BACKGROUND Streptococcus agalactiae capsular type III strains are a leading cause of invasive neonatal infections. Many pathogens have developed mechanisms to escape from host defense response using the host membrane microdomain machinery. Lipid rafts play an important role in a variety of cellular funct...
To assess the effect of nesiritide on the endothelial function of iliac arteries following endothelia trauma. Right iliac artery trauma was created with a balloon catheter. Ten rabbits were treated with a 4-week subcutaneous injection of nesiritide at a fixed daily dose of 0.1mg/kg. Ten rabbits received ...
RESUMO Objetivo A morte cerebral (MC) desencadeia alterações hemodinâmicas e inflamatórias importantes, comprometendo a viabilidade dos órgãos empregados em transplantes. Para compreender melhor as alterações microcirculatórias nos pulmões de doadores com MC, o presente estudo investigou a mic...
Resumen Introducción: Los síntomas vasomotores y la disfunción endotelial probablemente resulten del déficit estrogénico postmenopausia; no obstante, la relación de ambos con la progresión de la aterosclerosis es un tema controversial. Objetivo: Identificar en mujeres de edad mediana con disfu...
Há uma estreita relação entre os níveis circulantes de adiponectina, resistência à
insulina e risco cardiovascular. As evidências disponíveis que avaliaram a relação entre
adiponectina e exercício físico apresentam algumas controvérsias. Estudos recentes
mostraram que o treinamento aerób...
SUMMARY Atherosclerosis is the leading cause of mortality in the contemporary world. The critical role of the endothelial cells (EC) in vascular homeostasis, the metabolic changes that take place when the cell is activated, and the elements involved in these processes have been widely explored over the p...
Dengue é uma doença causada pelo vírus dengue (DENV) com amplo espectro clínico, variando desde uma infecção assintomática a casos graves, com manifestações hemorrágicas e/ou extravasamento plasmático, que podem levar o paciente ao óbito. Durante a infecção, mediadores pró-inflamatórios, ...
ABSTRACT Objective: To characterize the calcium influx pathways implicated in the sustained elevation of endothelial intracellular calcium concentration, required for the synthesis and release of relaxing factors. Methods: We evaluated the effect of the newly synthesized pyrazole derivatives, described...
Acetilcolina/farmacología,
Aorta Torácica/efectos de los fármacos,
Calcio/farmacología,
Canales de Calcio Activados por la Liberación de Calcio/metabolismo,
Células Endoteliales/efectos de los fármacos,
Células Endoteliales/metabolismo,
Factores Relajantes Endotelio-Dependientes/metabolismo,
Óxido Nítrico/metabolismo,
Ratas Wistar,
Canales Catiónicos TRPC/metabolismo,
Canales Catiónicos TRPV/efectos de los fármacos,
Canales Catiónicos TRPV/metabolismo,
Tapsigargina/farmacología,
Factores de Tiempo,
Vasodilatadores/farmacología
Protein malnutrition (PM) causes anemia and leukopenia by reduction of hematopoietic precursors and impaired production of mediators that induce hematopoiesis, as well as structural and ultrastructural changes in the bone marrow (BM) extracellular matrix. Hematopoiesis occurs in the bone marrow (BM) in d...
Abstract Purpose: To investigate whether hirudin exerts its antithrombin action to decrease the ratio of Human Microvascular Endothelial Cells (HMVECs) apoptosis. Methods: Human microvascular endothelial cells (HMVECs) cultured in the third and fifth generations were used. HMVECs were divided into nor...
