Introduction: la crise vaso-occlusive (CVO) est la plus fréquente manifestation de la drépanocytose et la première cause d´hospitalisation des enfants atteints. L´objectif de cette étude est de décrire les aspects cliniques des CVO sévères, de déterminer les étiologies des syndromes infectieux...
Ashande, Colette Masengo;
Ngbolua, Koto-Te-Nyiwa Jean-Paul;
Dibere, Steve Kodondi;
Basosila, Narcisse B;
Ikanga, Eliane K;
Mbembe, Delly B;
Kilembe, Jason T;
Tshilanda, Dorothée D;
Tshibangu, Damien S T;
Mpiana, Pius T.
Sickle cell disease or SS anaemia is the most common haemoglobinopathy in the world and is a major public health problem in endemic regions. The aim of the present study was to conduct a survey in a specialised centre in order to evaluate the cost of care, to identify the infectious diseases associated w...
Anemia, Sickle Cell,
Delivery of Health Care,
Costs and Cost Analysis,
Bacteria,
Antimalarials,
Anti-Bacterial Agents,
Pharmaceutical Preparations,
Medicine, Traditional,
Plant Extracts,
Drug Interactions,
Risk Factors
Plants, especially medicinal varieties, play a vital role in human health. This study aims to analyze the phytochemical properties and evaluate the antisickling activity of Vigna radiata, cultivated in the Democratic Republic of Congo. Results indicate the presence of various chemical compounds, includin...
Dyslipidaemia has been implicated in the pathophysiology of sickle cell disease (SCD) complications; hence its role requires further elucidation.
Objectives: To investigate the relationship between disease severity and plasma lipid levels of patients with sickle cell anaemia.
Methods: A cross-sectional...
Introduction: Sickle cell disease is the most common hereditary hemoglobin disorder in the world, particularly in sub-Saharan Africa. The aim of this study was to describe the clinical presentation and management challenges of sickle cell disease in the towns of Beni and Butembo, in North Kivu province. ...
Anemia, Sickle Cell,
Hemoglobins,
Jaundice,
Blood Transfusion,
Disease Progression,
Genetic Diseases, Inborn,
Rapid Diagnostic Tests,
Nutritional Status,
Malnutrition,
Therapeutics
Background: Sickle cell disease (SCD) is associated with chronic haemolysis, immuno-suppression and susceptibility to infections, which may trigger infection-associated haemolysis (IAH). SCD patients are vulnerable to
anaemic effect of IAH due to vicious interaction between pre-existing ‘inherited’ c...
Folic acid supplementation is an integral aspect of the management of children with sickle cell anaemia (SCA) especially in Africa. In spite of this, there have been concerns about lower folate levels, especially during crisis. AimTo determine red cell folate levels of children with sickle cell anaemia i...
Introduction : la drépanocytose est une affection génétique héréditaire responsable d’une déformation des hématies en «faucilles». Elle peut engendrer de nombreuses complications parmi lesquelles la séquestration splénique et l’hypersplénisme. La splénectomie fait partie de l’arsenal t...
Introduction: La mise en place depuis Septembre 2016 au Centre Hospitalier Universitaire (CHUL) d’une consultation d’hématologie dédiée aux adultes drépanocytaires a été l’occasion de mener cette étude dont le but principal était d’établir les profils clinique et paraclinique de l’adul...
BACKGROUND: Sickle cell disease is the commonest geneticdisorder in Nigeria, affecting 2–3% of an estimated population of 160million people. The role of genetic mutations in folate cycle genes,and the variable phenotypic expressions constituting disease severity,needs to be critically examined.O...
