Background: Infectious diseases are frequent and sometimes deadly in sickle cell disease (SCD) patients. Some of these infectious diseases could be avoided through immunisation, but an immunisation schedule for children with SCD is not available in Gabon.Aim: This study looked into the determinants of im...
La prise en charge de la polyarthrite rhumatoïde (PR) chez les sujets drépanocytaires reste un défi dans les pays de l’Afrique subsaharienne. Une patiente âgée de 33 ans drépanocytaire était atteinte de polyarthrite rhumatoïde immunopositive, déformante. Le diagnostic était posé devant une p...
Introduction.La drépanocytose, une maladie génétique caractérisée par une altération de l’hémoglobine et une déformation des globules rouges, entraîne une hémolyse chronique et une anémie, principale cause de mortalité chez les patients. L’érythropoïétine (EPO) susciteun inté...
Introduction: la crise vaso-occlusive (CVO) est la plus fréquente manifestation de la drépanocytose et la première cause d´hospitalisation des enfants atteints. L´objectif de cette étude est de décrire les aspects cliniques des CVO sévères, de déterminer les étiologies des syndromes infectieux...
Ashande, Colette Masengo;
Ngbolua, Koto-Te-Nyiwa Jean-Paul;
Dibere, Steve Kodondi;
Basosila, Narcisse B;
Ikanga, Eliane K;
Mbembe, Delly B;
Kilembe, Jason T;
Tshilanda, Dorothée D;
Tshibangu, Damien S T;
Mpiana, Pius T.
Sickle cell disease or SS anaemia is the most common haemoglobinopathy in the world and is a major public health problem in endemic regions. The aim of the present study was to conduct a survey in a specialised centre in order to evaluate the cost of care, to identify the infectious diseases associated w...
Anemia, Sickle Cell,
Delivery of Health Care,
Costs and Cost Analysis,
Bacteria,
Antimalarials,
Anti-Bacterial Agents,
Pharmaceutical Preparations,
Medicine, Traditional,
Plant Extracts,
Drug Interactions,
Risk Factors
Plants, especially medicinal varieties, play a vital role in human health. This study aims to analyze the phytochemical properties and evaluate the antisickling activity of Vigna radiata, cultivated in the Democratic Republic of Congo. Results indicate the presence of various chemical compounds, includin...
Dyslipidaemia has been implicated in the pathophysiology of sickle cell disease (SCD) complications; hence its role requires further elucidation.
Objectives: To investigate the relationship between disease severity and plasma lipid levels of patients with sickle cell anaemia.
Methods: A cross-sectional...
Introduction: Sickle cell disease is the most common hereditary hemoglobin disorder in the world, particularly in sub-Saharan Africa. The aim of this study was to describe the clinical presentation and management challenges of sickle cell disease in the towns of Beni and Butembo, in North Kivu province. ...
Anemia, Sickle Cell,
Hemoglobins,
Jaundice,
Blood Transfusion,
Disease Progression,
Genetic Diseases, Inborn,
Rapid Diagnostic Tests,
Nutritional Status,
Malnutrition,
Therapeutics
Background: Sickle cell disease (SCD) is associated with chronic haemolysis, immuno-suppression and susceptibility to infections, which may trigger infection-associated haemolysis (IAH). SCD patients are vulnerable to
anaemic effect of IAH due to vicious interaction between pre-existing ‘inherited’ c...
Folic acid supplementation is an integral aspect of the management of children with sickle cell anaemia (SCA) especially in Africa. In spite of this, there have been concerns about lower folate levels, especially during crisis. AimTo determine red cell folate levels of children with sickle cell anaemia i...
