Barilar, ivan;
Fernando, Tatiana;
Utpatel, christian;
Abujate, cláudio;
Madeira, Carla, M;
José, benedita;
Mutaquiha, claudia;
Kranzer, katharina;
Niemann, tanja.
Background
In 2021, an estimated 4800 people developed rifampicin-resistant tuberculosis in Mozambique, 75% of which went undiagnosed. Detailed molecular data on rifampicin-resistant and multidrug-resistant (MDR) tuberculosis are not available. Here, we aimed at gaining precise data on the determinants o...
Olbrich, laura;
Verghese, Valsan, P;
Smith, zoe franckling;
Sabi, issa;
Ntinginya, Nyanda E;
Mfinanga, alfred;
Banze, denise;
Viegas, sofia omar;
Khosa, celso;
Semphere, robina.
Background Childhood tuberculosis remains a major cause of morbidity and mortality in part due to missed diagnosis. Diagnostic methods with enhanced sensitivity using easy-to-obtain specimens are needed. We aimed to assess the diagnostic accuracy of the Cepheid Mycobacterium tuberculosis Host Response pr...
Cervera, Belén Saavedra;
López, Mariana G;
Chiner-Oms, Álvaro;
García, Ana Maria;
Cancino-Muñoz, Irving;
Torres-Puente, Manuela;
Villamayor, Luis;
Carlos Madrazo-Moya, Carlos;
Mambuque, Edson;
Sequera, Guilherme Victor;
Respeito, Durval;
Blanco, Sílvia;
Augusto, Orvalho;
López-Varela, Elisa;
Garcia-Basteiro, Alberto L;
Comas, Iñaki.
Genomic studies of the Mycobacterium tuberculosis complex (MTBC) might shed light on the dynamics of its transmission, especially in high-burden settings, where recent outbreaks are embedded in the complex natural history of the disease. To this end, we conducted a 1 year prospective surveillance-based ...
This study evaluated a National External Quality Scheme Program for early infant diagnosis of HIV. Fourteen laboratory technicians participated, and nine testing panel cycles were sent between 2011 and 2014. The response rate was 100% for the first eight panels, and the number of technicians with a test ...
Background: Mozambique is among the highest tuberculosis, tuberculosis–HIV and multidrug-resistant-tuberculosis burden countries. Although molecular technologies are available in-country, mycobacterial isolation through culture remains an important tool for tuberculosis diagnostics and drug susceptibil...
Perdigão, joão;
Silva, carla;
Diniz, jaciara;
Pereira, catarina;
Machado, diana;
Ramos, jorge;
Silva, hugo;
Abilleira, fernanda;
Brum, clarice;
Reis, Ana, J.
Tuberculosis (TB) remains a major health problem within the Community of Portuguese Language Speaking Countries (CPLP). Despite the marked variation in TB incidence across its member-states and continued human migratory flux between countries, a considerable gap in the knowledge on the Mycobacterium tube...
A tuberculose (TB) é uma doença infecciosa que ameaça a humanidade há séculos. Recentemente grandes
avanços foram conseguidos no combate à tuberculose, entretanto a resistência bacilar e a coinfecção pelo
Vírus de Imunodeficiência Humana (HIV) persistem como os principais desafios dos program...
Farmacorresistência Bacteriana,
Mycobacterium tuberculosis/efeitos dos fármacos,
Genótipo,
Antibióticos Antituberculose/farmacologia,
Coinfecção,
Tuberculose Resistente a Múltiplos Medicamentos/microbiologia,
Prevalência,
Tuberculose/microbiologia,
Testes de Sensibilidade Microbiana,
Mycobacterium tuberculosis/genética,
Infecções por HIV/epidemiologia,
Moçambique/epidemiologia
Viegas, sofia omar;
Machado, adelina;
Groenheit, Ramona;
Ghebremichael, solomon;
Pennhag, alexandra;
Gudo, eduardo samo;
Cuna, zaina;
Langa, egídio;
Miotto, paolo;
Cirillo, Daniela, M.
The Beijing genotype is a lineage of Mycobacterium tuberculosis that is distributed worldwide and responsible for large epidemics, associated with multidrug-resistance. However, its distribution in Africa is less understood due to the lack of data. Our aim was to investigate the prevalence and possible t...
Multiple-locus variable-number tandem repeat analysis (MLVA) is useful to establish transmission routes and sources of infections for various microorganisms including Mycobacterium tuberculosis complex (MTC). The recently released SITVITWEB database contains 12-loci Mycobacterial Interspersed Repetitive ...
Técnicas de Tipagem Bacteriana,
Teorema de Bayes,
Loci Gênicos/genética,
Genótipo,
Internacionalidade,
Sequências Repetitivas Dispersas/genética,
Repetições de Microssatélites/genética,
Mycobacterium tuberculosis/classificação,
Mycobacterium tuberculosis/genética,
Filogenia,
Filogeografia
Viegas, sofia omar;
Machado, adelina;
Groenheit, Ramona;
Ghebremichael, solomon;
Pennhag, alexandra;
Gudo, paula, s;
Cuna, zaina;
Langa, egídio;
Miotto, paolo;
Cirillo, Daniela, M.
Background: Mozambique is one of the countries with the highest burden of tuberculosis (TB) in Sub-Saharan Africa, and information on the predominant genotypes of Mycobacterium tuberculosis circulating in the country are important to better understand the epidemic. This study determined the predominant s...
