Moçambique tem uma das maiores epidemias de HIV em crianças no continente africano. Estimava-se que 150 mil crianças entre 0 a 14 anos viviam com HIV em 20191 . Embora o acesso ao Tratamento Antirretroviral (TARV) ainda constitua um desafio, com apenas 63% das crianças vivendo com HIV em TARV em 2019...
Background: Early infant diagnosis (EID) of HIV-exposed and initiation of HIV-positive infants on anti-retroviral therapy (ART) requires a well-coordinated cascade of care. Loss-to-follow-up (LTFU) can occur at multiple steps and effective EID is impeded by human resource constraints, difficulty with pat...
It is well known that it is more reliable to investigate the effects of several covariates simultaneously rather than one at time. Similarly, it is more informative to model responses simultaneously, as more often than not, the multiple responses from the same subject are correlated. This is particularly...
Megg, Bindiya;
Vojnov, Lara;
Mabunda, Nédio;
Vubil, Adolfo;
Zitha, Alcina;
Tobaiwa, Ocean;
Mudenyanga, Chishamiso;
Mutsaka, Dadirayi;
Bollinger, Timothy;
Loquiha, Osvaldo;
Pete, Trevor F;
Jan, Ilesh V.
Worldwide only 43% of infants infected with HIV have access to antiretroviral treatment (ART). Despite significant global efforts to expand access to paediatric treatment, coverage lags behind adult ART and may not reach the 90-90-90 goals by 2020 as set by UNAIDS [2]. Resolving this paediatric ART gap i...
n well-resourced settings, reduced circulating maternal free placental growth factor (PlGF) aids in either predicting or confirming the diagnosis of preeclampsia, fetal growth restriction, stillbirth, preterm birth, and delivery within 14 days of testing when pre-eclampsia is suspected. This operational ...
d0109490,
Biomarcadores/sangue,
d0084230,
Moçambique,
Pré-Eclâmpsia/sangue,
d0112560,
d0053170,
Pressão Arterial,
Disruptores Endócrinos,
Diagnóstico Precoce,
Fator de Crescimento Placentário/sangue,
Pré-Eclâmpsia/diagnóstico,
Pré-Eclâmpsia/etiologia,
Pré-Eclâmpsia/fisiopatologia,
Valor Preditivo dos Testes,
Nascimento Prematuro/etiologia,
Curva ROC,
Reprodutibilidade dos Testes,
Fatores de Risco,
Natimorto,
Saúde da População Urbana
A transmissão vertical é a principal via de infecção pelo Virus de Imunodeficiência
Adquirida (HIV) em crianças e pode ocorrer durante a gestação (10-25%), durante o parto (35-50%), ou depois do parto através do aleitamento materno (20-25%). Na ausência de Tratamen...
Introduction: The scale-up of effective HIV viral load (VL) testing is an urgent public health priority. Implementation of testing is supported by the availability of accurate, nucleic acid based laboratory and point-of-care (POC) VL technologies and strong WHO guidance recommending routine testing to id...
Meggi, Bindiya;
Bollinger, Timothy;
Mabunda, Nédio;
Vubil, Adolfo;
Tobaiwa, Ocean;
Quevedo, Jorge I;
Loquiha, Osvaldo;
Vojnov, Lara;
Peter, Trevor F;
Jani, Ilesh V.
The long delay in returning test results during early infant diagnosis of HIV (EID) often
causes loss-to-follow-up prior to antiretroviral treatment (ART) initiation in resource-limited
settings. A point-of-care (POC) test may help overcome these challenges. We evaluated
the performance of the LYNX p24 A...
Fármacos Anti-HIV/uso terapêutico,
Diagnóstico Precoce,
Infecções por HIV/diagnóstico,
Infecções por HIV/terapia,
Infecções por HIV/epidemiologia,
Infecções por HIV/imunologia,
Testes Imediatos/normas,
Reprodutibilidade dos Testes,
Moçambique/epidemiologia,
Sensibilidade e Especificidade,
HIV-1/imunologia
Introduction: Despite significant gains in access to early infant diagnosis (EID) over the past decade, most HIV-exposed infants still do not get tested for HIV in the first two months of life. For those who are tested, the long turnaround time between when the sample is drawn and when the results are re...
Introduction: Prevention of acute HIV infections in pregnancy is required to achieve elimination of pediatric HIV. Identification and support for HIV negative pregnant women and their partners, particularly serodiscordant couples, are critical. A mixed method study done in Southern Mozambique estimated H...
