Resultados: 16

Cost-effectiveness of rotavirus vaccination in Mozambique

Vaccine; 40 (36), 2022
Introduction: Rotavirus is one of the most common cause of severe gastroenteritis in children, with the largest mortality burden in low- and middle-income countries. To prevent rotavirus gastroenteritis, Mozambique introduced ROTARIX vaccine in 2015, however, its cost-effectiveness has never been establi...

Effectiveness of Monovalent Rotavirus Vaccine in Mozambique, a Country with a High Burden of Chronic Malnutrition

Vaccine; 10 (449), 2022
Mozambique introduced monovalent rotavirus vaccine (Rotarix®) in September 2015. We evaluated the effectiveness of Rotarix® under conditions of routine use in Mozambican children hospitalized with acute gastroenteritis (AGE). A test negative case-control analysis was performed on data collected during ...

Genetic characterisation of south african and mozambican bovine rotaviruses reveals a typical bovine-like artiodactyl constellation derived through multiple reassortment events

PloS pathog; 20 (2), 2022
This study presents whole genomes of seven bovine rotavirus strains from South Africa and Mozambique. Double-stranded RNA, extracted from stool samples without prior adaptation to cell culture, was used to synthesise cDNA using a self-annealing anchor primer ligated to dsRNA and random hexamers. The cDNA...

Sucessos e desafios da implementação da Vigilância Nacional de Diarreias (ViNaDia) em Moçambique

Introdução: o Instituto Nacional de Saúde de Moçambique, implementou a Vigilância Nacional de Diarreias (ViNa Dia) em 2014 cujo principal objectivo é determinar a carga de diarreias em crianças dos 0 aos 14 anos de idade, e os agentes etiológicos associados, em quatro províncias de Moçambique....

Rotavirus A infection in pre- and post-vaccine period: Risk factors, genotypes distribution by vaccination status and age of children in Nampula Province, Northern Mozambique (2015-2019)

PLos ONE; (), 2021
Globally, Rotavirus A (RVA) remains the leading cause of severe acute gastroenteritis associated with high childhood hospitalization and mortality, accounting for an estimated 128,515 deaths among children under five years old in 2016 [1, 2]. In Sub-Saharan Africa, RVA associated morbidity and mortality ...

Prevalence and genome characterization of porcine rotavirus A in southern Mozambique

Infect. gent. evol; 87 (), 2021
Rotavirus A (RVA) is an important pathogen causing gastroenteritis in many species, including humans and pigs. The objective of this study was to determine the prevalence of RVA in pigs from smallholdings and commercial farms in southern Mozambique and characterize the complete genomes of selected strain...

A narrative review on Rotavirus A in Mozambique

Introduction: Rotavirus A (RVA) is a leading cause of acute infant gastroenteritis in Mozambique, responsible for approximately 13,000 annual infant deaths in peri-urban and other areas. Aim: the present review aimed summarize the most relevant and recent literature regarding RVA infection in Mozambique....

Rotavirus disease burden pre-vaccine introduction in young children in Rural Southern Mozambique, an area of high HIV prevalence

PLoS One; 16 (4), 2021
Rotavirus vaccines have been adopted in African countries since 2009, including Mozambique (2015). Disease burden data are needed to evaluate the impact of rotavirus vaccine. We report the burden of rotavirus-associated diarrhea in Mozambique from the Global Enteric Multicenter Study (GEMS) before vaccin...

Rotavirus A infection in children under five years old with a double health problem: undernutrition and diarrhoea – a cross sectional study in four provinces of Mozambique

BMC infect. dis; 21 (18), 2021
Background: Mozambique has a high burden of group A rotavirus (RVA) infection and chronic undernutrition. This study aimed to determine the frequency and potential risk factors for RVA infection in undernourished children under 5 years old with diarrhoea in Mozambique. Methods: The analysis was conducted...

Molecular epidemiology of rotavirus a strains pre- and post-vaccine (rotarix®) introduction in mozambique, 2012–2019: emergence of genotypes g3p[4] and g3p[8]

PloS pathog; 9 (), 2020
Group A rotavirus (RVA) remains the most important etiological agent associated with severe acute diarrhea in children. Rotarix® monovalent vaccine was introduced into Mozambique’s Expanded Program on Immunization in September 2015. In the present study, we report the diversity and prevalence of rotav...