10), 2023
Malaria infection during pregnancy increases the risk of low birth weight and infant mortality and should be prevented and treated. Artemisinin-based combination treatments are generally well tolerated, safe and effective; the most used being artemether-lumefantrine (AL) and dihydroartemisinin-piperaquin...
Malária Falciparum/terapia, Artemisininas/efeitos da radiação, Combinação Arteméter e Lumefantrina, Ensaios Clínicos Controlados Aleatórios como Assunto, Gestantes, Controle de Infecções, Parasitologia, População da África Subsaariana, Artemeter/uso terapêutico, Antimaláricos/efeitos da radiação, Moçambique/epidemiologia