Systematic review of insulin-like growth factor 1 gene expression in women with breast cancer
Rev. Assoc. Med. Bras. (1992, Impr.); 67 (9), 2021
Results: 29
Expresión tumoral de BRCA1 y resultados clínicos en pacientes uruguayas diagnosticadas de cáncer de mama antes de los 40 años
Rev. méd. Urug; 36 (1), 2020
Resumen: Las mutaciones de BRCA1 son raras en el cáncer de mama (CM) esporádico; sin embargo, su expresión a nivel tumoral se encuentra disminuida o ausente en 30%-50% de los casos. Objetivo: valorar la expresión tumoral de BRCA1 por inmunohistoquímica (IHQ) en mujeres uruguayas diagnosticadas de ...
Linc-OIP5 in the breast cancer cells regulates angiogenesis of human umbilical vein endothelial cells through YAP1/Notch/NRP1 signaling circuit at a tumor microenvironment
Biol. Res; 53 (), 2020
BACKGROUND: LincRNAs have been revealed to be tightly associated with various tumorigeneses and cancer development, but the roles of specific lincRNA on tumor-related angiogenesis was hardly studied. Here, we aimed to investigate whether linc-OIP5 in breast cancer cells affects the angiogenesis of HUVECs...
Proteínas Adaptadoras Transductoras de Señales/metabolismo, Neoplasias de la Mama/patología, Células Endoteliales de la Vena Umbilical Humana/citología, Neuropilina-1/metabolismo, Receptores Notch/metabolismo, Factores de Transcripción/metabolismo, Microambiente Tumoral, Neoplasias de la Mama/metabolismo, Western Blotting, Línea Celular Tumoral, Inmunohistoquímica, Reacción en Cadena en Tiempo Real de la Polimerasa, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Transducción de Señal
miR-185-5p response to usnic acid suppresses proliferation and regulating apoptosis in breast cancer cell by targeting Bcl2
Biol. Res; 53 (), 2020
BACKGROUND: Breast cancer is the most common cancer types among women. Recent researches have focused on determining the efficiency of alternative molecules and miRNAs in breast cancer treatment. The AIMof this study was to determine the effect of usnic acid response-miR-185-5p on proliferation in the br...
Proteínas Proto-Oncogénicas c-bcl-2/genética, MicroARNs/genética, Neoplasias de la Mama/genética, Benzofuranos/metabolismo, Apoptosis, Neoplasias de la Mama/metabolismo, Línea Celular Tumoral, Proliferación Celular, Regulación hacia Abajo, Regulación Neoplásica de la Expresión Génica, MicroARNs/metabolismo, Proteínas Proto-Oncogénicas c-bcl-2, Reacción en Cadena de la Polimerasa de Transcriptasa Inversa, Transducción de Señal, Transfección
Enhanced production of glutaminase-free L-asparaginase by marine Bacillus velezensis and cytotoxic activity against breast cancer cell lines
Electron. j. biotechnol; 42 (), 2019
Background: The increasing rate of breast cancer globally requires extraordinary efforts to discover new effective sources of chemotherapy with fewer side effects. Glutaminase-free L-asparaginase is a vital chemotherapeutic agent for various tumor malignancies. Microorganisms from extreme sources, such a...
Bacillus/enzimología, Glutaminasa/metabolismo, Asparaginasa/metabolismo, Neoplasias de la Mama/metabolismo, Neoplasias de la Mama/tratamiento farmacológico, Células Inmovilizadas, Fermentación, Células MCF-7, Asparaginasa/biosíntesis, Pruebas de Enzimas, Cinética, Concentración de Iones de Hidrógeno, Temperatura
Triiodothyronine (T3) upregulates the expression of proto-oncogene TGFA independent of MAPK/ERK pathway activation in the human breast adenocarcinoma cell line, MCF7
Arch. endocrinol. metab. (Online); 63 (2), 2019
ABSTRACT Objective: To verify the physiological action of triiodothyronine T3 on the expression of transforming growth factor α (TGFA) mRNA in MCF7 cells by inhibition of RNA Polymerase II and the MAPK/ERK pathway Materials and methods: The cell line was treated with T3 at a physiological dose (10...
Adenocarcinoma/genética, Adenocarcinoma/metabolismo, Neoplasias de la Mama/genética, Neoplasias de la Mama/metabolismo, Línea Celular Tumoral/metabolismo, Regulación Neoplásica de la Expresión Génica/genética, Sistema de Señalización de MAP Quinasas/genética, Células MCF-7/metabolismo, Proto-Oncogenes/genética, ARN Mensajero/genética, Factor de Crecimiento Transformador alfa/efectos de los fármacos, Factor de Crecimiento Transformador alfa/genética, Factor de Crecimiento Transformador alfa/metabolismo, Triyodotironina/genética, Triyodotironina/metabolismo, Triyodotironina/farmacología
WT1 expression as a potential biomarker of malignancy in canine breast tumor
Int. j. morphol; 37 (1), 2019
SUMMARY: Veterinary oncology is very important nowadays to get a better understanding of human carcinogenesis. Estrogen receptor, progesterone receptor and Human Epidermal Growth Factor receptor 2 are frequently evaluated by immunohistochemistry (HIC) in human breast tumor. WT1 is an oncogene, its overex...
Upregulation of miR-129-5p increases the sensitivity to Taxol through inhibiting HMGB1-mediated cell autophagy in breast cancer MCF-7 cells
Braz. j. med. biol. res; 52 (11), 2019
Although Taxol has improved the survival of cancer patients as a first-line chemotherapeutic agent, an increasing number of patients develop resistance to Taxol after prolonged treatment. The potential mechanisms of cancer cell resistance to Taxol are not completely clear. It has been reported that micro...
Antineoplásicos Fitogénicos/metabolismo, Antineoplásicos Fitogénicos/uso terapéutico, Apoptosis/genética, Autofagia/genética, Neoplasias de la Mama/tratamiento farmacológico, Neoplasias de la Mama/genética, Neoplasias de la Mama/metabolismo, Resistencia a Antineoplásicos/genética, Regulación Neoplásica de la Expresión Génica/genética, Proteína HMGB1/genética, Proteína HMGB1/metabolismo, Células MCF-7/metabolismo, MicroARNs/genética, MicroARNs/metabolismo, Paclitaxel/metabolismo, Paclitaxel/uso terapéutico, Regulación hacia Arriba/genética
Effects of glutamine deprivation on oxidative stress and cell survival in breast cell lines
Biol. Res; 52 (), 2019
BACKGROUND: Tumourigenic cells modify metabolic pathways In order to facilitate increased proliferation and cell survival resulting in glucose-and glutamine addiction. Previous research indicated that glutamine deprivation resulted in potential differential activity targeting tumourigenic cells more prom...
Identification of a subtype of poorly differentiated invasive ductal carcinoma of the breast based on vimentin and e-cadherin expression
Rev. bras. ginecol. obstet; 40 (12), 2018
Abstract Objective The use of molecular markers can identify a subgroup of tumors with distinct recurrence patterns. The present study aimed to characterize the immunohistochemical expression of vimentin (VIM), of E-cadherin (CDH1), and of cytokeratin 5 (CK5) in patients with invasive ductal carcinomas...
Neoplasias de la Mama/química, Neoplasias de la Mama/clasificación, Neoplasias de la Mama/metabolismo, Neoplasias de la Mama/patología, Cadherinas/análisis, Cadherinas/biosíntesis, Carcinoma Ductal de Mama/química, Carcinoma Ductal de Mama/clasificación, Carcinoma Ductal de Mama/metabolismo, Carcinoma Ductal de Mama/patología, Inmunohistoquímica, Queratina-5/análisis, Queratina-5/biosíntesis, Persona de Mediana Edad, Vimentina/análisis, Vimentina/biosíntesis