Gupta, himanshu;
Bassat, quique;
Nhamussua, lidia;
Matambisso, gloria;
Cisteró, pau;
Huijben, silvie;
Chidimatembue, arlindo;
Galatas, beatriz;
Ménard, didier;
Ringwald, pascal;
Rabinovich, regina;
Alonso, pedro L;
Saute, francisco;
Assessor, pedro;
Prefeito, alfredo.
Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
Antimaláricos/administração & dosagem,
Antimaláricos/farmacologia,
Antimaláricos/uso terapêutico,
Artemisininas/administração & dosagem,
Artemisininas/farmacologia,
Artemisininas/uso terapêutico,
Protocolos de Quimioterapia Combinada Antineoplásica,
Resistência a Medicamentos/genética,
Malária/parasitologia,
Malária/prevenção & controle,
Moçambique,
Plasmodium falciparum/imunologia,
Plasmodium falciparum/genética,
Plasmodium falciparum/patogenicidade,
Polimorfismo Genético,
Proteínas de Protozoários/genética,
Proteínas de Protozoários/metabolismo,
Quinolinas/administração & dosagem,
Quinolinas/uso terapêutico,
Quinolinas/farmacologia
Dobaño, Carlota;
Quintó, Llorenç;
Barbosa, Arnoldo;
Rodríguez, Mauricio H;
Jiménez, Alfons;
Groves, Penny L;
Santano, Rebeca;
Bassat, Quique 124;
Aponte, John J;
Guinovart, Caterina;
Doolan, Denise L;
Alonso, Pedro L 123.
The effect of timing of exposure to first Plasmodium falciparum infections during early childhood on the induction of innate and adaptive cytokine responses and their contribution to the development of clinical malaria immunity is not well established. As part of a double-blind, randomized, placebo-contr...
Mocubi, Ana O;
Cebola, Bonifácio;
Muloliwa, Artur;
Sebastião, Frederico;
Sitefane, Samuel J;
Manafe, Naisa;
Gobe, Igor;
Lumbandali, Norbert;
Keates, Ashley;
Stickland, Nerolie;
Chan, Yi-Kai;
Stewart, Simon.
There is a paucity of primary data to understand the overall pattern of disease and injuries
as well as related health-service utilization in resource-poor countries in Africa. To generate reliable and robust data describing the pattern of emergency presentations attributable to communicable disease (CD)...
Malaria is the most common and dangerous parasitic disease, being
responsible every year for nearly half a million deaths, and an estimated
219 million clinical cases, globally [1]. The devastating short-term effects that an acute malarial infection can have on any given individual
have been historically...
Objective: To describe the burden, clinical characteristics and prognostic factors of severe malnutrition in children under the age of 5 years.
Design: Retrospective study of hospital-based data systematically collected from January 2001 to December 2010.
Setting: Rural Mozambican district hospital.
Subj...
Instituições de Assistência Ambulatorial,
Aleitamento Materno,
Comorbidade,
Diarreia,
Mortalidade Hospitalar,
Hospitalização,
Hospitais de Distrito,
Vigilância da População,
Prevalência,
Estudos Retrospectivos,
População Rural,
Índice de Gravidade de Doença,
Desnutrição Proteico-Calórica/complicações,
Desnutrição Proteico-Calórica/epidemiologia,
Desnutrição Proteico-Calórica/mortalidade,
Desnutrição/complicações,
Desnutrição/epidemiologia,
Desnutrição/mortalidade,
Malária/parasitologia,
Moçambique/epidemiologia
Machado 1, Patrícia;
Manco, Licínio;
Gomes, Cláudia;
Mendes, Cristina;
Fernandes, Natércia;
Salomé, Graça;
Sitoe, Luis;
Chibute, Sérgio;
Langa, José;
Ribeiro, Letícia;
Miranda, Juliana;
Cano, Jorge;
Pinto, João;
Amorim, António;
Rosário, Virgílio E do;
Arez, Ana Paula.
Background: Pyruvate kinase (PK) deficiency, causing hemolytic anemia, has been associated to malaria protection and its prevalence in sub-Saharan Africa is not known so far. This work shows the results of a study undertaken to determine PK deficiency occurrence in some sub-Saharan African countries, as ...
África Subsaariana/epidemiologia,
Malária/parasitologia,
Doenças Endêmicas,
Genética,
Testes Genéticos,
Malária/epidemiologia,
Parasitologia,
Mutação,
Plasmodium,
Anemia/complicações,
Piruvato Quinase/genética,
Piruvato Quinase/deficiência
Aranda, C;
J, J Aponte;
Saute, F;
Casimiro, S;
Pinto, J;
Sousa, C;
V, Do Rosario;
V, Petrarca;
M, Dgedge;
P, Alonso.
From October 1997 to September 1998, an entomological survey was carried out in Manhiça, Mozambique, to describe the anopheline population and intensity of malaria transmission. Ten different huts were randomly selected for entomological surveillance throughout the year. CDC light trap collections were ...
We compared the distribution patterns of individual Plasmodium species and mixed-species infections in two geographically close endemic areas, but showing environmental differences. Comparisons concerned circulating Plasmodium infections in both human and mosquito vector populations in the dry and wet se...
Malária/epidemiologia,
Malária/parasitologia,
Moçambique,
Especificidade da Espécie,
Plasmodium ovale,
Coinfecção,
Malária Falciparum/diagnóstico,
Coinfecção/transmissão,
Plasmodium falciparum/isolamento & purificação,
Plasmodium ovale/isolamento & purificação,
Reação em Cadeia da Polimerase,
Moçambique/epidemiologia
Background: Falciparum malaria affects pregnant women, especially primigravidae, but before malaria control programmes targeted to them can be designed, a description of the frequency and parity pattern of the infection is needed. There is little information on the frequency and effect of submicroscopic ...
Para caracterizar as alterações histológicas nas placentas da malária e sua relação com a paridade e parasitemias maternas e medulares, realizamos um estudo histológico em 1.179 placentas de Ifakara, na Tanzânia, uma área com transmissão intensa e perene da malária. Estudos imuno-histoquímico...
