Background Mass drug administration (MDA) can rapidly reduce the burden of Plasmodium falciparum (Pf). However, concerns remain about its contribution to select for antimalarial drug resistance. Methods We used Sanger sequencing and real-time PCR to determine the proportion of molecular markers associate...
The effect of timing of exposure to first Plasmodium falciparum infections during early childhood on the induction of innate and adaptive cytokine responses and their contribution to the development of clinical malaria immunity is not well established. As part of a double-blind, randomized, placebo-contr...
Objective: To describe the burden, clinical characteristics and prognostic factors of severe malnutrition in children under the age of 5 years.
Design: Retrospective study of hospital-based data systematically collected from January 2001 to December 2010.
Setting: Rural Mozambican district hospital.
Subj...
We compared the distribution patterns of individual Plasmodium species and mixed-species infections in two geographically close endemic areas, but showing environmental differences. Comparisons concerned circulating Plasmodium infections in both human and mosquito vector populations in the dry and wet se...
Background: Falciparum malaria affects pregnant women, especially primigravidae, but before malaria control programmes targeted to them can be designed, a description of the frequency and parity pattern of the infection is needed. There is little information on the frequency and effect of submicroscopic ...
Para caracterizar as alterações histológicas nas placentas da malária e sua relação com a paridade e parasitemias maternas e medulares, realizamos um estudo histológico em 1.179 placentas de Ifakara, na Tanzânia, uma área com transmissão intensa e perene da malária. Estudos imuno-histoquímico...
