Sebastião, Cruz S;
Sebastião, Cruz S;
Sebastião, Cruz S;
Pingarilho, Marta;
Bathy, Jamila;
Bonfim, Elizângela;
Toancha, Katia;
Miranda, Mafalda NS;
Martins, M Rosário O;
Gomes, Perpétua;
Gomes, Perpétua;
Lázaro, Lazismino;
Pina-Araujo, Isabel;
Nhampossa, Tacilta;
Leal, Silvania;
Abecasis, Ana B;
Pimentel, Victor.
Background HIV-1 infections remain a global public health concern. Scaled-up antiretroviral treatment (ART) is
crucial for reducing morbidity and mortality related to HIV/AIDS. The emergence of drug-resistance mutations
(DRMs) compromises viral suppression and contributes to the continued HIV-1 transmiss...
Gray, Glenda E;
Mngadi, Kathryn;
Lavreys, Ludo;
Nijs, Steven;
Gilbert, Peter B;
Hural, John;
Hyrien, Ollivier;
Juraska, Michal;
Luedtke, Alex;
Mann, Philipp;
McElrath, M Juliana;
Odhiambo, Jackline A;
Stieh, Daniel J;
Duijn, Janine van;
Takalani, Azwidihwi N;
Willems, Wouter;
Tapley, Asa;
Tomaras, Georgia D;
Hoof, Johan Van;
Schuitemaker, Hanneke;
Swann, Edith;
Barouch, Dan H;
Kublin, James G;
Corey, Lawrence;
Pau, Maria G;
Buchbinder, Susan;
Tomaka, Frank.
Background: HIV type 1 (HIV-1) remains a global health concern, with the greatest burden in sub-Saharan Africa. Despite 40 years of research, no vaccine candidate has shown durable and protective efficacy against HIV-1 acquisition. Although pre-exposure prophylaxis in groups with high vulnerability can b...
In Mozambique, sexually transmitted infections (STIs) are estimated to be
prevalent, but diagnosis and treatment of curable STIs rely only on syndromic
management. We examined the prevalence of four non-viral STIs and HIV-1/2,
based on etiological diagnosis, associations with sociodemographic and
behavio...
Vubil, Adolfo;
Zicai, Ana Flora;
Sitoe, Nádia;
Nhachigule, Carina;
Costa, Paulino da;
Magul, Cacildo;
Meggi, Bindiya;
Viegas, Sofia;
Mabunda, Nédio;
Jani, Ilesh.
ABSTRACT Dried blood spot (DBS) may overestimate the viral RNA, mainly in patients
with low viral load (VL), due to proviral DNA and intracellular RNA. The Burnett and
HemaSpot provide integrated solutions for the collection, separation, and drying of
plasma from whole blood. This study aims to evalua...
Koofhethile, Catherine;
Rinaldi, Stefano;
Rassadkina, Yelizaveta;
Dinh, Vinh B;
Gao, Ce;
Pallikkuth, Suresh;
Broncano, Pilar Garcia;
Armas, Lesley R de;
Pahwa, Rajendra;
Cotugno, Nicola;
Vaz, Paula;
Lain, Maria Grazia;
Palma, Paolo;
G Yu, Xu;
Shapiro, Roger;
Pahwa, Savita;
Lichterfeld, Mathias.
With more than 1.7 million infected children worldwide, pediatric HIV-1 infection remains
a global health challenge; in 2020 alone, current estimates suggest that more than 150,000
children were newly infected with HIV-1 [1]. Most of these children are infected through
breastfeeding, but vertical mother-...
In 2021, there were more than 150,000 new HIV infections among children; however, only 52% of children living with HIV were on antiretroviral treatment (ART) [1]. Untreated infants and young children are at high risk for rapid disease progression and death [2, 3]; early diagnosis and rapid treatment can ...
Chissumba, Raquel Matavele;
Magul, Cacildo;
Macamo, Rosa;
Monteiro, Vânia;
Enosse, Maria;
Macicame, Ivalda;
Cumbane, Victória;
Bhatt, Nilesh;
Viegas, Sofia O;
Imbach, Michelle;
Eller, Leigh Anne;
Polyak, Christina S;
Kestens, Luc.
Background: Human immunodeficiency virus type 1 (HIV-1) causes impairment of T and B cell responses, which begins during the acute phase of infection and is not completely restored by antiretroviral treatment. Regulatory T cell (Tregs) can improve overall disease outcome by controlling chronic inflammati...
Diversidade de Anticorpos,
Linfócitos T CD4-Positivos,
Linfócitos T CD8-Positivos,
Infecções por HIV,
HIV-1,
Humanos,
Interleucina-2,
Metabolismo,
Ativação Linfocitária,
Moçambique/epidemiologia,
Linfócitos T Reguladores,
Doença Crônica/tendências
Objectives: Our study aimed to evaluate the stability of human immunodeficiency virus 1 (HIV-1) RNA on cobas plasma separation card (PSC) specimens for viral load (VL) testing after being exposed to varied temperatures and storage times.
Methods: For this purpose, venous PSC specimens were collected and ...
Anapakala, Elda Muianga;
Chongo, Patrina;
Barca, isis da;
Dimas, tomás;
Sitoe, Nadia;
Sebastião, Ruben;
Chongola, Francelino;
Pinto, Isabel;
Loquiha, Osvaldo;
Kidane, Solon;
Jani, Ilesh;
Viegas, Sofia.
WWDISA is an optional module of the DISA Laboratory Information system (LIS) that
offers a web portal that allows access to test results over the internet for patient clinical management. This study aims to assess the applicability of using the WWDISA web application, and the lessons learned from its ...
Anapakala, Elda Muianga;
Anapakala, Elda Muianga;
Chongo, Patrina;
Barca, Isis da;
Dimas, Tomás;
Sitoe, Nadia;
Sebastião, Ruben;
Chongola, Francelino;
Pinto, Isabel;
Loquiha, Osvaldo;
Kidane , Solon;
Jani, Ilesh;
Viegas, Sofia O.
WWDISA is an optional module of the DISA Laboratory Information system (LIS) that offers a web portal that allows access to test results over the internet for patient clinical management. This study aims to assess the applicability of using the WWDISA web application, and the lessons learned from its imp...
Sistemas de Informação,
Laboratórios,
Administração de Serviços de Saúde,
HIV,
Humanos,
Moçambique/epidemiologia,
África,
d0029840,
d0031950,
HIV-1,
Carga Viral
