ABSTRACT Purpose: To describe an innovative animal model of eye transplantation used in rabbits. Methods: six Dutch-belted male rabbits were submitted to lateral orbitotomy in the right eye, wide retrobulbar anatomy exposure, dissection of the structures, identification and distal section of the optic ...
Conejos,
Modelos Animales,
Ojo/trasplante,
Nervio Óptico/cirugía,
Electrorretinografía,
Retina/fisiología,
Enucleación del Ojo,
Células Ganglionares de la Retina/fisiología,
Anastomosis Quirúrgica,
Microscopía con Lámpara de Hendidura,
Órbita/cirugía
ABSTRACT Syphilis is a sexually transmitted infection caused by the spirochete Treponema pallidum. Ocular involvement can occur at any time, and it may affect 10% of patients in the secondary stage, and from 2% to 5% in the tertiary stage. Uveitis is the most common presentation of ocular syphilis, affec...
Retinitis Pigmentosa/etiología,
Retinitis Pigmentosa/diagnóstico,
Sífilis/complicaciones,
Sífilis/diagnóstico,
Angiografía con Fluoresceína,
Tomografía de Coherencia Óptica,
Electrorretinografía,
Enfermedades de la Retina/etiología,
Enfermedades de la Retina/diagnóstico,
Fondo de Ojo,
Ceguera/etiología,
Uveítis Posterior/etiología,
Uveítis Posterior/diagnóstico,
Serodiagnóstico de la Sífilis/métodos,
Sífilis/tratamiento farmacológico,
Ceftriaxona/uso terapéutico,
Agudeza Visual
Resumo Apresentamos um caso de distrofia macular oculta bilateral, em paciente de 70 anos com queixa de baixa acuidade visual progressiva, sem achados fundoscópicos ou angiográficos justificáveis. Foram realizados exames de imagem do sistema nervoso central que afastaram lesões expansivas e testes el...
ABSTRACT Purpose: As a class of psychostimulant drugs, amphetamines are widely abused for their stimulant, euphoric, and hallucinogenic properties. Many of these effects result from acute increases in dopamine and serotonin neurotransmission. Following the onset of these effects, 3,4 methylenedioxymetha...
Apoptosis/efectos de los fármacos,
Western Blotting,
Electrorretinografía,
Lesiones Oculares/tratamiento farmacológico,
Lesiones Oculares/genética,
Ratones Endogámicos C57BL,
N-Metil-3,4-metilenodioxianfetamina/toxicidad,
Estrés Oxidativo/efectos de los fármacos,
Degeneración Retiniana/tratamiento farmacológico,
Degeneración Retiniana/genética
ABSTRACT Alström syndrome is a rare disorder characterized by mutations to the ALMS1 gene and clinical findings of childhood obesity, diabetes mellitus, dilated cardiomyopathy, sensorineural hearing loss, and progressive cone-rod dystrophy, which may result in blindness. Ocular manifestations occur in t...
ABSTRACT Purpose: We aimed to evaluate the safety of single intravitreal injection of each of two concentrations of 0.1 ml of sunitinib (1 and 10 mg/ml), 0.1 ml of a drug-free dispersion containing solid lipid nanoparticles, and 0.1 ml of a drug-free dispersion containing polymeric nanocapsules for anal...
RESUMO Incontinência pigmentar, também conhecida como síndrome de Bloch-Sulzberger, é uma doença rara de herança dominante ligada ao X cujas manifestações clínicas incluem lesões dermatológicas típicas combinadas com acometimento neurológico, oftalmológico e dentário. Alterações oculares...
Informes de Casos,
Incontinencia Pigmentaria/complicaciones,
Incontinencia Pigmentaria/genética,
Glaucoma/etiología,
Glaucoma/diagnóstico,
Glaucoma/terapia,
Presión Intraocular,
Epitelio Pigmentado de la Retina/patología,
Agudeza Visual,
Trabeculectomía,
Mitomicina/administración & dosificación,
Acetazolamida/administración & dosificación,
Bimatoprost/administración & dosificación,
Soluciones Oftálmicas,
Administración Oral,
Electrorretinografía,
Gonioscopía,
Atrofia
Abstract The objective of the following work is to document the phenotypic expression variability in Best Disease in first-degree relatives. The information was collected by assessing medical notes, interviewing the patient and obtaining photographic record of the diagnostic methods to which the patient ...
Registros Médicos,
Entrevista,
Fotografía,
Distrofia Macular Viteliforme/genética,
Distrofia Macular Viteliforme/diagnóstico,
Fenotipo,
Electrooculografía,
Electrorretinografía,
Mutación/genética,
Electrofisiología,
Angiografía con Fluoresceína,
Tomografía de Coherencia Óptica,
Bestrofinas,
Canales de Cloruro,
Genes Recesivos
Damico, Francisco Max;
Gasparin, Fábio;
Ioshimoto, Gabriela Lourençon;
Igami, Thais Zamudio;
Cunha,Junior, Armando da Silva;
Fialho, Silva Ligorio;
Liber, Andre Maricio;
Young, Lucy Hwa-yue;
Ventura, Dora Fix.
ABSTRACT Objective : to determine the functional and morphological effects at rabbits retina of PS80 concentration used in the preparation of intravitreal drugs. Methods: eleven New Zealand rabbits received a intravitreal injection of 0.1ml of PS80. As control, the contralateral eye of each rabbit rece...
ABSTRACT This report presents multimodal imaging of a 27-year-old woman diagnosed with benign familial fleck retina (OMIM 228980), an uncommon disorder. Fundus photographs revealed retinal flecks that affected her post-equatorial retina but spared the macular area. Fundus autofluorescence and infrared im...
