Guimarães, Arthur Emil dos Santos;
Sharma, Abhinav;
Furlaneto, Ismari Perini;
Rutaihwa, Liliana;
Cardoso, Jedson Ferreira;
da Conceição, Marília Lima;
Spinassé, Lizânia Borges;
Machado, Edson;
Lopes, Maria Luiza;
Duarte, Rafael Silva;
Gagneux, Sebastien;
Suffys, Philip Noel;
Lima, Karla Valéria Batista;
Conceição, Emilyn Costa.
BACKGROUND The evaluation of procedures for drug susceptibility prediction of Mycobacterium tuberculosis based on genomic data against the conventional reference method test based on culture is realistic considering the scenario of growing number of tools proposals based on whole-genome sequences (WGS)....
Antituberculosos/farmacología,
Antituberculosos/uso terapéutico,
Brasil,
Farmacorresistencia Bacteriana Múltiple/efectos de los fármacos,
Farmacorresistencia Bacteriana Múltiple/genética,
Pruebas de Sensibilidad Microbiana,
Mycobacterium tuberculosis/efectos de los fármacos,
Mycobacterium tuberculosis/genética,
Mycobacterium tuberculosis/aislamiento & purificación,
Preparaciones Farmacéuticas,
Tuberculosis Resistente a Múltiples Medicamentos/tratamiento farmacológico,
Tuberculosis Resistente a Múltiples Medicamentos/genética,
Secuenciación Completa del Genoma
Abstract INTRODUCTION: This study investigated the genetic environment of bla KPC-2 in Klebsiella pnemoniae multi-drug resistant clinical isolates. METHODS: Four carbapenemase gene isolates resistant to carbapenems, collected from infected patients from two hospitals in Brazil, were investigated using...
Antibacterianos/farmacología,
ADN Bacteriano/genética,
Farmacorresistencia Bacteriana Múltiple,
Infecciones por Klebsiella/microbiología,
Klebsiella pneumoniae/enzimología,
Klebsiella pneumoniae/genética,
Klebsiella pneumoniae/aislamiento & purificación,
Pruebas de Sensibilidad Microbiana,
Plásmidos/genética,
Reacción en Cadena de la Polimerasa,
beta-Lactamasas/genética
Abstract INTRODUCTION: The increase in the prevalence of multidrug-resistant Acinetobacter baumannii infections in hospital settings has rapidly emerged worldwide as a serious health problem. METHODS: This review synthetizes the epidemiology of multidrug-resistant A. baumannii, highlighting resistance ...
Abstract INTRODUCTION: Carbapenem-resistant Klebsiella pneumoniae infection lacks treatment options and is associated with prolonged hospital stays and high mortality rates. The production of carbapenemases is one of the most important factors responsible for this multi-resistance phenomenon. METHODS: ...
Antibacterianos/farmacología,
Proteínas Bacterianas/genética,
Brasil,
ADN Bacteriano,
Farmacorresistencia Bacteriana Múltiple/genética,
Infecciones por Klebsiella/microbiología,
Klebsiella pneumoniae/efectos de los fármacos,
Klebsiella pneumoniae/genética,
Klebsiella pneumoniae/aislamiento & purificación,
Pruebas de Sensibilidad Microbiana,
Reacción en Cadena de la Polimerasa,
Prevalencia,
beta-Lactamasas/genética
The human-adapted strains of the Mycobacterium tuberculosis complex (MTBC) comprise seven phylogenetic lineages originally associated with their geographical distribution. Here, we report the genomes of three drug-resistant clinical isolates of the Latin American-Mediterranean (LAM) family collected in K...
BACKGROUND Tuberculosis (TB) is an infectious disease caused by the bacterium Mycobacterium tuberculosis, and the number of new cases of multidrug resistant TB (MDR-TB), pre extensively drug-resistant TB (pre-XDR-TB) and extensively drug-resistant TB (XDR-TB) has increased considerably worldwide. OBJEC...
Antituberculosos/farmacología,
Brasil,
Farmacorresistencia Bacteriana Múltiple/genética,
Tuberculosis Extensivamente Resistente a Drogas/microbiología,
Pruebas de Sensibilidad Microbiana,
Persona de Mediana Edad,
Mutación/genética,
Mycobacterium tuberculosis/efectos de los fármacos,
Mycobacterium tuberculosis/genética,
Mycobacterium tuberculosis/aislamiento & purificación,
Factores Socioeconómicos,
Tuberculosis Resistente a Múltiples Medicamentos/microbiología
Abstract INTRODUCTION: Acinetobacter baumannii are opportunistic bacteria, highly capable of acquiring antimicrobial resistance through the production of carbapenemases and aminoglycoside modifying enzymes (AMEs). METHODS: Carbapenemase and AME genes were investigated in A. baumannii recovered from inp...
Infecciones por Acinetobacter/microbiología,
Acinetobacter baumannii/efectos de los fármacos,
Acinetobacter baumannii/enzimología,
Acinetobacter baumannii/aislamiento & purificación,
Aminoglicósidos/genética,
Antibacterianos/farmacología,
Proteínas Bacterianas/genética,
Brasil,
Farmacorresistencia Bacteriana Múltiple,
Unidades de Cuidados Intensivos,
Pruebas de Sensibilidad Microbiana,
Centros de Atención Terciaria,
beta-Lactamasas/genética
Abstract INTRODUCTION: Pseudomonas aeruginosa is one of the main pathogens causing infection in intensive care units (ICUs) and usually presents antimicrobial resistance. METHODS: Data were obtained from ICUs between 2010 and 2013. RESULTS: P. aeruginosa had a prevalence of 14.5% of which 48.7% were m...
ABSTRACT Introduction: The presence of Acinetobacter baumannii outside hospitals remains unclear. This study aimed to determine the prevalence of multidrug-resistance (MDR) A. baumannii in the extra-hospital environment in Mthatha, South Africa and to investigate the frequency of carbapenemase-encoding ...
Infecciones por Acinetobacter/tratamiento farmacológico,
Infecciones por Acinetobacter/epidemiología,
Infecciones por Acinetobacter/microbiología,
Infecciones por Acinetobacter/transmisión,
Acinetobacter baumannii/genética,
Acinetobacter baumannii/aislamiento & purificación,
Antibacterianos/uso terapéutico,
Estudios Transversales,
Farmacorresistencia Bacteriana Múltiple/genética,
Pruebas de Sensibilidad Microbiana,
Reacción en Cadena de la Polimerasa,
Prevalencia,
Estudios Prospectivos,
Sudáfrica/epidemiología
Justificativa e objetivos: Infecções Relacionadas à Assistência à Saúde (IRAS) causadas por bacilos Gram negativos multirresistentes (BGN-MDR) são consideradas um problema de saúde pública e um impacto nas taxas de mortalidade nas Unidades de Terapia Intensiva (UTI). O objetivo deste estudo foi ...
Colistina/farmacología,
Tigeciclina/farmacología,
Acinetobacter baumannii/efectos de los fármacos,
Klebsiella pneumoniae/efectos de los fármacos,
Antibacterianos/farmacología,
Farmacorresistencia Bacteriana Múltiple,
Bacterias Gramnegativas/efectos de los fármacos,
Colistina/uso terapéutico,
Tigeciclina/uso terapéutico,
Antibacterianos/uso terapéutico,
Infecciones por Bacterias Gramnegativas/tratamiento farmacológico,
Infección Hospitalaria/tratamiento farmacológico,
Bacterias Gramnegativas/genética,
Fenotipo,
Hospitalización,
Acinetobacter baumannii/genética,
Klebsiella pneumoniae/genética,
Stenotrophomonas maltophilia/efectos de los fármacos,
Stenotrophomonas maltophilia/genética
